Results 1 to 10 of about 18,366 (207)

Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria [PDF]

Parasites & Vectors, 2019
Background Animal trypanosomosis is endemic in Nigeria, while the human disease caused by Trypanosoma brucei gambiense is rarely reported nowadays after efforts to bring it under control in the 20th century.
Paschal Ugochukwu Umeakuana, Wendy Gibson, Romanus Chukwuduruo Ezeokonkwo, Boniface Maduka Anene   +3 more
doaj   +9 more sources

Target product profile: <i>Trypanosoma brucei gambiense</i> test to verify elimination. [PDF]

Bull World Health Organ, 2023
Human African trypanosomiasis is a life-threatening parasitic infection transmitted by the tsetse fly in sub-Saharan Africa. The most common form is caused by Trypanosoma brucei gambiense, with humans as the main reservoir.
Priotto G, Franco JR, Lejon V, Büscher P, Matovu E, Ndung'u J, Biéler S, Mumba D, Van Reet N, Verlé P, Jamonneau V, Simarro PP, Ebeja AK, Sankara D, Dagne DA.   +14 more
europepmc   +5 more sources

Evidence of the absence of human African trypanosomiasis in two northern districts of Uganda: Analyses of cattle, pigs and tsetse flies for the presence of Trypanosoma brucei gambiense. [PDF]

PLoS Neglected Tropical Diseases, 2020
BACKGROUND:Large-scale control of sleeping sickness has led to a decline in the number of cases of Gambian human African trypanosomiasis (g-HAT) to
Lucas J Cunningham, Jessica K Lingley, Iñaki Tirados, Johan Esterhuizen, Mercy Opiyo, Clement T N Mangwiro, Mike J Lehane, Stephen J Torr   +7 more
doaj   +5 more sources

Neural Damage in Experimental Trypanosoma brucei gambiense Infection: The Suprachiasmatic Nucleus [PDF]

Frontiers in Neuroanatomy, 2018
Trypanosoma brucei (T. b.) gambiense is the parasite subspecies responsible for most reported cases of human African trypanosomiasis (HAT) or sleeping sickness.
Chiara Tesoriero, Yuan-Zhong Xu, Dieudonné Mumba Ngoyi, Marina Bentivoglio, Marina Bentivoglio   +4 more
doaj   +7 more sources

Target product profile: diagnostic test for <i>Trypanosoma brucei gambiense</i>. [PDF]

Bull World Health Organ, 2023
Human African trypanosomiasis is a life-threatening parasitic infection endemic to sub-Saharan Africa. Around 95% of cases are due to Trypanosoma brucei gambiense, found in western and central Africa.
Priotto G, Franco JR, Lejon V, Büscher P, Matovu E, Ndung'u J, Biéler S, Mumba D, Van Reet N, Verlé P, Jamonneau V, Simarro PP, Ebeja AK, Sankara D, Dagne DA.   +14 more
europepmc   +4 more sources

Deep kinetoplast genome analyses result in a novel molecular assay for detecting Trypanosoma brucei gambiense-specific minicircles. [PDF]

NAR Genom Bioinform, 2022
The World Health Organization targeted Trypanosoma brucei gambiense (Tbg) human African trypanosomiasis for elimination of transmission by 2030. Sensitive molecular markers that specifically detect Tbg type 1 (Tbg1) parasites will be important tools to ...
Geerts M, Chen Z, Bebronne N, Savill NJ, Schnaufer A, Büscher P, Van Reet N, Van den Broeck F.   +7 more
europepmc   +4 more sources

Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense [PDF]

Nature Communications, 2022
Decreased functionality and expression of trypanosome haptoglobin-hemoglobin receptor (HpHbR) is one of the evolutionary modifications that have allowed Trypanosoma brucei gambiense to infect humans. Here, Horakova et al.
Eva Horáková, Laurence Lecordier, Paula Cunha, Roman Sobotka, Piya Changmai, Catharina J. M. Langedijk, Jan Van Den Abbeele, Benoit Vanhollebeke, Julius Lukeš   +8 more
doaj   +3 more sources

Two-Year Follow-Up of Trypanosoma brucei gambiense Serology after Successful Treatment of Human African Trypanosomiasis: Results of Four Different Sero-Diagnostic Tests [PDF]

Diagnostics, 2022
Gambiense human African trypanosomiasis (gHAT), also known as gambiense sleeping sickness, is a parasitic infection caused by Trypanosoma brucei gambiense. During the last decades, gHAT incidence has been brought to an all-time low.
Raquel Inocencio da Luz, Sara Tablado Alonso, Philippe Büscher, Paul Verlé, Anja De Weggheleire, Dieudonné Mumba Ngoyi, Pati Patient Pyana, Epco Hasker   +7 more
doaj   +3 more sources

Target product profile: <i>Trypanosoma brucei gambiense</i> test for low-prevalence settings. [PDF]

Bull World Health Organ, 2023
Having caused devastating epidemics during the 20th century, the incidence of life-threatening human African trypanosomiasis has fallen to historically low levels as a result of sustained and coordinated efforts over the past 20 years.
Priotto G, Franco JR, Lejon V, Büscher P, Matovu E, Ndung'u J, Biéler S, Mumba D, Van Reet N, Verlé P, Jamonneau V, Simarro PP, Ebeja AK, Sankara D, Dagne DA.   +14 more
europepmc   +4 more sources

A pilot study demonstrating the identification of Trypanosoma brucei gambiense and T. b. rhodesiense in vectors using a multiplexed high-resolution melt qPCR. [PDF]

PLoS Negl Trop Dis, 2020
Human African Trypanosomiasis (HAT) is a potentially fatal parasitic infection caused by the trypanosome sub-species Trypanosoma brucei gambiense and T. b. rhodesiense transmitted by tsetse flies. Currently, global HAT case numbers are reaching less than
Garrod G, Adams ER, Lingley JK, Saldanha I, Torr SJ, Cunningham LJ.   +5 more
europepmc   +4 more sources