Results 51 to 60 of about 22,113 (163)

Glycosomal Phosphoenolpyruvate Carboxykinase CRISPR/Cas9‐Deletion and Its Role in Trypanosoma cruzi Metacyclogenesis and Infectivity in Mammalian Host

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Effects of PEPCK deficiency in Trypanosoma cruzi bioenergetics and life stages. ABSTRACT Trypanosoma cruzi, the causative agent of Chagas disease, possesses glycosomes—unique organelles that house key metabolic enzymes, several of which are promising therapeutic targets.
Carolina S. D. Vieira, Wei Wang, Fernando Sanchez‐Valdez, Jihyun Lim, Brooke E. White, Camilla G. S. Souza, Rick L. Tarleton, Marcia C. Paes, Natalia P. A. Nogueira   +8 more
wiley   +1 more source

Edelfosine (ET-18-OCH3) a Promising Alkylphospholipid against Resistant Trichomonas vaginalis

Proceedings, 2017
Edelfosine (ET-18-OCH3) is an alkylphospholipid with an analogous structure to miltefosine. Both molecules are active against kinetoplastids (Leishmania spp., Trypanosoma cruzi and Trypanosoma brucei). [...]
Alexandra Ibáñez-Escribano, Jose Antonio Escario, Faustino Mollinedo, Alicia Gómez-Barrio   +3 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, Volume 600, Issue 5, Page 591-611, March 2026.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Réponse du poulet nigérian local ( Gallus domesticus) aux trypanosomes

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1988
La réponse du poulet nigérian local aux souches de Trypanosoma brucei 8/18 et T. vivax Y58 a été recherchée. Le poulet local utilisé dans cette étude était sensible à T. brucei mais réfractaire à T. vivax (Y58) (une souche adaptée aux rongeurs).
O.A. Dina, R.O.A. Arowolo
doaj   +1 more source

Equine trypanosomiasis, a systematic review: Disease management

Equine Veterinary Journal, Volume 58, Issue 2, Page 320-332, March 2026.
Abstract Background Equine trypanosomiasis is a neglected protozoal disease. Objectives To answer the study question: In equines what are the effects of disease management of trypanosomiasis on disease severity (individual level) and disease prevalence (population level) compared to no intervention? Study Design Systematic review.
Alexandra G. Raftery, Lauren Gummery, Karelhia Garcia, Dinesh Mohite, Paul Capewell, David Sutton   +5 more
wiley   +1 more source

Association between IL1 gene polymorphism and human African trypanosomiasis in populations of sleeping sickness foci of southern Cameroon. [PDF]

PLoS Neglected Tropical Diseases, 2019
BACKGROUND:Human African Trypanosomiasis (HAT) is a neglected tropical disease caused by infections due to Trypanosoma brucei subspecies. In addition to the well-established environmental and behavioural risks of becoming infected, there is evidence for ...
Elvis Ofon, Harry Noyes, Vincent Ebo'o Eyanga, Flobert Njiokou, Mathurin Koffi, Pythagore Fogue, Christiane Hertz-Fowler, Annette MacLeod, Enock Matovu, Gustave Simo, TrypanoGEN Research Group, as members of The H3Africa Consortium   +10 more
doaj   +1 more source

Stunning Intricacies of RNA Editing Complexes RECC, RESC, and REH2C: Functional Organization, Developmental Regulation, and Evolutionary History in Kinetoplastid Protists

WIREs RNA, Volume 17, Issue 2, March/April 2026.
U‐indel RNA editing targets mRNA:gRNA duplexes through three key complexes that collectively govern assembly, specificity, catalysis, and developmental regulation. Modern tools, including artificial intelligence, analyze the organization, dynamics, and evolution of the remarkable holo‐editosome, opening new avenues in RNA biology and therapy.
Suzanne M. McDermott, Julius Lukeš, Laurie K. Read, Reza Salavati, Achim Schnaufer, Sara L. Zimmer, Jason Carnes, Alasdair Ivens, Naghmeh Poorinmohammad, Nicholas J. Savill, Dave Speijer, Ken Stuart, Kristína Záhonová, Poorya Mirzavand Borujeni, Zihao Chen, Cody Goode, Sunil Kumar Sharma, Lars O’Hara, Jorge Cruz‐Reyes   +18 more
wiley   +1 more source

C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. [PDF]

PLoS Pathogens, 2009
Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T.
Laurence Lecordier, Benoit Vanhollebeke, Philippe Poelvoorde, Patricia Tebabi, Françoise Paturiaux-Hanocq, Fabienne Andris, Laurence Lins, Etienne Pays   +7 more
doaj   +1 more source

Equine trypanosomiasis, a systematic review and meta‐analyses: Prevalence, morbidity and mortality

Equine Veterinary Journal, Volume 58, Issue 2, Page 291-319, March 2026.
Abstract Background Equine trypanosomiasis is a neglected protozoal disease. Objectives To perform a systematic search of literature to explore: (1) In equines what is the global geographical distribution and prevalence of trypanosomiasis? In low and middle‐income countries (LMICs) is trypanosomiasis more prevalent than in higher‐income countries (HICs)
Alexandra G. Raftery, Lauren Gummery, Karelhia Garcia, Dinesh Mohite, Paul Capewell, David G. M. Sutton   +5 more
wiley   +1 more source

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign.

PLoS Neglected Tropical Diseases, 2012
Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Drugs available for the treatment of HAT have significant issues related to difficult administration regimes ...
Melissa L Sykes, Jonathan B Baell, Marcel Kaiser, Eric Chatelain, Sarah R Moawad, Danny Ganame, Jean-Robert Ioset, Vicky M Avery   +7 more
doaj   +1 more source