Results 21 to 30 of about 42,288 (305)

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway

Cell Death and Disease, 2021
Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven synovitis exacerbates the pathological process. However, precise therapies for M1 macrophage to decrease synovitis and attenuate OA progression have been ...
Z. Lv, Xingquan Xu, Zi-ying Sun, Y. Yang, Hu Guo, Jiawei Li, Kuo-yang Sun, Rui Wu, Jia Xu, Q. Jiang, S. Ikegawa, D. Shi   +11 more
semanticscholar   +1 more source

Ablation of TRPV1-positive nerves exacerbates salt-induced hypertension and tissue injury in rats after renal ischemia-reperfusion via infiltration of macrophages

Clinical and Experimental Hypertension, 2021
Background: High-salt intake after renal ischemia/reperfusion (I/R) injury leads to hypertension and further renal injury, but the mechanisms are largely unknown.
Shuang-Quan Yu, Shuangtao Ma, Donna H. Wang   +2 more
doaj   +1 more source

TRPV1 inhibition overcomes cisplatin resistance by blocking autophagy-mediated hyperactivation of EGFR signaling pathway

Nature Communications, 2023
Cisplatin resistance along with chemotherapy-induced neuropathic pain is an important cause of treatment failure for many cancer types and represents an unmet clinical need.
S. Oh, J. Lim, Min Kyu Son, Jun Hyeok Ahn, Kwon-Ho Song, Hyo-Jung Lee, Su-Ya Kim, Eunho Cho, J. Chung, Hanbyoul Cho, Hyo-Rim Kim, Jae-Hoon Kim, J. Park, Jungmin Choi, S. Hwang, Tae Woo Kim   +15 more
semanticscholar   +1 more source

Expression of TRPV1 as A Heat Sensitive Voltage-Dependent Ion Channel and Oxidative Stress in Sperm Samples of Infertile Men with Varicocele: A Case-Control Study [PDF]

Cell Journal, 2022
Objective: Transient receptor potential vanilloid 1 (TRPV1) is a heat-activated nonselective cation channel that playsimportant role in the spermatogenesis, capacitation, acrosome reaction and sperm/oocyte fusion.
Sahar Salahshouri, Fahimeh Akbarian, Marziyeh Tavalaee, Seyed Morteza Seifati, Mohammad Hossein Nasr Esfahani   +4 more
doaj   +1 more source

Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia

Nature Communications, 2023
TRPV1 as a drug target suffers from side effects of hypothermia. Here, authors engineer a peptide, sRhTx, as a positive allosteric modulator of TRPV1 channel. It potentiates the activity of TRPV1 to reversibly ablate pain-sensing nerve terminals for long-
Heng Zhang, Jianmin Lin, Ya-Kai Xie, Xiu-Zu Song, Jiayi Sun, Beilei Zhang, Yun-Kun Qi, Zhen-Zhong Xu, Fan Yang   +8 more
semanticscholar   +1 more source

Analgesic effect of dl-THP on inflammatory pain mediated by suppressing spinal TRPV1 and P2X3 receptors in rats

Frontiers in Bioscience-Landmark, 2021
Tetrahydropalmatine (dl-THP) demonstrates an analgesic effect in animal models of neuropathic and inflammatory pain, however, the underlying mechanisms of its pharmacological action within the spinal cord remains unclear. Both P2X3 receptor and TRPV1 are
Yan Wang, Rui-Rui Wang, Wei Sun, Chao Lou, Fan Yang, Ting He, Xiao-Liang Wang, Fa-Le Cao, Jun Chen   +8 more
doaj   +1 more source

The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis

Gut Microbes, 2021
Ferroptosis, a new type of cell death has been found to aggravate intestinal ischemia/reperfusion (I/R) injury. However, little is known about the changes of gut microbiota and metabolites in intestinal I/R and the role of gut microbiota metabolites on ...
Fan Deng, Bing-Cheng Zhao, Xiao Yang, Ze-Bin Lin, Qi-Shun Sun, Yi-Fan Wang, Zheng-Zheng Yan, Wei-Feng Liu, Cai Li, Jing-Juan Hu, Ke-Xuan Liu   +10 more
doaj   +1 more source

TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease

EMBO Reports, 2021
As the brain‐resident innate immune cells, reactive microglia are a major pathological feature of Alzheimer's disease (AD). However, the exact role of microglia is still unclear in AD pathogenesis.
Jia Lu, Wei Zhou, Fangfang Dou, Chenfei Wang, Zhihua Yu   +4 more
semanticscholar   +1 more source

The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review

International Journal on Biological Sciences, 2021
The transient receptor potential cation channel subfamily V member 1 (TRPV1) is a transmembrane protein that can be activated by various physical and chemical stimuli and is associated with pain transduction. In recent years, TRPV1 was discovered to play
Li Li, Cheng Chen, Chengyao Chiang, Tian Xiao, Yangchao Chen, Yongxiang Zhao, Duo Zheng   +6 more
semanticscholar   +1 more source

Beyond Neuronal Heat Sensing: Diversity of TRPV1 Heat-Capsaicin Receptor-Channel Functions

Frontiers in Cellular Neuroscience, 2021
Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and related chemicals from the group of vanilloids as well as by noxious
Y. Shuba
semanticscholar   +1 more source