Results 71 to 80 of about 3,404 (180)
Natural Products from Mexican Medicinal Plants as Promising Trypanocidal Drugs
ChemistrySelect, Volume 10, Issue 37, October 6, 2025.Chagas disease (American Trypanosomiasis) is caused by the protozoan Trypanosoma cruzi. Worldwide it is one of the seventeen neglected tropical diseases. There is a need of new drugs. This review assesses the literature (2012‐2024) of secondary metabolites isolated from Mexican plants active against this parasite.
Karla Daniela Rodríguez‐Hernández +2 more
wiley +1 more source
Stress in dipteran insects mass‐reared for sterile insect technique applications
Insect Science, Volume 32, Issue 5, Page 1495-1523, October 2025.The connections between biotic and abiotic stress affecting mass‐reared dipteran insects and the associated stress and immunological responses. Numbers indicate the order in which the topics are discussed in this review. Abstract Stress may be viewed as the disturbance of homeostasis of an organism.
Caroline K. Mirieri +3 more
wiley +1 more source
Short-course eflornithine in Gambian trypanosomiasis: a multicentre randomized controlled trial
Bulletin of the World Health Organization, 2000 OBJECTIVE: A randomized controlled trial was conducted to determine whether 7 days of intravenous eflornithine (100 mg/kg every 6 h) was as effective as the standard 14-day regimen in the treatment of late-stage Trypanosoma brucei gambiense ...
Jacques Pépin +8 more
doaj
Future Journal of Pharmaceutical Sciences, 2021 Background The Chenopodium genus is a plant family widely spread worldwide that includes various plant species reputed to possess several medicinal virtues in folk medicines. Chenopodium ambrosioides L.
Félicien Mushagalusa Kasali +3 more
doaj +1 more source
A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin [PDF]
FEBS Letters, 1998 African trypanosomes contain a cytosolic serine oligopeptidase, called OP‐Tb, that is reversibly inhibited by the active principles of three of the five most commonly used trypanocidal drugs: pentamidine, diminazene and suramin. OP‐Tb was inhibited by pentamidine in a competitive manner, and by suramin in a partial, non‐competitive manner.
Morty, Rory E. +6 more
openaire +2 more sources
Improvement of colony management in insect mass‐rearing for sterile insect technique applications
Insect Science, Volume 32, Issue 5, Page 1476-1494, October 2025.Abstract Sterile Insect Technique (SIT) applications against major insect pests and disease vectors rely on the cost‐effective production of high‐quality sterile males. This largely depends on the optimal management of target pest colonies by maximizing the benefits provided by a genetically rich and pathogen‐free mother colony, the presence of ...
Adly M.M. Abd‐Alla +16 more
wiley +1 more source
Antiprotozoal Activity of Quinonemethide Triterpenes from Maytenus ilicifolia (Celastraceae)
Molecules, 2013 The present study describes the leishmanicidal and trypanocidal activities of two quinonemethide triterpenes, maytenin (1) and pristimerin (2), isolated from Maytenus ilicifolia root barks (Celastraceae).
Maysa Furlan +11 more
doaj +1 more source
Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves +3 more
wiley +1 more source
Different Derivatives of Plumbagin Analogue: Bioavailability and Their Toxicity Studies
Food Science &Nutrition, Volume 13, Issue 8, August 2025.Plumbagin, discovered in Plumbago zeylanica, has potential therapeutic effects such as anticancer, antimicrobial, and anti‐inflammatory characteristics. It has traditionally been used to treat anemia and rheumatic pain, but its therapeutic application is limited because of low bioavailability and toxicity risk factors.
Souparnika Thekkumkara +6 more
wiley +1 more source
Chemical Biology &Drug Design, Volume 105, Issue 4, April 2025.ABSTRACT Diketopiperazines (DKPs) have emerged as promising candidates for treating diverse diseases, particularly cancer. In this context, 2,5‐diketopiperazines have been extensively investigated in comparison with 2,6‐diketopiperazines. This work explores the selectivity and impact of 2,6‐diketopiperazine enantiomers derived from α‐amino acids on MDA‐
Flor Paulina Garrido González +4 more
wiley +1 more source