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TRPC Channels and Mental Disorders
2017Transient receptor potential canonical (TRPC) channels mediate the influx of different types of cations through the cell membrane and are involved in many functions of the organism. Evidences of involvement of TRPC channels in neuronal development suggest that this family of proteins might play a role in certain neurological disorders.
Karina, Griesi-Oliveira +2 more
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TRPC Channels and Programmed Cell Death
2017Neurotrophins, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), bind to their high-affinity receptors to promote neuronal survival during brain development. One of the key downstream pathways is the phospholipase C (PLC) pathway, which not only plays a central role in calcium release from internal store but also in ...
Jian, Zhou, Yichang, Jia
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In vivo TRPC functions in the cardiopulmonary vasculature
Cell Calcium, 2007Cardiovascular diseases are the leading cause of death in the industrialized countries. The cardiovascular system includes the systemic blood circulation, the heart and the pulmonary circulation providing sufficient blood flow and oxygen to peripheral tissues and organs according to their metabolic demand.
Alexander, Dietrich +5 more
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Inositol lipids and TRPC channel activation
Biochemical Society Symposia, 2007The original hypothesis put forth by Bob Michell in his seminal 1975 review held that inositol lipid breakdown was involved in the activation of plasma membrane calcium channels or ‘gates’. Subsequently, it was demonstrated that while the interposition of inositol lipid breakdown upstream of calcium signalling was correct, it was predominantly the ...
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TRPC Channel Structure and Properties
2017TRPC channels are the first identified members in the TRP family. They function as either homo- or heterotetramers regulating intracellular Ca2+ concentration in response to numerous physiological or pathological stimuli. TRPC channels are nonselective cation channels permeable to Ca2+.
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The enigmatic TRPCs: multifunctional cation channels
Trends in Cell Biology, 2004Abstract Canonical transient receptor potential (TRPC) channels are vertebrate homologs of the Drosophila photoreceptor channel. Considerable research has been carried out on the seven members of this family, particularly regarding their possible role in Ca 2+ entry.
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Physiological Functions and Regulation of TRPC Channels
2014The TRP-canonical (TRPC) subfamily, which consists of seven members (TRPC1-TRPC7), are Ca(2+)-permeable cation channels that are activated in response to receptor-mediated PIP2 hydrolysis via store-dependent and store-independent mechanisms. These channels are involved in a variety of physiological functions in different cell types and tissues.
Hwei Ling, Ong +3 more
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TRPC Channel Downstream Signaling Cascades
2017The family of TRP channel is comprised of a large group of cation-permeable channels, displaying as signaling integrators for sensing extracellular stimulus and initiating intracellular signaling cascades. This chapter offers a brief review of the signaling molecules related to TRPC channels, the first identified mammalian TRP family.
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