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TRPC Channel Modulators and Their Potential Therapeutic Applications
Pharmaceutical Patent Analyst, 2015The transient receptor potential canonical (TRPC) channels have gained interest as potential therapeutic targets for respiratory diseases, neurological disorders, cardiovascular disorders, pain, cancer and several other pathological conditions. The TRPC receptor family consists of seven isoforms (C1-C7) and has been divided into three subfamilies based
Neelima, Khairatkar-Joshi +4 more
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TRPC Channel Structure and Properties
2017TRPC channels are the first identified members in the TRP family. They function as either homo- or heterotetramers regulating intracellular Ca2+ concentration in response to numerous physiological or pathological stimuli. TRPC channels are nonselective cation channels permeable to Ca2+.
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Inositol lipids and TRPC channel activation
Biochemical Society Symposia, 2007The original hypothesis put forth by Bob Michell in his seminal 1975 review held that inositol lipid breakdown was involved in the activation of plasma membrane calcium channels or ‘gates’. Subsequently, it was demonstrated that while the interposition of inositol lipid breakdown upstream of calcium signalling was correct, it was predominantly the ...
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TRPC Channels in Cardiac Hypertrophy
2013Impaired cardiomyocyte Ca2+ handling is considered as crucial factor programming cardiac hypertrophy and heart failure. It has, however, not been entirely resolved what type of Ca2+ signals is involved in mechanisms inducing hypertrophic remodelling.
Nadine Kirschmer +2 more
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TRPC Channel Downstream Signaling Cascades
2017The family of TRP channel is comprised of a large group of cation-permeable channels, displaying as signaling integrators for sensing extracellular stimulus and initiating intracellular signaling cascades. This chapter offers a brief review of the signaling molecules related to TRPC channels, the first identified mammalian TRP family.
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TRPC Channels: Integrators of Multiple Cellular Signals
2007TRPC channels are ubiquitously expressed among cell types and mediate signals in response to phospholipase C (PLC)-coupled receptors. TRPC channels function as integrators of multiple signals resulting from receptor-induced PLC activation, which catalyzes the breakdown of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce inositol 1,4,5 ...
J, Soboloff +9 more
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Calcium transport and sensing in TRPC channels – New insights into a complex feedback regulation
Cell Calcium, 2023Oleksandra Tiapko, Klaus Gröschner
exaly