Results 171 to 180 of about 42,288 (305)

TRPV1 Supports Axogenic Enhanced Excitability in Response to Neurodegenerative Stress [PDF]

, 2021
Michael L. Risner, Nolan R. McGrady, Andrew M. Boal, Silvia Pasini, David J. Calkins   +4 more
openalex   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control

The Journal of Physiology, EarlyView.
Richard J. A. Wilson, Nicholas Jendzjowsky   +1 more
wiley   +1 more source

Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li, Fulong Man, Jianwei Cheng, Li Chen, Yongyong Li, Haiqing Dong   +5 more
wiley   +1 more source

Inhibition of fatty acid amide hydrolase unmasks CB₁receptor and TRPV1 channel‐mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey [PDF]

, 2010
H. Kawahara, GM Drew, MacDonald J. Christie, Christopher W. Vaughan   +3 more
openalex   +1 more source

When the brain listens to the kidney, is it TRP'n or what?

The Journal of Physiology, EarlyView.
John W. Osborn, Louise C. Evans, Christopher T. Banek, Lucy Vulchanova, Alex Dayton   +4 more
wiley   +1 more source

Cannabidiol Lacks Direct Effect on Cortical Excitability: A Randomized, Double Blind, Placebo Controlled, 3‐Way Crossover Trial

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 147-157, January 2026.
Cannabidiol (CBD) is approved as an adjunctive treatment of seizures associated with Dravet syndrome, Lennox–Gastaut Syndrome, and tuberous sclerosis. Its therapeutic and adverse effects are thought to arise, at least partly, from a pharmacokinetic interaction with clobazam, another anti‐seizure medication (ASM).
Andriy A. Gorbenko, Catherine M.K.E. de Cuba, Annika A. de Goede, Titiaan E. Post, Roman Bohoslavsky, Pamela K. Strugala, Jules A.A.C. Heuberger, Geert Jan Groeneveld   +7 more
wiley   +1 more source

(420) NEO6860, a novel modality selective TRPV1 antagonist: results from a phase I, double-blind, placebo-controlled study in healthy subjects [PDF]

, 2016
D. Chiche, W. A. Brown, Philippe Walker
openalex   +1 more source

Reduced Descending Itch Inhibition in Peripheral Neuropathy Patients With Chronic Pruritus

European Journal of Pain, Volume 30, Issue 1, January 2026.
ABSTRACT Background Peripheral neuropathies (PNP) cause a wide range of symptoms of which pruritus and pain are a major burden to patients. Clarifying their mechanisms will facilitate the adequate symptom management. In contrast to neuropathic pain, neuropathic pruritus has long been understudied.
Jonas Eck, Stephan Bigalke, Martin Schmelz, Daniela Constanze Rosenberger, Bruno Pradier, Frank Rutsch, Claudia Sommer, Frank Birklein, Daniel Segelcke, Esther Pogatzki‐Zahn   +9 more
wiley   +1 more source

Extent of intrinsic disorder and NMR chemical shift assignments of the distal N-termini from human TRPV1, TRPV2 and TRPV3 ion channels [PDF]

, 2022
Christoph Wiedemann, Benedikt Goretzki, Zoe N. Merz, Frederike Tebbe, Pauline Schmitt, Ute A. Hellmich   +5 more
openalex   +1 more source