Results 11 to 20 of about 25,827 (208)
TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors
Cell Reports, 2022 Summary: The molecular mechanism underlying the functional interaction between H1R and TRPV1 remains unclear. We show here that H1R directly binds to the carboxy-terminal region of TRPV1 at residues 715–725 and 736–749.
Yingwei Gao +13 more
doaj +3 more sources
Frontiers in Bioscience-LandmarkDry eye disease (DED) is a prevalent ophthalmic ailment with intricate pathogenesis and that occurs primarily due to various factors which affect the ocular surface.
Qingqing Gou +3 more
doaj +3 more sources
Frontiers in Bioscience-Landmark, 2021 Tetrahydropalmatine (dl-THP) demonstrates an analgesic effect in animal models of neuropathic and inflammatory pain, however, the underlying mechanisms of its pharmacological action within the spinal cord remains unclear. Both P2X3 receptor and TRPV1 are
Yan Wang +8 more
doaj +1 more source
Expression of TRPV1 as A Heat Sensitive Voltage-Dependent Ion Channel and Oxidative Stress in Sperm Samples of Infertile Men with Varicocele: A Case-Control Study [PDF]
Cell Journal, 2022 Objective: Transient receptor potential vanilloid 1 (TRPV1) is a heat-activated nonselective cation channel that playsimportant role in the spermatogenesis, capacitation, acrosome reaction and sperm/oocyte fusion.
Sahar Salahshouri +4 more
doaj +1 more source
Targeting TRPV1 for Body Weight Control using TRPV1−/− Mice and Electroacupuncture [PDF]
Scientific Reports, 2015 AbstractObesity is a global social medical problem resulting in morbidity as high as 20–30%. Here we investigated whether the manipulation of TRPV1 can control mice body weight through electroacupuncture (EA). The results demonstrated that body weight increased with time in the control group (108.19 ± 1.31%, n = 7). The increase of mice body weight was
Monchanok Choowanthanapakorn +4 more
openaire +2 more sources
Urothelial TRPV1: TRPV1-Reporter Mice, a Way to Clarify the Debate? [PDF]
Frontiers in Physiology, 2012 The urothelium is a complex and dynamic epithelial layer with a sensory role contributing to mechano- and chemosensation in the bladder. This primary source of sensory inputs modulates micturition via an urothelial–sensory fibers crosstalk. The communication is mediated by ATP and NO release from epithelial cells.
Mathieu eBoudes +2 more
openaire +3 more sources
Journal of Pain Research, 2023 Christie RA Leite-Panissi,1 Bruna B De Paula,2 John K Neubert,3 Robert M Caudle2 1Department of Psychology, School of Philosophy, Science and Literature of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil; 2Department of Oral and ...
Leite-Panissi CR +3 more
doaj
Thorax, 2004 Iodo-resiniferatoxin, a new TRPV1 inhibitor, shows promising antitussive activity in an animal model Cough is one of the most common respiratory complaints and intractable cough remains one of the most distressing and difficult to treat conditions of the lung.
openaire +2 more sources
Nanoparticles-Mediated Modulation of TRP Channels: Advances and Therapeutic Potential. [PDF]
Wiley Interdiscip Rev Nanomed NanobiotechnolNanoparticle‐mediated modulation of TRP channels, highlighting the interplay between external stimuli, tailored nanomaterials, and TRP channel activation across a range of physiological contexts. This review examines the roles of TRP channels in cellular signaling and disease, providing insights into how advances in nanotechnology can facilitate ...
Foster KA +3 more
europepmc +2 more sources
Monoacylglycerols Activate TRPV1 – A Link between Phospholipase C and TRPV1
PLoS ONE, 2013 Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms. Here we explored the possibility that the diacylglycerol metabolites 2-arachidonoylglycerol and 1-arachidonoylglycerol, and not metabolites of
Zygmunt, Peter +12 more
openaire +8 more sources