Results 21 to 30 of about 25,827 (208)

Acupoint Catgut Embedding Diminishes Fibromyalgia Pain through TRPV1 in the Mouse Brain

Journal of Integrative Neuroscience, 2023
Background: Chronic pain refers to pain that persists for over three months. Chronic pain may restrict activities of daily living, including work, learning, social life, and can lead to anxiety, depression, and sleep disturbance.
Po-Chih Lai, Chia-Ming Yen, I-Han Hsiao, Yung-Hsiang Chen, Yi-Wen Lin   +4 more
doaj   +1 more source

The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a+/− Mouse Model of Dravet Syndrome

Frontiers in Pharmacology, 2021
Cannabidiol has been approved for the treatment of drug-resistant childhood epilepsies including Dravet syndrome (DS). Although the mechanism of anticonvulsant action of cannabidiol is unknown, emerging data suggests involvement of the transient receptor
Vaishali Satpute Janve, Vaishali Satpute Janve, Lyndsey L. Anderson, Lyndsey L. Anderson, Dilara Bahceci, Dilara Bahceci, Nicole A. Hawkins, Jennifer A. Kearney, Jonathon C. Arnold, Jonathon C. Arnold   +9 more
doaj   +1 more source

Identification and Quantification of Transient Receptor Potential Vanilloid 1 (TRPV1) in Equine Articular Tissue

Animals, 2020
Joint pain and osteoarthritis (OA) are some of the most common causes of lameness in horses, and most of the available treatments focus on symptomatic relief without a disease-modifying effect.
Anne Frank Gallagher vom Braucke, Nanna Lysemose Frederiksen, Lise Charlotte Berg, Stacie Aarsvold, Felix Christoph Müller, Mikael Ploug Boesen, Casper Lindegaard   +6 more
doaj   +1 more source

Effects of different phenylcapsaicin doses on resistance training performance, muscle damage, protein breakdown, metabolic response, ratings of perceived exertion, and recovery: a randomized, triple-blinded, placebo-controlled, crossover trial

Journal of the International Society of Sports Nutrition, 2023
Background The aim of this study was to explore the effects of a low dose (LD) of 0.625 mg and a high dose (HD) of 2.5 mg of phenylcapsaicin (PC) on full squat (SQ) performance, active muscle (RPE-AM) and overall body (RPE-OB) ratings of perceived ...
Pablo Jiménez-Martínez, Pedro Jesús Cornejo-Daza, Juan Sánchez-Valdepeñas, Iván Asín-Izquierdo, Clara Cano-Castillo, Carlos Alix-Fages, Fernando Pareja-Blanco, Juan C. Colado   +7 more
doaj   +1 more source

EFFECT OF EXERCISE ON TRPV1 EXPRESSION IN THE MUSCLE OF GALUR WISTAR RATS

Jurnal Kedokteran Diponegoro
Background: Exercise is an activity that induces acid generation as one of the TRPV1 stimulants. Activation of TRPV1, a pain receptor, by acid, can lead to the formation of neuropeptides such as substance P and calcitonin gene-related peptides as a cause
Hanna Goenawan, Raisa Zahra, Putri Teesa Radhiyanti, Julia Ramadhanti, Vita Murniati Tarawan, Fifi Veronica   +5 more
doaj   +1 more source

The mechanism of heat stress-induced injury in the immature oocytes of zebrafish (Danio rerio)

The Journal of Reproduction and Development
Immature zebrafish oocytes are highly susceptible to high temperatures, making it difficult to warm cryopreserved oocytes rapidly. In the present study, we aimed to investigate whether thermosensitive channels, lipid mediators, and ferroptosis ...
Yanuar ACHADRI, Nao KUWAHARA, Momoko KIMURA, Nami KANAMARU, Kazutsugu MATSUKAWA, Keisuke EDASHIGE   +5 more
doaj   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Diverse TRPV1 responses to cannabinoids [PDF]

Channels, 2019
Cannabinoid compounds are potential analgesics. Users of medicinal Cannabis report efficacy for pain control, clinical studies show that cannabis can be effective and opioid sparing in chronic pain, and some constituent cannabinoids have been shown to target nociceptive ion channels. Here, we explore and compare a suite of cannabinoids for their impact
J. Starkus, C. Jansen, L. M. N. Shimoda, A. J. Stokes, A. L. Small-Howard, H. Turner   +5 more
openaire   +2 more sources

TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes

Scientific Reports, 2021
The non-selective cation channel transient receptor potential vanilloid 1 (TRPV1) is expressed throughout the cardiovascular system. Recent evidence shows a role for TRPV1 in inflammatory processes.
Katherine Sattler, Ibrahim El-Battrawy, Lukas Cyganek, Siegfried Lang, Huan Lan, Xin Li, Zhihan Zhao, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiaobo Zhou, Ibrahim Akin   +11 more
doaj   +1 more source

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy

Advanced Science, EarlyView.
Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih, Nicolas L.A. Dumaire, Clémence Gieré, Erin Vest, Haya Alkhateeb, Christian P. Moritz, Yannick Tholance, Jean‐Philippe Camdessanché, Jean‐Christophe Antoine, Jérôme Honnorat, Jafar Kafaie, Liberty François‐Moutal, Aubin Moutal   +12 more
wiley   +1 more source