Results 81 to 90 of about 42,288 (305)

Fiber‐type soft bioelectronics for wearable and implantable sensing and therapy

BMEMat, EarlyView.
Fiber‐type soft bioelectronics are emerging as versatile platforms for wearable and implantable health monitoring and therapeutic applications. These bioelectronics use organic and inorganic matrices combined with advanced fillers, which feature high conductivity, electrochemical sensitivity, softness, and biocompatibility.
Haneul Kim, Hak Yong Kim, Ja Hoon Koo, Gi Doo Cha, Dae‐Hyeong Kim, Hye Jin Kim   +5 more
wiley   +1 more source

Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS

Gut, 2020
Objective Resolvins (RvD1, RvD2 and RvE1) are endogenous anti-inflammatory lipid mediators that display potent analgesic properties in somatic pain by modulating transient receptor potential vanilloid 1 (TRPV1) activation.
E. Perna, J. Aguilera-Lizarraga, M. Florens, P. Jain, Stavroula A Theofanous, Nikita Hanning, J. D. De Man, M. Berg, Benedicte Y. De Winter, Y. A. Alpizar, K. Talavera, P. Vanden Berghe, M. Wouters, G. Boeckxstaens   +13 more
semanticscholar   +1 more source

Contributions of Different Modes of TRPV1 Activation to TRPV1 Antagonist-Induced Hyperthermia [PDF]

The Journal of Neuroscience, 2010
Transient receptor potential vanilloid-1 (TRPV1) antagonists are widely viewed as next-generation pain therapeutics. However, these compounds cause hyperthermia, a serious side effect. TRPV1 antagonists differentially block three modes of TRPV1 activation: by heat, protons, and chemical ligands (e.g., capsaicin).
Andras, Garami, Yury P, Shimansky, Eszter, Pakai, Daniela L, Oliveira, Narender R, Gavva, Andrej A, Romanovsky   +5 more
openaire   +2 more sources

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Bibliometric Analysis of Global Research on Transient Receptor Potential Vanilloid 1 in the Field of Pain

Journal of Pain Research, 2023
Sisi Wang,1 Wen Wang,2 Xiangming Ye1 1Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital,
Wang S, Wang W, Ye X
doaj  

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

The Association Between Long-Term Spicy-Food Consumption and the Incidence of Chronic Postsurgical Pain After Cesarean Delivery: An Observational Study

Journal of Pain Research, 2022
Zhuoxi Wu,1,* Mi Yang,1,* Peng Zhao,1,2 Feng Zou,1 Jing Peng,1 Qiangting Deng,3 Guangyou Duan,4,* Hong Li1,* 1Department of Anesthesiology, Second Affiliated Hospital of Army Medical University, People’s Liberation Army of China ...
Wu Z, Yang M, Zhao P, Zou F, Peng J, Deng Q, Duan G, Li H   +7 more
doaj  

TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization

Protein & Cell, 2017
Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations are mainly sensory and vascular disorders such as pruritus and erythema.
O. Gouin, K. L'herondelle, N. Lebonvallet, C. Le Gall‐Ianotto, M. Sakka, V. Buhé, E. Plée-Gautier, J. Carré, L. Lefeuvre, L. Miséry, Raphaele Le Garrec   +10 more
semanticscholar   +1 more source

TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer’s disease

Aging Cell, 2020
Alzheimer's disease (AD) is one of the most common causes of neurodegenerative diseases in the elderly. The accumulation of amyloid‐β (Aβ) peptides is one of the pathological hallmarks of AD and leads to the impairments of synaptic plasticity and ...
Ye-hong Du, Min Fu, Zhilin Huang, Xin Tian, Junjie Li, Yayan Pang, Weihong Song, Yu Tian Wang, Zhifang Dong   +8 more
semanticscholar   +1 more source

A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1 [PDF]

Pain, 2008
Certain phosphorylation events are tightly controlled by scaffolding proteins such as A-kinase anchoring protein (AKAP). On nociceptive terminals, phosphorylation of transient receptor potential channel type 1 (TRPV1) results in the sensitization to many different stimuli, contributing to the development of hyperalgesia.
Nathaniel A, Jeske, Anibal, Diogenes, Nikita B, Ruparel, Jill C, Fehrenbacher, Michael, Henry, Armen N, Akopian, Kenneth M, Hargreaves   +6 more
openaire   +2 more sources