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The dual role of TRPV1 in peripheral neuropathic pain: pain switches caused by its sensitization or desensitization

Frontiers in Molecular Neuroscience
The transient receptor potential vanilloid 1 (TRPV1) channel plays a dual role in peripheral neuropathic pain (NeuP) by acting as a “pain switch” through its sensitization and desensitization.
Ning Gao, Meng Li, Weiming Wang, Zhen Liu, Yufeng Guo   +4 more
doaj   +2 more sources

Near Infrared Responsive Gold Nanorods Attenuate Osteoarthritis Progression by Targeting TRPV1

Advanced Science
Osteoarthritis (OA) is the most common degenerative joint disease worldwide, with the main pathological manifestation of articular cartilage degeneration. It have been investigated that pharmacological activation of transient receptor potential vanilloid
Weitong Li, Zhongyang Lv, Peng Wang, Ya Xie, Wei Sun, Hu Guo, Xiaoyu Jin, Yuan Liu, Ruiyang Jiang, Yuxiang Fei, Guihua Tan, Huiming Jiang, Xucai Wang, Zizheng Liu, Zheng Wang, Nuo Xu, Wenli Gong, Rui Wu, Dongquan Shi   +18 more
doaj   +2 more sources

Bifunctional TRPV1 Targeted Magnetothermal Switch to Attenuate Osteoarthritis Progression

Research
Transient receptor potential vanilloid family member 1 (TRPV1) has been revealed as a therapeutic target of osteoarthritis (OA), the most common deteriorating whole joint disease, by impeding macrophagic inflammation and chondrocytes ferroptosis. However,
Zhongyang Lv, Peng Wang, Weitong Li, Ya Xie, Wei Sun, Xiaoyu Jin, Ruiyang Jiang, Yuxiang Fei, Yuan Liu, Tianshu Shi, Hu Guo, Ziying Sun, Jintao Lin, Xucai Wang, Guihua Tan, Yizhang Wu, Nirong Bao, Dongquan Shi   +17 more
doaj   +2 more sources

The role of TRPV1 ion channels in the suppression of gastric cancer development

Journal of Experimental & Clinical Cancer Research, 2020
Background Although the aberrant expression and function of most Ca2+-permeable channels are known to promote gastrointestinal tumors, the association between transient receptor potential vanilloid receptor 1 (TRPV1) channels and gastric cancer (GC) has ...
Nannan Gao, Feng Yang, Siyuan Chen, Hanxing Wan, Xiaoyan Zhao, Hui Dong   +5 more
doaj   +2 more sources

Transient receptor potential vanilloid type-1 regulates periodontal disease damage via the PI3K/AKT signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): This study aimed to investigate the function of transient receptor potential vanilloid 1 (TRPV1) in regulating periodontal lesions. In addition, we explored the underlying mechanism of the phosphatidylinositol 3-kinase/protein kinase B ...
xiaolu xu, Yue-heng Li, Zhengyan Yang, Zhi Zhou   +3 more
doaj   +1 more source

Apoptosis Induction Through Increased TRPV1 Activation by Synergic Effect of Melatonin and Doxorubicin in Human Osteosarcoma and Chondrosarcoma Cell Lines

Acta Medica Alanya, 2023
Aim: We aimed to reveal the role of doxorubicin (Dox), melatonin (Mel) and transient receptor potential Vanilloid 1 (TRPV1) channels in bone and cartilage cancer cells during the treatment process.
Anıl Gülcü, İshak Suat Övey, Ahmet Koçak   +2 more
doaj   +1 more source

Thermo-sensitive TRP channels and prevention of major chronic diseases

Di-san junyi daxue xuebao, 2022
American scientists David Julius and Ardem Patapoutian won the Nobel Prize in physiology or medicine in 2021 for their groundbreaking discoveries of capsaicin receptor TRPV1 and menthol receptor TRPM8, revealing the secrets of temperature perception. The
ZHU Zhiming, LIU Daoyan
doaj   +1 more source

Electroacupuncture reduces chronic fibromyalgia pain through attenuation of transient receptor potential vanilloid 1 signaling pathway in mouse brains [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Fibromyalgia pain is a mysterious clinical pain syndrome, characterized by inflammation in the brain, whose molecular mechanisms are still unknown.
Chia-Ming Yen, Ching-Liang Hsieh, Yi-Wen Lin   +2 more
doaj   +1 more source

Human TRPV1 structure and inhibition by the analgesic SB-366791

Nature Communications, 2023
Pain therapy has remained conceptually stagnant since the opioid crisis, which highlighted the dangers of treating pain with opioids. An alternative addiction-free strategy to conventional painkiller-based treatment is targeting receptors at the origin ...
A. Neuberger, Mai Oda, Yury A. Nikolaev, K. Nadezhdin, Elena O. Gracheva, Sviatoslav N. Bagriantsev, A. Sobolevsky   +6 more
semanticscholar   +1 more source

TRPV1 activation induces cell death of TM3 mouse Leydig cells

Journal of Animal Reproduction and Biotechnology, 2021
The role of transient receptor potential vanilloid receptor-1 (TRPV1) has been primarily investigated in pain sensory neurons. Relatively, little research has been performed in testicular cells.
Eun-Jin Kim, Long Cao Dang, Marie Merci Nyiramana, Adrian S. Siregar, Min-Seok Woo, Chang-Woon Kim, Dawon Kang   +6 more
doaj   +1 more source