Results 131 to 140 of about 9,940 (176)

RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC

Cell Calcium, 2008
TRPCs function as cation channels in non-excitable cells. The N-terminal tails of all TRPCs contain an ankyrin-like repeat domain, one of the most common protein-protein interaction motifs. Using a yeast two-hybrid screening approach, we found that RNF24, a new membrane RING-H2 protein, interacted with the ankyrin-like repeat domain of TRPC6.
Marc P, Lussier, Pascale K, Lepage, Simon M, Bousquet, Guylain, Boulay   +3 more
openaire   +2 more sources

The structure of TRPC ion channels

Cell Calcium, 2019
Briefly review the recent structural work of transient receptor potential canonical (TRPC) ion channels by using electron cryo-microscopy (cryo-EM). The high resolution structures of TRPC3, TRPC4, TRPC5 and TRPC6 are discussed.
Jian Li, Xu Zhang, Zongli Li
exaly   +3 more sources

TRPC channels as signal transducers

Pflügers Archiv - European Journal of Physiology, 2005
The study of the TRPC cation channels as signal transducers in sensory neurons is in its infancy. Mechanoreceptors that monitor arterial pressure are prime candidates for the involvement of TRPC channels as either primary mechanical transducers or as modulators of the transduction process. Their activity patterns can be regulated by growth factors such
Patricia A, Glazebrook, William P, Schilling, Diana L, Kunze   +2 more
openaire   +2 more sources

TRPCs as MS Channels

2007
This chapter reviews recent evidence indicating that canonical or classical transient receptor potential (TRPC) channels are directly or indirectly mechanosensitive (MS) and can therefore be designated as mechano-operated channels (MOCs). The MS functions of TRPCs may be mechanistically related to their better known functions as store-operated and ...
Owen P, Hamill, Rosario, Maroto
openaire   +2 more sources

TRPC Channels and Glioma

2017
Glioma is the most common type of brain tumors and malignant glioma is extremely lethal, with patients' 5-year survival rate less than 10%. Treatment of gliomas poses remarkable clinical challenges, not only because of their particular localization but also because glioma cells possess several malignant biological features, including highly ...
Shanshan, Li, Xia, Ding
openaire   +2 more sources

Organization and function of TRPC channelosomes

Pflügers Archiv - European Journal of Physiology, 2007
TRPC proteins constitute a family of conserved Ca2+-permeable cation channels which are activated in response to agonist-stimulated PIP2 hydrolysis. These channels were initially proposed to be components of the store-operated calcium entry channel (SOC).
Indu S, Ambudkar, Hwei Ling, Ong
openaire   +2 more sources

Hyperforin: To Be or Not to Be an Activator of TRPC(6)

2015
Meantime, it is well accepted that hyperforin, the chemical instable phloroglucinol derivative of Hypericum perforatum, St. John's wort, is the pharmacophore of St. John's wort extracts. With the decline of this scientific discussion, another controversial aspect has been arisen, the question regarding the underlying mechanism leading to the ...
Kristina, Friedland, Christian, Harteneck   +1 more
openaire   +2 more sources

Trafficking mechanisms and regulation of TRPC channels

Cell Calcium, 2014
TRPC channels are Ca(2+)-permeable cation channels which are regulated downstream from receptor-coupled PIP2 hydrolysis. These channels contribute to a wide variety of cellular functions. Loss or gain of channel function has been associated with dysfunction and aberrant physiology.
Lorena Brito De Souza, Indu Ambudkar
exaly   +3 more sources

Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models

Biochemical and Biophysical Research Communications, 2004
In order to elucidate the functional role of TRPC genes, in vivo, the targeted inactivation of these genes in mice is an invaluable technique. In this review, we summarize the currently available results on the phenotype of TRPC-deficient mouse lines.
Rudi Vennekens, Marc Freichel
exaly   +3 more sources

TRPC Channels and Stroke

2017
TRPC channels play important roles in neuronal death/survival in ischemic stroke, vasospasm in hemorrhagic stroke, thrombin-induced astrocyte pathological changes, and also in the initiation of stroke by affecting blood pressure and atherogenesis. TRPCs' unique channel characters and downstream pathways make them possible new targets for stroke therapy.
openaire   +2 more sources