Results 81 to 90 of about 3,697 (189)

Rap and rapalogs induce TRPML1- and Ca²⁺-dependent TFEB nuclear translocation in TRPML1-overexpressing cells.

, 2019
(A) Rap (5 μM) and Tem (5 μM) induced TFEB nuclear translocation in TFEB-GFP stable cells overexpressing mCherry-TRPML1 (asterisks). TFEB nuclear translocation was not seen with Zota (5 μM). Scale bar = 10 μm.
Rong Shao (202747), Nirakar Sahoo (1923211), Chenlang Gao (6718490), Xiaoli Zhang (135098), Dan Li (106345), Qiong Gao (13880), Ken Inoki (6718493), Tadashi Eguchi (1388379), Wei Chen (23863), Han Zhao (130768), Fumitaka Kudo (1388382), Xueni Yan (6718484), Shiyi Wang (6066389), Haoxing Xu (70454), Benfang Ruan (6718496), Yao Yao (335996), Meimei Yang (6718487), Junsheng Yang (606741), Lin Su (548272)   +18 more
core   +1 more source

The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk [PDF]

, 2023
Cytotoxic lymphocytes eliminate cancer cells through the release of lytic granules, a specialized form of secretory lysosomes. This compartment is part of the pleomorphic endolysosomal system and is distinguished by its highly dynamic Ca2+ signaling ...
Wiiger, MT, Krokeide, SZ, Palacios, D, Brech, A, Clement, D, Szabo, EK, Malmberg, KJ, Grimm, C, Stenmark, H, Chang, YT, Majhi, RK, Patel, S, Vincenti, M   +12 more
core  

Nanoparticles encapsulating phosphatidylinositol derivatives promote neuroprotection and functional improvement in preclinical models of ALS via a long-lasting activation of TRPML1 lysosomal channel

Pharmacological Research
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease currently incurable, in which motor neuron degeneration leads to voluntary skeletal muscle atrophy.
Valentina Tedeschi, Valeria Nele, Valeria Valsecchi, Serenella Anzilotti, Antonio Vinciguerra, Laura Zucaro, Maria Josè Sisalli, Chiara Cassiano, Nunzia De Iesu, Giuseppe Pignataro, Lorella Maria Teresa Canzoniero, Anna Pannaccione, Giuseppe De Rosa, Agnese Secondo   +13 more
doaj   +1 more source

Lysosomal calcium is modulated by STIM1/TRPML1 interaction which participates to neuronal survival during ischemic preconditioning

, 2021
A robust activity of the lysosomal Ca2+ channel TRPML1 is sufficient to correct cellular defects in neurodegeneration. Importantly, lysosomes are refilled by the endoplasmic reticulum (ER). However, it is unclear how TRPML1 function could be modulated by
Petrozziello, Tiziana, Secondo, Agnese, Sisalli, Maria José, Canzoniero, Lorella Maria Teresa, Tedeschi, Valentina   +4 more
core   +1 more source

MDM2 is the E3 ubiquitin ligase of TRPML1.

(A) Mice were either mock-infected or intranasally infected with PRV HN1201 (2 × 103 TCID50 per mouse) and were daily injected with vehicle or P4 (10 mg/kg per mouse) for two days. TRPML1 in the uterus was detected by immunoblotting (n = 3).
Guo-Yu Yang (1728175), Bei-Bei Chu (8617002), Bing-Qian Su (8616981), Jiang Wang (14683), Sheng-Li Ming (8616975)   +4 more
core   +1 more source

Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel

Nature Communications
Lysosomes are best known for their roles in inflammatory responses by engaging in autophagy to remove inflammasomes. Here, we describe an unrecognized role for the lysosome, showing that it finely controls macrophage inflammatory function by manipulating
Yanhong Xing, Meng-meng Wang, Feifei Zhang, Tianli Xin, Xinyan Wang, Rong Chen, Zhongheng Sui, Yawei Dong, Dongxue Xu, Xingyu Qian, Qixia Lu, Qingqing Li, Weijie Cai, Meiqin Hu, Yuqing Wang, Jun-li Cao, Derong Cui, Jiansong Qi, Wuyang Wang   +18 more
doaj   +1 more source

PRV infection upregulates TRPML1 expression.

(A) PK-15 cells were infected with PRV HN1201 (MOI = 0.1) for 0–24 hours. MCOLN1 mRNA levels were detected using qRT-PCR analysis. (B) Mice were mock-infected or intranasally infected with PRV HN1201 (2 × 103 TCID50 per mouse) for two days.
Guo-Yu Yang (1728175), Bei-Bei Chu (8617002), Bing-Qian Su (8616981), Jiang Wang (14683), Sheng-Li Ming (8616975)   +4 more
core   +1 more source

Metabolomic Approach to Identify Potential Biomarkers in KRAS-Mutant Pancreatic Cancer Cells

Biomedicines
Pancreatic cancer is characterized by its high mortality rate and limited treatment options, often driven by oncogenic RAS mutations. In this study, we investigated the metabolomic profiles of pancreatic cancer cells based on their KRAS genetic status ...
Boyun Kim, Jewon Jung
doaj   +1 more source

TRPML1 gating modulation by allosteric mutations and lipids (Design of allosteric mutations that recapitulate the gating of TRPML1)

Abstract Transient Receptor Potential Mucolipin 1 (TRPML1) is a lysosomal cation channel whose loss-of-function mutations directly cause the lysosomal storage disorder mucolipidosis type IV (MLIV). TRPML1 can be allosterically regulated by various ligands including natural lipids and small synthetic molecules and the channel undergoes a
Ninghai Gan, Yan Han, Weizhong Zeng, Youxing Jiang   +3 more
openaire   +1 more source

The Ragulator complex and lysosomal calcium release are crucial for cell migration

Life Science Alliance
Lysosomal calcium efflux via TRPML1 drives leukocyte migration by enhancing Lamtor1–MPRIP interaction, and ouabain improves pathogenic inflammation by disrupting Lamtor1’s lysosomal localization. Immune cells migrate via actomyosin contractility mediated
Tatsunori Jo, Kohei Tsujimoto, Takeshi Nakatani, Daiki Nagira, Yutaka Muto, Takehiro Hirayama, Hachiro Konaka, Masato Okada, Hyota Takamatsu, Atsushi Kumanogoh   +9 more
doaj   +1 more source