Results 151 to 160 of about 10,134 (175)

TRPC Channel Structure and Properties

2017
TRPC channels are the first identified members in the TRP family. They function as either homo- or heterotetramers regulating intracellular Ca2+ concentration in response to numerous physiological or pathological stimuli. TRPC channels are nonselective cation channels permeable to Ca2+.
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The enigmatic TRPCs: multifunctional cation channels

Trends in Cell Biology, 2004
Abstract Canonical transient receptor potential (TRPC) channels are vertebrate homologs of the Drosophila photoreceptor channel. Considerable research has been carried out on the seven members of this family, particularly regarding their possible role in Ca 2+ entry.
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Physiological Functions and Regulation of TRPC Channels

2014
The TRP-canonical (TRPC) subfamily, which consists of seven members (TRPC1-TRPC7), are Ca(2+)-permeable cation channels that are activated in response to receptor-mediated PIP2 hydrolysis via store-dependent and store-independent mechanisms. These channels are involved in a variety of physiological functions in different cell types and tissues.
Hwei Ling, Ong, Lorena B, de Souza, Kwong Tai, Cheng, Indu S, Ambudkar   +3 more
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TRPC Channels

2023
Jin Bin Tian, Michael X. Zhu
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Inositol lipids and TRPC channel activation

Biochemical Society Symposia, 2007
The original hypothesis put forth by Bob Michell in his seminal 1975 review held that inositol lipid breakdown was involved in the activation of plasma membrane calcium channels or ‘gates’. Subsequently, it was demonstrated that while the interposition of inositol lipid breakdown upstream of calcium signalling was correct, it was predominantly the ...
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TRPC Channels and Programmed Cell Death

2017
Neurotrophins, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), bind to their high-affinity receptors to promote neuronal survival during brain development. One of the key downstream pathways is the phospholipase C (PLC) pathway, which not only plays a central role in calcium release from internal store but also in ...
Jian, Zhou, Yichang, Jia
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TRPC Channel Downstream Signaling Cascades

2017
The family of TRP channel is comprised of a large group of cation-permeable channels, displaying as signaling integrators for sensing extracellular stimulus and initiating intracellular signaling cascades. This chapter offers a brief review of the signaling molecules related to TRPC channels, the first identified mammalian TRP family.
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Neurological and Motor Disorders: TRPC in the Skeletal Muscle

2017
Transient receptor potential canonical (TRPC) channels belong to the large family of TRPs that are mostly nonselective cation channels with a great variety of gating mechanisms. TRPC are composed of seven members that can all be activated downstream of agonist-induced phospholipase C stimulation, but some members are also stretch-activated and/or are ...
Sauc, Sophie, Frieden, Maud
openaire   +3 more sources

TRPC and TRPV Channels’ Role in Vascular Remodeling and Disease

International Journal of Molecular Sciences, 2020
Raquel del Toro Estevez, Tarik Smani, Marta Martin Bórnez   +2 more
exaly  

Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

International Journal of Molecular Sciences, 2020
Kid Tornquist, Muhammad Yasir Asghar
exaly