Results 11 to 20 of about 42,288 (305)

Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation [PDF]

Nature Communications, 2023
The survival of malignant tumors is highly dependent on their intrinsic self-defense pathways such as heat shock protein (HSP) during cancer therapy. However, precisely dismantling self-defenses to amplify antitumor potency remains unexplored. Herein, we
Ting Li, Shuhui Jiang, Ying Zhang, Jie Luo, Ming Li, H. Ke, Yibin Deng, Tao Yang, Xiaohui Sun, Huabing Chen   +9 more
semanticscholar   +2 more sources

TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer’s Disease-Associated Pathology and Cognitive Decline [PDF]

Frontiers in Pharmacology, 2022
Autophagy is a major regulator of the ageing process of the central nervous system and neurodegeneration. Autophagy dysfunction has been implicated in the pathogenesis of Alzheimer’s disease (AD).
Chenfei Wang, Wei Huang, Jia Lu, Hongzhuan Chen, Zhihua Yu   +4 more
semanticscholar   +2 more sources

TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors

Cell Reports, 2022
Summary: The molecular mechanism underlying the functional interaction between H1R and TRPV1 remains unclear. We show here that H1R directly binds to the carboxy-terminal region of TRPV1 at residues 715–725 and 736–749.
Yingwei Gao, Ruining Ma, Weiji Weng, Heng Zhang, Yingping Wang, Rongjun Guo, Xiaokun Gu, Yang Yang, Fan Yang, Aiwu Zhou, Jinke Cheng, Zhe-Yu Chen, Michael X. Zhu, Yong Li   +13 more
doaj   +3 more sources

TRPV1 in Dry Eye Disease

Frontiers in Bioscience-Landmark
Dry eye disease (DED) is a prevalent ophthalmic ailment with intricate pathogenesis and that occurs primarily due to various factors which affect the ocular surface.
Qingqing Gou, Zhi Song, Yu Gong, Jiawen Li   +3 more
doaj   +3 more sources

Activation of GPR18 by Resolvin D2 Relieves Pain and Improves Bladder Function in Cyclophosphamide-Induced Cystitis Through Inhibiting TRPV1

Drug Design, Development and Therapy, 2021
Qudong Lu,1 Yang Yang,1 Hengshuai Zhang,1 Cheng Chen,2 Jiang Zhao,1 Zhenxing Yang,1 Yi Fan,1 Longkun Li,1 Huan Feng,1 Jingzhen Zhu,1 Shanhong Yi1 1Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, 400037, People’s ...
Lu Q, Yang Y, Zhang H, Chen C, Zhao J, Yang Z, Fan Y, Li L, Feng H, Zhu J, Yi S   +10 more
doaj   +3 more sources

Leveraging TRPV1 for intracellular delivery of membrane impermeant compounds in the brain. [PDF]

Sci Rep
Zepeda JC, Peeters LD, Adapa PS, Kassaye BB, Grueter BA.   +4 more
europepmc   +3 more sources

TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases

Frontiers in Pharmacology, 2023
TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of exogenous or endogenous inflammatory mediators, triggering neuropeptide
Tengfei Xiao, Mingzhong Sun, Chuanxiang Zhao, Jingjing Kang   +3 more
semanticscholar   +1 more source

Dihydrocapsiate does not increase energy expenditure nor fat oxidation during aerobic exercise in men with overweight/obesity: a randomized, triple-blinded, placebo-controlled, crossover trial

Journal of the International Society of Sports Nutrition, 2022
Background Prior evidence suggests that capsinoids ingestion may increase resting energy expenditure (EE) and fat oxidation (FATox), yet whether they can modulate those parameters during exercise conditions remains poorly understood. We hypothesized that
Francisco J. Osuna-Prieto, Francisco M. Acosta, Unai A. Perez de Arrilucea Le Floc’h, Blanca Riquelme-Gallego, Elisa Merchan-Ramirez, Huiwen Xu, Juan Carlos De La Cruz-Márquez, Francisco J. Amaro-Gahete, Jose M. Llamas-Elvira, Eva M. Triviño-Ibáñez, Antonio Segura-Carretero, Jonatan R Ruiz   +11 more
doaj   +1 more source

The science of “smell” and the noble for “hugs:” making “sense?”

Asian Journal of Medical Sciences, 2021
David Julius and Ardem Patapoutian were jointly awarded the 2021 Nobel Prize in Physiology and Medicine for their discoveries of receptors for temperature and touch.
Ruby Dhar , Arun Kumar , Subhradip Karmakar   +2 more
doaj   +1 more source

TRPV1 regulates ApoE4-disrupted intracellular lipid homeostasis and decreases synaptic phagocytosis by microglia

Experimental and Molecular Medicine, 2023
A chili pepper extract that activates a sensory protein helps to improve lipid metabolism in immune cells in the brain, leading to better nerve cell health in a mouse model of Alzheimer’s disease.
Chenfei Wang, Jia Lu, Xudong Sha, Yu Qiu, Hongzhuan Chen, Zhihua Yu   +5 more
semanticscholar   +1 more source