Results 91 to 100 of about 3,697 (189)

TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling [PDF]

, 2021
A major goal of studying melanoma is to identify therapeutic vulnerabilities that can be exploited to improve patient treatment. Melanoma cells are particularly sensitive to perturbations in ion homeostasis, especially when ion gradients are perturbed in
Kasitinon, Stacy Yuan
core  

Lysosomal Ca2+ release-facilitated TFEB nuclear translocation alleviates ischemic brain injury by attenuating autophagic/lysosomal dysfunction in neurons

Scientific Reports
Neuronal death was frequently driven by autophagic/lysosomal dysfunction after ischemic stroke, whereas how to restore the impaired autophagic flux remained elusive.
Qian Lei, Xuemei Chen, Yajie Xiong, Shangdan Li, Jiaqian Wang, Hongyun He, Yihao Deng   +6 more
doaj   +1 more source

P4 stimulates the ubiquitination and proteasomal degradation of TRPML1 through MDM2.

(A) PK-15 cells were treated with P4 (10 μM) for 0–24 hours. The mRNA levels of TRPML1 were analyzed by qRT-PCR. (B) PK-15 cells were treated with P4 (0–30 μM) for 24 hours. TRPML1 levels were analyzed by immunoblotting. (C) PK-15 cells were treated with
Guo-Yu Yang (1728175), Bei-Bei Chu (8617002), Bing-Qian Su (8616981), Jiang Wang (14683), Sheng-Li Ming (8616975)   +4 more
core   +1 more source

LOSS OF TRPML1 ALTERS CELLULAR FUNCTIONS OUTSIDE OF THE LYSOSOME: DISSECTING THE RELATIONSHIP BETWEEN LYSOSOMAL AND MITOCHONDRIAL HEALTH IN MLIV [PDF]

, 2015
The transient receptor potential mucolipin 1 (TRPML1) is a lysosomal ion channel permeable to cations, including Fe2+. Mutations in MCOLN1, the gene coding for TRPML1, cause the lysosomal storage disease (LSD) Mucolipidosis type IV (MLIV).
Coblentz, Jessica
core  

TRPML1 inhibitor ML-SI1 suppresses prostate cancer through dual regulation of androgen receptor and polyamine metabolism

Frontiers in Medicine
BackgroundProstate cancer (PCa) is the second leading cause of cancer-related death in men worldwide, with metastasis and drug resistance representing major drivers of mortality.
Jiongzheng Li, Jipeng Ding, Hongfei Wei, Rongrong Ding, Jintong Zhu, Yufei Yan, Yiming Yang, Jia Zhao, Jing Li   +8 more
doaj   +1 more source

P4-induced aberrant lysosomal function is rescued by TRPML1.

(A and B) PK-15 cells were infected with PRV HN1201 (MOI = 0.1) for 0–24 hours. The mRNA levels of TPCN1 (A) and TPCN2 (B) were analyzed by qRT-PCR. (C) PK-15 cells were treated as indicated in (A).
Guo-Yu Yang (1728175), Bei-Bei Chu (8617002), Bing-Qian Su (8616981), Jiang Wang (14683), Sheng-Li Ming (8616975)   +4 more
core   +1 more source

TRPML1 Regulates Intracellular Trafficking and Calcium-Dependent Lysosomal Clearance of Polystyrene Nanoplastics in Renal Tubular Cells

Nanoplastics have emerged as an important environmental and health concern because of their ability to cross biological barriers, accumulate in tissues, and disrupt cellular homeostasis.
Yang seoyoon, Hyeonji Jang, Boyun Kim, Jewon Jung   +3 more
core   +1 more source

Tem activates the endogenous TRPML1-TFEB pathway.

, 2019
(A) Tem (10 μM, 9 h) induced TFEB (green) nuclear translocation in WT but not ML1−/− fibroblasts. TFEB nuclear translocation was inhibited by coapplication of ML-SI3 (10 μM). Nuclei were labelled with DAPI (red, pseudo-color). Scale bar = 10 μm.
Rong Shao (202747), Nirakar Sahoo (1923211), Chenlang Gao (6718490), Xiaoli Zhang (135098), Dan Li (106345), Qiong Gao (13880), Ken Inoki (6718493), Tadashi Eguchi (1388379), Wei Chen (23863), Han Zhao (130768), Fumitaka Kudo (1388382), Xueni Yan (6718484), Shiyi Wang (6066389), Haoxing Xu (70454), Benfang Ruan (6718496), Yao Yao (335996), Meimei Yang (6718487), Junsheng Yang (606741), Lin Su (548272)   +18 more
core   +1 more source

TRPML1 ion channel promotes HepaRG cell differentiation under simulated microgravity conditions

npj Microgravity
Stem cell differentiation must be regulated by intricate and complex interactions between cells and their surrounding environment, ensuring normal organ and tissue morphology such as the liver1.
Huancai Fan, Dongyuan Lü, Zheng Lu, Hangyu Li, Zijuan Qi, Shujin Sun, Dongshi Guan, Mian Long, Ming Gao, Sijin Liu   +9 more
doaj   +1 more source

Coxiella burnetii effector CvpE maintains biogenesis of Coxiella-containing vacuoles by suppressing lysosome tubulation through binding PI(3)P and perturbing PIKfyve activity on lysosomes

Virulence
Coxiella burnetii (C. burnetii) is the causative agent of Q fever, a zoonotic disease. Intracellular replication of C. burnetii requires the maturation of a phagolysosome-like compartment known as the replication permissive Coxiella-containing vacuole ...
Mingliang Zhao, Shan Zhang, Weiqiang Wan, Chunyu Zhou, Nana Li, Ruxi Cheng, Yonghui Yu, Xuan Ouyang, Dongsheng Zhou, Jun Jiao, Xiaolu Xiong   +10 more
doaj   +1 more source