Results 61 to 70 of about 42,288 (305)

Inflammation, Cancer and Immunity—Implication of TRPV1 Channel

Frontiers in Oncology, 2019
Process of inflammation and complex interactions between immune and cancer cells within tumor microenvironment are known to drive and shape the outcome of the neoplastic disease. Recent studies increasingly show that ion channels can be used as potential
J. Bujak, Daria Kosmala, I. Szopa, K. Majchrzak, P. Bednarczyk   +4 more
semanticscholar   +1 more source

Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19

International Archives of Allergy and Immunology, 2021
In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce
J. Bousquet, W. Czarlewski, T. Zuberbier, J. Mullol, H. Blain, J. Cristol, R. de la Torre, Nieves Pizarro Lozano, V. Le Moing, A. Bedbrook, I. Agache, C. Akdis, G. Canonica, Á. Cruz, A. Fiocchi, J. Fonseca, S. Fonseca, B. Gemicioğlu, T. Haahtela, G. Iaccarino, J. Ivancevich, M. Jutel, L. Klimek, H. Kraxner, P. Kuna, D. Larenas-Linnemann, A. Martineau, E. Mélen, Y. Okamoto, N. Papadopoulos, O. Pfaar, F. Regateiro, J. Reynes, Y. Rolland, P. Rouadi, B. Samoliński, A. Sheikh, S. Toppila-Salmi, A. Valiulis, Hak-Jong Choi, H. J. Kim, J. Anto   +41 more
semanticscholar   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

Advanced Science, EarlyView.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
wiley   +1 more source

Response to High-Dose Topical Capsaicin in Neuropathic Pain: Absence of Deep Pain as a Predictor of Analgesic Effect. [PDF]

Eur J Pain
ABSTRACT Background Topical high‐dose capsaicin treatment is a recommended therapy for localised neuropathic pain with good tolerability and no identified drug interactions. However, it is not effective for every patient. So far, few parameters in patient history have been identified as predictors for response to capsaicin treatment.
Sendel M, Ehmke L, Dunst A, Vollert J, Bruckmüller H, Brügge S, Rehm S, Gierthmühlen J, Kersebaum D, Cascorbi I, Baron R, Forstenpointner J.   +11 more
europepmc   +2 more sources

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Dose-Related Inhibition of Capsaicin Responses by Cannabinoids CBG, CBD, THC and their Combination in Cultured Sensory Neurons

Journal of Pain Research, 2021
Uma Anand,1 Christian Oldfield,1 Barbara Pacchetti,2 Praveen Anand,1 Mikael H Sodergren1,2 1Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, W12 ONN, UK; 2EMMAC Life Sciences Ltd, London, UKCorrespondence: Uma AnandFaculty of ...
Anand U, Oldfield C, Pacchetti B, Anand P, Sodergren MH   +4 more
doaj  

Targeting TRP channels: beyond TRPV1 [PDF]

Naunyn-Schmiedeberg's Archives of Pharmacology, 2015
This theme issue of Naunyn-Schmiedeberg’s Archives of Pharmacology contains six review articles covering recent advances in our understanding of the potential pharmacological roles of different transient receptor potential (TRP) ion channel subtypes that can be targeted for the therapeutic use.
Arthur, Gomtsyan, Arpad, Szallasi
openaire   +2 more sources

Induced Proprioceptor and Low‐Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties

Advanced Science, EarlyView.
This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme, Rocio K. Finol‐Urdaneta, Jeffrey R. McArthur, Nicholas R. Marzano, Simon Maksour, Amarinder Thind, Yang Guo, Dominic Kaul, Marnie Maddock, Oliver Friedrich, Boris Martinac, David J. Adams, Mirella Dottori   +12 more
wiley   +1 more source

Sensitive Skin Syndrome in Children with Atopic Dermatitis: Pathogenesis and Management Features

Вопросы современной педиатрии, 2019
The atopic dermatitis (AD) is common skin disease and has significant impact on patients and their families quality of life. In recent years the term “sensitive skin" has been used more frequently. It is separate syndrome with subjective perception (such
Nikolay N. Murashkin, Roman V. Epishev, Dmitri V. Fedorov, Alexander I. Materikin, Eduard T. Ambarchyan, Leonid A. Opryatin, Alena A. Savelova, Roman A. Ivanov, Wasel Ahmad   +8 more
doaj   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source