Results 41 to 50 of about 102,275 (301)

VSGs Expressed during Natural T. b. gambiense Infection Exhibit Extensive Sequence Divergence and a Subspecies-Specific Bias towards Type B N-Terminal Domains

mBio, 2022
Trypanosoma brucei gambiense is the primary causative agent of human African trypanosomiasis (HAT), a vector-borne disease endemic to West and Central Africa.
Jaime So, Sarah Sudlow, Abeer Sayeed, Tanner Grudda, Stijn Deborggraeve, Dieudonné Mumba Ngoyi, Didier Kashiama Desamber, Bill Wickstead, Veerle Lejon, Monica R. Mugnier   +9 more
doaj   +1 more source

Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

Nature Communications, 2019
The largest gene families in eukaryotes are subject to allelic exclusion, but mechanisms underpinning single allele selection and inheritance remain unclear.
Joana Faria, Lucy Glover, Sebastian Hutchinson, Cordula Boehm, Mark C. Field, D. Horn   +5 more
semanticscholar   +1 more source

TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei [PDF]

, 2014
The procyclic form of Trypanosoma brucei expresses procyclin surface glycoproteins with unusual glycosylphosphatidylinositol-anchor side chain structures that contain branched N-acetyllactosamine and lacto-N-biose units.
Acosta-Serrano, Alexander, Bakalara, Bangs, Ferguson, Guther, Guther, Hiroshi Nomoto, Ioffe, Izquierdo, Izquierdo, Kazunori Hashida, Kelley, Kobata, Mami Hino, Masayuki Nakanishi, Mehlert, Mehlert, Mehlert, Mehlert, Michael A.J. Ferguson, Moe Karasudani, Nagamune, Nolan, Oguri, Parussini, Pierleoni, Roper, Schiller, Schwartz, Stanley, Strang, Takahiro Shiraishi, Treumann, Vassella, Wirtz, Zamze   +36 more
core   +2 more sources

Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei Strains

Molecules, 2019
New anti-infective agents are urgently needed to fight microbial resistance. Methicillin-resistant Staphylococcus aureus (MRSA) strains are particularly responsible for complicated pathologies that are difficult to treat due to their virulence and the ...
L. Bocquet, S. Sahpaz, N. Bonneau, C. Beaufay, S. Mahieux, J. Samaillie, V. Roumy, J. Jacquin, S. Bordage, T. Hennebelle, F. Chai, J. Quetin-Leclercq, C. Neut, C. Rivière   +13 more
semanticscholar   +1 more source

Characterization of an endopeptidase of Trypanosoma brucei brucei

Archives of Biochemistry and Biophysics, 1992
A soluble 80-kDa endopeptidase has been isolated from Trypanosoma brucei brucei. The enzyme, which has a pI 5.1, is optimally active at about pH 8.2 and has apparent pKa values of 6.0 and greater than or equal to 10. It is inhibited by the serine protease inhibitor diisopropylfluorophosphate and by the serine protease mechanism-based inhibitor 3,4 ...
Kornblatt, M.J., Mpimbaza, G.W.N., Lonsdale-Eccles, J.D.   +2 more
openaire   +4 more sources

Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake [PDF]

, 2013
It has long been established that the Trypanosoma brucei TbAT1/P2 aminopurine transporter is involved in the uptake of diamidine and arsenical drugs including pentamidine, diminazene aceturate and melarsoprol.
Al-Salabi, Barrett, Biebinger, Bray, Bridges, Burchmore, Burkard, Carter, Carter, Carter, Chitanga, Collar, Damper, De Koning, De Koning, De Koning, De Koning, De Koning, De Koning, De Koning, Delespaux, Delespaux, Delespaux, Delespaux, Eisler, Fulton, Geerts, Girgis-Takla, Gould, Hawking, Henriques, Hirumi, Lourie, Mamoudou, Matovu, Matovu, Moti, Mäser, Natto, Räz, Sanchez, Sanchez, Sanchez, Spoerri, Tamura, Teka, Wallace, Witola   +47 more
core   +1 more source

Population genetics of Trypanosoma brucei circulating in Glossina palpalis palpalis and domestic animals of the Fontem sleeping sickness focus of Cameroon

Parasites & Vectors, 2014
Background Human African Trypanosomiasis is still a public health threat in Cameroon. To assess Trypanosoma brucei strains circulating in the Fontem sleeping sickness focus, we conducted a genetic structure study using microsatellites to assess genotypes
Gustave Simo, Guy Roger Njitchouang, Tresor Tito Tanekou Melachio, Flobert Njiokou, Gerard Cuny, Asonganyi Tazoacha   +5 more
doaj   +1 more source

A gene expression comparison of Trypanosoma brucei and Trypanosoma congolense in the bloodstream of the mammalian host reveals species-specific adaptations to density-dependent development

PLoS Neglected Tropical Diseases, 2018
In the bloodstream of mammalian hosts Trypanosoma brucei undergoes well-characterised density-dependent growth control and developmental adaptation for transmission. This involves the differentiation from proliferative, morphologically ‘slender’ forms to
Eleanor Silvester, A. Ivens, K. Matthews
semanticscholar   +1 more source

Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline, and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives was designed, synthesised, and evaluated in vitro against three ...
Jean Guillon, Anita Cohen, Clotilde Boudot, Alessandra Valle, Vittoria Milano, Rabindra Nath Das, Aurore Guédin, Stéphane Moreau, Luisa Ronga, Solène Savrimoutou, Maxime Demourgues, Elodie Reviriego, Sandra Rubio, Sandie Ferriez, Patrice Agnamey, Cécile Pauc, Serge Moukha, Pascale Dozolme, Sophie Da Nascimento, Pierre Laumaillé, Anne Bouchut, Nadine Azas, Jean-Louis Mergny, Catherine Mullié, Pascal Sonnet, Bertrand Courtioux   +25 more
doaj   +1 more source

Anti-trypanosomal activity and DNA fingerprinting of fifteen Euphorbia species using ISSR and SCoT markers

Beni-Suef University Journal of Basic and Applied Sciences, 2021
Background Euphorbia is the largest genus in family Euphorbiaceae with a great biological and genetic diversity. The anti-trypanosomal activity of the crude extract of 15 Euphorbia species against Trypanosoma brucei brucei was carried out.
Seham S. El-Hawary, Nadia M. Lithy, Elham Amin, Sameh F. AbouZid, Rabab Mohammed   +4 more
doaj   +1 more source