Results 151 to 160 of about 1,006,736 (177)
Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion [PDF]
International Journal of Molecular Sciences, 2020 Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating.
Kid Tornquist, Muhammad Yasir Asghar
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Mechanisms of lipid regulation and lipid gating in TRPC channels [PDF]
Cell Calcium, 2016 TRPC proteins form cation channels that integrate and relay cellular signals by mechanisms involving lipid recognition and lipid-dependent gating. The lipohilic/amphiphilic molecules that function as cellular activators or modulators of TRPC proteins ...
Klaus Gröschner, Barbora Svobodova
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TRPC channels as STIM1-regulated store-operated channels
Cell Calcium, 2007 Receptor-activated Ca2+ influx is mediated largely by store-operated channels (SOCs). TRPC channels mediate a significant portion of the receptor-activated Ca2+ influx.
Min Goo Lee, Guo N Huang, Paul Worley
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Determining the functional role of TRPC channels in primary cells
Pflugers Archiv European Journal of Physiology, 2005 Although the TRPC members of the mammalian transient receptor potential TRP cation channel family were the first to be described in 1995, the depth of knowledge of TRPC channels has fallen behind that of their counterparts in the TRPV and TRPM ...
Martin Gosling
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Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes [PDF]
Neuron, 2022 peer reviewedIn the mammalian brain TRPC channels, a family of Ca2+-permeable cation channels, are involved in a variety of processes from neuronal growth and synapse formation to transmitter release, synaptic transmission and plasticity.
Bernd Fakler +2 more
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Archives of Biochemistry and Biophysics, 2022
In whole-cell voltage clamped bovine adrenal chromaffin cells maintained at a holding potential of -70 mV, a single 5 ns, 5 MV/m pulse elicited an inward current carried mainly by Na+ that displayed inward rectification and a reversal potential near -3 mV, a voltage consistent with a non-selective cation current.
Lisha Yang +4 more
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In whole-cell voltage clamped bovine adrenal chromaffin cells maintained at a holding potential of -70 mV, a single 5 ns, 5 MV/m pulse elicited an inward current carried mainly by Na+ that displayed inward rectification and a reversal potential near -3 mV, a voltage consistent with a non-selective cation current.
Lisha Yang +4 more
openaire +2 more sources
European Journal of Pharmacology, 2020
The cardiac plexus, which contains parasympathetic ganglia, plays an important role in regulating cardiac function. Histamine is known to excite intracardiac ganglion neurons, but the underlying mechanism is obscure. In the present study, therefore, the effect of histamine on rat intracardiac ganglion neurons was investigated using perforated patch ...
Aya, Sato +12 more
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The cardiac plexus, which contains parasympathetic ganglia, plays an important role in regulating cardiac function. Histamine is known to excite intracardiac ganglion neurons, but the underlying mechanism is obscure. In the present study, therefore, the effect of histamine on rat intracardiac ganglion neurons was investigated using perforated patch ...
Aya, Sato +12 more
openaire +2 more sources
The enigmatic TRPCs: multifunctional cation channels
Trends in Cell Biology, 2004Abstract Canonical transient receptor potential (TRPC) channels are vertebrate homologs of the Drosophila photoreceptor channel. Considerable research has been carried out on the seven members of this family, particularly regarding their possible role in Ca 2+ entry.
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2002
Mammalian homologues of the Drosophila transient receptor potential (TRP) protein, more specifically TRPC1-7, have been proposed to function as receptor-stimulated Ca2+ entry channels. To date, the properties of TRPC1-7 have been extensively studied in heterologous expression studies.
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Mammalian homologues of the Drosophila transient receptor potential (TRP) protein, more specifically TRPC1-7, have been proposed to function as receptor-stimulated Ca2+ entry channels. To date, the properties of TRPC1-7 have been extensively studied in heterologous expression studies.
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TRPC and SOC Cationic Channels in Vascular Smooth Muscle
Neurophysiology, 2003D. J. Beech +4 more
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