Results 71 to 80 of about 3,697 (189)
Direct activation of lysosomal TRPML1 channels by Rap.
, 2019 (A) Whole-endolysosome recording configuration. Pipette (luminal) solution was standard Tyrode’s solution with the pH adjusted to 4.6 to mimic the lysosomal lumen. Bath (internal) solution was a K+-based solution (140 mM K+-gluconate).
Rong Shao (202747) +18 more
core +1 more source
Metal‐dependent regulated cell death: Molecular architecture and translational frontiers
iMeta, Volume 5, Issue 3, June 2026.Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu +20 more
wiley +1 more source
Frontiers in Neurology, 2017 BackgroundTo validate our speculation that curcumin may ameliorate Alzheimer’s disease (AD) pathogenesis by regulating PI(3,5)P2 and transient receptor potential mucolipin-1 (TRPML1) expression levels.MethodsWe developed an animal model presenting AD by ...
Lu Zhang +6 more
doaj +1 more source
Intercompartmental communication in senescence
FEBS Open Bio, Volume 16, Issue 5, Page 837-856, May 2026.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Tem increases autophagic flux through TRPML1.
, 2019 (A) Tem (5 μM, 3 h) induced TFEB (green) nuclear translocation in TRPML1 stable cell lines (TRPML1 HEK Tet-On) upon Dox (1 μg/ml, overnight) induction. GPN (200 μM, 2 h) was used as a positive control due to its consistent activation on TFEB in HEK cells
Rong Shao (202747) +18 more
core +1 more source
The Journal of Physiology, Volume 604, Issue 9, Page 3611-3632, 1 May 2026.Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm +3 more
wiley +1 more source
Inhibition of lysosomal TRPML1 channel eliminates breast cancer stem cells by triggering ferroptosis
Cell Death DiscoveryCancer stem cells (CSCs) are a sub-population of cells possessing high tumorigenic potential, which contribute to therapeutic resistance, metastasis and recurrence.
Chunhong Fan +6 more
doaj +1 more source
Mechanosensing in Dendritic Cells
Immunological Reviews, Volume 337, Issue 1, January 2026.ABSTRACT Since their discovery, dendritic cells have been recognized for their unusual capacity to sense and respond to physical stimuli within their environment. However, it took nearly two decades—and the advent of mechanobiology—to elucidate the underlying mechanisms and functional implications of this mechanical hypersensitivity. In this review, we
Vincent Calmettes +5 more
wiley +1 more source
Advances in Pharmacological and Pharmaceutical Sciences, Volume 2026, Issue 1, 2026.Parkinson’s disease (PD) is a neurodegenerative disorder associated with dopaminergic neuronal loss, mitochondrial dysfunction, and redox imbalance. Huperzine B (HupB), an alkaloid derived from Huperzia species, has demonstrated antioxidant and acetylcholinesterase‐inhibitory activity; however, its effects in toxin‐induced cellular models of ...
Kittikun Viwatpinyo +7 more
wiley +1 more source
Neural Plasticity, Volume 2026, Issue 1, 2026.Synaptic plasticity is a fundamental property of the nervous system that underpins learning, memory, and adaptive behavior across the lifespan. Disruption of plasticity mechanisms is increasingly recognized as a unifying feature of age‐related neurodegenerative and neuropsychiatric disorders.
Shaik Basha +7 more
wiley +1 more source