Results 131 to 140 of about 35,655 (260)

Structure and function of the calcium-selective TRP channel TRPV6. [PDF]

J Physiol, 2021
Yelshanskaya MV, Nadezhdin KD, Kurnikova MG, Sobolevsky AI.   +3 more
europepmc   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Optical Assessment of Nociceptive TRP Channel Function at the Peripheral Nerve Terminal. [PDF]

Int J Mol Sci, 2021
Aleixandre-Carrera F, Engelmayer N, Ares-Suárez D, Acosta MDC, Belmonte C, Gallar J, Meseguer V, Binshtok AM.   +7 more
europepmc   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

A distinct gene expression mechanism for d‐amino acid utilization in hyperthermophilic archaeon Pyrococcus horikoshii

The FEBS Journal, EarlyView.
The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami, Tomoki Kawase, Taira Uehara, Haruhiko Sakuraba, Tomohiko Matsuzawa, Junji Hayashi, Toshihisa Ohshima   +6 more
wiley   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

TRP Channel Agonists Activate Different Afferent Neuromodulatory Mechanisms in Guinea Pig Urinary Bladder. [PDF]

Front Physiol, 2021
Daugherty SL, Beckel JM, Kim KA, Freeman BA, Liu J, Wang S, de Groat WC, Zhang X.   +7 more
europepmc   +1 more source

Defining cellular mechanisms important for painful chemotherapy‐related neuropathy using long‐term primary cultures of nociceptors

The FEBS Journal, EarlyView.
Basic excitability alterations that drive irregular spontaneous activity in primary nociceptors during chemotherapy‐induced peripheral neuropathy. Using an in vitro model of repeated paclitaxel application to dorsal root ganglion neurons that produces progressive axonal degeneration, Lamberti and colleagues show that all three basic excitability ...
Edgar T. Walters
wiley   +1 more source

TRP channel expression patterns define molecular subtypes, prognosis, and therapeutic targets in gastric cancer. [PDF]

Front Immunol
Ding Z, Liu W, Li ZX, Cheng JQ, Deng C, Wang KW, Li LJ.   +6 more
europepmc   +1 more source

Contrasting Food Web Dynamics Across Oceanographic Boundaries in Subarctic Pelagic Ecosystems

Fisheries Oceanography, EarlyView.
ABSTRACT Understanding the structure of pelagic food webs across multiple trophic levels is critical for elucidating species interactions, energy flow, and anthropogenic impacts on production. This study presents a comprehensive analysis of the eastern North Pacific pelagic food webs, focusing on the Gulf of Alaska (GoA) during late winter of 2019.
Genyffer C. Troina, Evgeny A. Pakhomov, Laurie Weitkamp, Brian P. V. Hunt   +3 more
wiley   +1 more source