Results 51 to 60 of about 102,275 (301)

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector

PLoS Pathogens, 2017
Adaptation to different nutritional environments is essential for life cycle completion by all Trypanosoma brucei sub-species. In the tsetse fly vector, L-proline is among the most abundant amino acids and is mainly used by the fly for lactation and to ...
Brian S. Mantilla, Letícia Marchese, Aitor Casas-Sánchez, N. Dyer, Nicholas Ejeh, M. Biran, F. Bringaud, M. Lehane, Á. Acosta-Serrano, A. Silber   +9 more
semanticscholar   +1 more source

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

International Journal for Parasitology: Drugs and Drug Resistance, 2015
Aquaglyceroporin-2 is a known determinant of melarsoprol–pentamidine cross-resistance in Trypanosoma brucei brucei laboratory strains. Recently, chimerization at the AQP2–AQP3 tandem locus was described from melarsoprol–pentamidine cross-resistant ...
Fabrice E. Graf, Nicola Baker, Jane C. Munday, Harry P. de Koning, David Horn, Pascal Mäser   +5 more
doaj   +1 more source

Trypanosoma brucei: meet the system [PDF]

Current Opinion in Microbiology, 2014
African trypanosomes cause devastating diseases in humans and domestic animals. The parasites evolved early in the eukaryotic lineage and have numerous biochemical peculiarities that distinguish them from other systems. These include unconventional mechanisms for expressing nuclear and mitochondrial genes as well as unusual subcellular localizations ...
Fiona Achcar, Michael P. Barrett, Eduard J. Kerkhoven   +2 more
openaire   +3 more sources

Molecular mechanisms underlying the control of antigenic variation in African trypanosomes [PDF]

, 2010
African trypanosomes escape the host adaptive immune response by switching their dense protective coat of Variant Surface Glycoprotein (VSG). Each cell expresses only one VSG gene at a time from a telomeric expression site (ES).
Alsford, Alsford, Barry, Boboila, Boothroyd, Burton, Cesare, Conway, David Horn, Dreesen, Ekwall, Field, Figueiredo, Figueiredo, Glover, Glover, Glover, Gottschling, Grunstein, Halme, Hartley, Hastings, Hertz-Fowler, Horn, Horn, Huertas, Hughes, Kawahara, Kristjuhan, Landeira, Lehmann, Lydeard, Marcello, McCulloch, McCulloch, McEachern, McVey, Morrison, Navarro, Proudfoot, Richard McCulloch, Robinson, San Filippo, Schwede, Simsek, Stanne, Sutherland, Tan, Vanhamme, Wang, Yang, Zhang, Zhou   +52 more
core   +3 more sources

The Dermis as a Delivery Site of Trypanosoma brucei for Tsetse Flies

PLoS Pathogens, 2016
Tsetse flies are the sole vectors of Trypanosoma brucei parasites that cause sleeping sickness. Our knowledge on the early interface between the infective metacyclic forms and the mammalian host skin is currently highly limited.
G. Caljon, Nick Van Reet, C. De Trez, M. Vermeersch, D. Perez-Morga, J. Van Den Abbeele   +5 more
semanticscholar   +1 more source

The Trypanosoma brucei AIR9-like protein is cytoskeleton-associated and is required for nucleus positioning and accurate cleavage furrow placement [PDF]

, 2012
AIR9 is a cytoskeleton-associated protein in Arabidopsis thaliana with roles in cytokinesis and cross wall maturation, and reported homologues in land plants and excavate protists, including trypanosomatids.
Almeida Costa, Cristina, Gibson, Wendy, Hammarton, Tansy, May, Sophie, Peacock, Lori, Robinson, Derrick, Robinson, Derrick R, Tetley, Laurence   +7 more
core   +2 more sources

Exosome secretion affects social motility in Trypanosoma brucei

PLoS Pathogens, 2017
Extracellular vesicles (EV) secreted by pathogens function in a variety of biological processes. Here, we demonstrate that in the protozoan parasite Trypanosoma brucei, exosome secretion is induced by stress that affects trans-splicing.
D. Eliaz, S. Kannan, Hadassa Shaked, Gil Arvatz, Itai Dov Tkacz, L. Binder, H. Waldman Ben-Asher, Uthman Okalang, Vaibhav Chikne, Smadar Cohen-Chalamish, S. Michaeli   +10 more
semanticscholar   +1 more source

Measure of Molecular Diversity within the Trypanosoma brucei Subspecies Trypanosoma brucei brucei and Trypanosoma brucei gambiense as Revealed by Genotypic Characterization

Experimental Parasitology, 2001
We have evaluated whether sequence polymorphisms in the rRNA intergenic spacer region can be used to study the relatedness of two subspecies of Trypanosoma brucei. Thirteen T. brucei isolates made up of 6 T. b. brucei and 7 T. b. gambiense were analyzed using restriction fragment length polymorphism (RFLP).
Agbo, E.C., Majiwa, P.A.O., Classsen, E.J.H.M., Roos, M.H.   +3 more
openaire   +4 more sources

Activation of endocytosis as an adaptation to the mammalian host by trypanosomes [PDF]

, 2007
Immune evasion in African trypanosomes is principally mediated by antigenic variation, but rapid internalization of surface-bound immune factors may contribute to survival.
Field, Mark C, Gibson, Wendy, Matthews, Keith, Natesan, Senthil Kumar A, Peacock, Lori   +4 more
core   +2 more sources

Molecular variation of Trypanosoma brucei subspecies as revealed by AFLP fingerprinting [PDF]

, 2002
Genetic analysis of Trypanosoma spp. depends on the detection of variation between strains. We have used the amplified fragment length polymorphism (AFLP) technique to develop a convenient and reliable method for genetic characterization of Trypanosome ...
Agbo, E.E.C., Claassen, H.J.H.M., Majiwa, P.A.O., Pas, M.F.W., te   +3 more
core   +9 more sources