Results 41 to 50 of about 42,288 (305)
Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation
Cells, 2021 Capsaicin is a potent agonist of the Transient Receptor Potential Vanilloid type 1 (TRPV1) channel and is a common component found in the fruits of the genus Capsicum plants, which have been known to humanity and consumed in food for approximately 7000 ...
Sreepadaarchana Munjuluri +5 more
semanticscholar +1 more source
Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1
International Journal of Molecular Sciences, 2021 In addition to the sense of taste and olfaction, chemesthesis, the sensation of irritation, pungency, cooling, warmth, or burning elicited by spices and herbs, plays a central role in food consumption.
M. Rhyu, Yiseul Kim, V. Lyall
semanticscholar +1 more source
Acupoint Catgut Embedding Diminishes Fibromyalgia Pain through TRPV1 in the Mouse Brain
Journal of Integrative Neuroscience, 2023 Background: Chronic pain refers to pain that persists for over three months. Chronic pain may restrict activities of daily living, including work, learning, social life, and can lead to anxiety, depression, and sleep disturbance.
Po-Chih Lai +4 more
doaj +1 more source
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
Nature, 2016 When integral membrane proteins are visualized in detergents or other artificial systems, an important layer of information is lost regarding lipid interactions and their effects on protein structure.
Yuan Gao, E. Cao, D. Julius, Yifan Cheng
semanticscholar +1 more source
The interaction of TRPV1 and lipids: Insights into lipid metabolism
Frontiers in Physiology, 2022 Transient receptor potential vanilloid 1 (TRPV1), a non-selective ligand-gated cation channel with high permeability for Ca2+, has received considerable attention as potential therapeutic target for the treatment of several disorders including pain ...
S. Abdalla +3 more
semanticscholar +1 more source
TRPV1: Structure, Endogenous Agonists, and Mechanisms
International Journal of Molecular Sciences, 2020 The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel.
Miguel Benítez-Angeles +3 more
semanticscholar +1 more source
TRPV1: Role in Skin and Skin Diseases and Potential Target for Improving Wound Healing
International Journal of Molecular Sciences, 2021 Skin is innervated by a multitude of sensory nerves that are important to the function of this barrier tissue in homeostasis and injury. The role of innervation and neuromediators has been previously reviewed so here we focus on the role of the transient
M. D. Bagood, R. Isseroff
semanticscholar +1 more source
Frontiers in Pharmacology, 2021 Cannabidiol has been approved for the treatment of drug-resistant childhood epilepsies including Dravet syndrome (DS). Although the mechanism of anticonvulsant action of cannabidiol is unknown, emerging data suggests involvement of the transient receptor
Vaishali Satpute Janve +9 more
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Extracellular cap domain is an essential component of the TRPV1 gating mechanism
Nature Communications, 2021 Transient receptor potential (TRP) channels are polymodal molecular sensors involved in numerous physiological processes and implicated in a variety of human diseases.
K. Nadezhdin +6 more
semanticscholar +1 more source
Journal of the International Society of Sports Nutrition, 2023 Background The aim of this study was to explore the effects of a low dose (LD) of 0.625 mg and a high dose (HD) of 2.5 mg of phenylcapsaicin (PC) on full squat (SQ) performance, active muscle (RPE-AM) and overall body (RPE-OB) ratings of perceived ...
Pablo Jiménez-Martínez +7 more
doaj +1 more source