Results 131 to 140 of about 1,329,018 (250)

Structural diversity of heat-sensing channel TRPV3 with Olmsted syndrome mutations

Nature Communications
Mutations in TRPV3, a temperature-sensitive ion channel critical for skin physiology, cause severe genodermatosis called Olmsted syndrome (OS). Here we integrate single-channel recordings and cryo-EM to characterize five OS mutants.
Jeffrey Khau, Rutambhara Purohit, Kirill D. Nadezhdin, Irina A. Talyzina, Alexander I. Sobolevsky   +4 more
doaj   +1 more source

Role of transient receptor potential (TRP) channels in osteoarthritis: a comprehensive review

Frontiers in Pharmacology
Osteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degeneration of articular cartilage, synovial inflammation, and persistent pain, which severely impairs the quality of life for hundreds of millions of patients ...
Pengyan Qiao, Wei Wang, Sumiao Liu, Yanli Yang, Pingzhi Wang, Yang Liu, Yazhen Su, Peng Hu, Jie Pan, Liyun Zhang   +9 more
doaj   +1 more source

Cold-Temperature Coding with Bursting and Spiking Based on TRP Channel Dynamics in Drosophila Larva Sensory Neurons. [PDF]

Int J Mol Sci, 2023
Maksymchuk N, Sakurai A, Cox DN, Cymbalyuk GS.   +3 more
europepmc   +1 more source

From knowledge to action: the importance of characterizing herbicide resistance mechanisms for implementing management strategies

Pest Management Science, EarlyView.
This review bridges the gap between understanding resistance mechanisms and applying them in weed management, highlighting how mechanistic insights reveal vulnerabilities that can guide more effective control strategies. Abstract Herbicide resistance remains one of the most intensively studied areas in weed science because of its direct consequences ...
Luan Cutti, Eric L. Patterson, Todd A. Gaines, Aldo Merotto   +3 more
wiley   +1 more source

Modification of the TRP Channel TRPA1 as a Relevant Factor in Migraine-Related Intracranial Hypersensitivity. [PDF]

Int J Mol Sci, 2023
Masood T, Lakatos S, Rosta J.
europepmc   +1 more source

Amplitudes of TG neuron depolarizations triggered by administration of odorants and odorants plus the TRP channel antagonists CPZ, BCTC, and AITC.

, 2013
Amplitudes of TG neuron depolarizations triggered by administration of odorants and odorants plus the TRP channel antagonists CPZ, BCTC, and AITC.
Christian Horst Wetzel (474715), Nicole Schöbel (120873), Leopoldo Beltrán (474714), Hanns Hatt (120893), Jessica Kyereme (474713), Matthias Lübbert (120876)   +5 more
core   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Identification of a TRP channel-related risk model for predicting prognosis and therapeutic effects of patients with hepatocellular carcinoma. [PDF]

J Cancer Res Clin Oncol, 2023
Pang C, Xu Z, Han J, Li F, Zhu H, Zhang J, Wang D, Xu X.   +7 more
europepmc   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source

Genome-Wide Characterization and Gene Expression Analysis of TRP Channel Superfamily Genes in the Migratory Locust, Locusta migratoria. [PDF]

Genes (Basel), 2023
Yang Y, Guo W, Wang M, Zhang D.
europepmc   +1 more source