Results 31 to 40 of about 42,288 (305)
TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons
bioRxiv, 2022 TRPV1, a capsaicin- and heat-sensitive ion channel, is expressed by peripheral nociceptors and has been implicated in various inflammatory and neuropathic pain conditions.
W. W. Yue +4 more
semanticscholar +1 more source
Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis
Nature Communications, 2022 Single particle cryo-EM often yields multiple protein conformations within a single dataset, but experimentally deducing the temporal relationship of these conformers within a conformational trajectory is not trivial.
D. H. Kwon +4 more
semanticscholar +1 more source
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
Nature, 2013 Transient receptor potential (TRP) channels are sensors for a wide range of cellular and environmental signals, but elucidating how these channels respond to physical and chemical stimuli has been hampered by a lack of detailed structural information ...
M. Liao, E. Cao, D. Julius, Yifan Cheng
semanticscholar +1 more source
Targeting TRPV1 for Body Weight Control using TRPV1−/− Mice and Electroacupuncture [PDF]
Scientific Reports, 2015 AbstractObesity is a global social medical problem resulting in morbidity as high as 20–30%. Here we investigated whether the manipulation of TRPV1 can control mice body weight through electroacupuncture (EA). The results demonstrated that body weight increased with time in the control group (108.19 ± 1.31%, n = 7). The increase of mice body weight was
Monchanok Choowanthanapakorn +4 more
openaire +2 more sources
Urothelial TRPV1: TRPV1-Reporter Mice, a Way to Clarify the Debate? [PDF]
Frontiers in Physiology, 2012 The urothelium is a complex and dynamic epithelial layer with a sensory role contributing to mechano- and chemosensation in the bladder. This primary source of sensory inputs modulates micturition via an urothelial–sensory fibers crosstalk. The communication is mediated by ATP and NO release from epithelial cells.
Mathieu eBoudes +2 more
openaire +3 more sources
TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia
Cell Death and Disease, 2021 Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome is considered an important regulator of immunity and inflammation, both of which play a critical role in MS.
Yahui Zhang +13 more
semanticscholar +1 more source
Journal of Pain Research, 2023 Christie RA Leite-Panissi,1 Bruna B De Paula,2 John K Neubert,3 Robert M Caudle2 1Department of Psychology, School of Philosophy, Science and Literature of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil; 2Department of Oral and ...
Leite-Panissi CR +3 more
doaj
Thorax, 2004 Iodo-resiniferatoxin, a new TRPV1 inhibitor, shows promising antitussive activity in an animal model Cough is one of the most common respiratory complaints and intractable cough remains one of the most distressing and difficult to treat conditions of the lung.
openaire +2 more sources
Nature Metabolism, 2021 Brown adipose tissue (BAT) and beige fat function in energy expenditure in part due to their role in thermoregulation, making these tissues attractive targets for treating obesity and metabolic disorders.
F. Shamsi +7 more
semanticscholar +1 more source
Monoacylglycerols Activate TRPV1 – A Link between Phospholipase C and TRPV1
PLoS ONE, 2013 Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms. Here we explored the possibility that the diacylglycerol metabolites 2-arachidonoylglycerol and 1-arachidonoylglycerol, and not metabolites of
Zygmunt, Peter +12 more
openaire +8 more sources