Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria [PDF]
Parasites & Vectors, 2019 Background Animal trypanosomosis is endemic in Nigeria, while the human disease caused by Trypanosoma brucei gambiense is rarely reported nowadays after efforts to bring it under control in the 20th century.
Paschal Ugochukwu Umeakuana +3 more
doaj +9 more sources
Neural Damage in Experimental Trypanosoma brucei gambiense Infection: The Suprachiasmatic Nucleus [PDF]
Frontiers in Neuroanatomy, 2018 Trypanosoma brucei (T. b.) gambiense is the parasite subspecies responsible for most reported cases of human African trypanosomiasis (HAT) or sleeping sickness.
Chiara Tesoriero +4 more
doaj +7 more sources
Target product profile: diagnostic test for <i>Trypanosoma brucei gambiense</i>. [PDF]
Bull World Health Organ, 2023 Human African trypanosomiasis is a life-threatening parasitic infection endemic to sub-Saharan Africa. Around 95% of cases are due to Trypanosoma brucei gambiense, found in western and central Africa.
Priotto G +14 more
europepmc +4 more sources
Trypanosoma brucei gambiense group 2 experimental in vivo life cycle: from procyclic to bloodstream form. [PDF]
Parasite, 2023 Trypanosoma brucei gambiense (Tbg) group 2 is a subgroup of trypanosomes able to infect humans in West and Central Africa. Unlike other agents causing sleeping sickness such as Tbg group 1 and Trypanosoma brucei rhodesiense, Tbg2 lacks the typical ...
Juban P +4 more
europepmc +4 more sources
Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense [PDF]
Nature Communications, 2022 Decreased functionality and expression of trypanosome haptoglobin-hemoglobin receptor (HpHbR) is one of the evolutionary modifications that have allowed Trypanosoma brucei gambiense to infect humans. Here, Horakova et al.
Eva Horáková +8 more
doaj +3 more sources
Two-Year Follow-Up of Trypanosoma brucei gambiense Serology after Successful Treatment of Human African Trypanosomiasis: Results of Four Different Sero-Diagnostic Tests [PDF]
Diagnostics, 2022 Gambiense human African trypanosomiasis (gHAT), also known as gambiense sleeping sickness, is a parasitic infection caused by Trypanosoma brucei gambiense. During the last decades, gHAT incidence has been brought to an all-time low.
Raquel Inocencio da Luz +7 more
doaj +3 more sources
Target product profile: <i>Trypanosoma brucei gambiense</i> test to verify elimination. [PDF]
Bull World Health Organ, 2023 Human African trypanosomiasis is a life-threatening parasitic infection transmitted by the tsetse fly in sub-Saharan Africa. The most common form is caused by Trypanosoma brucei gambiense, with humans as the main reservoir.
Priotto G +14 more
europepmc +4 more sources
Trypanosoma brucei gambiense-iELISA: A Promising New Test for the Post-Elimination Monitoring of Human African Trypanosomiasis. [PDF]
Clin Infect Dis, 2021 Background The World Health Organization targeted Trypanosoma brucei gambiense human African trypanosomiasis (gHAT) for elimination as a public health problem and for elimination of transmission. To measure gHAT elimination success with prevalences close
Geerts M +7 more
europepmc +4 more sources
Evidence of the absence of human African trypanosomiasis in two northern districts of Uganda: Analyses of cattle, pigs and tsetse flies for the presence of Trypanosoma brucei gambiense. [PDF]
PLoS Neglected Tropical Diseases, 2020 BACKGROUND:Large-scale control of sleeping sickness has led to a decline in the number of cases of Gambian human African trypanosomiasis (g-HAT) to
Lucas J Cunningham +7 more
doaj +3 more sources
Prospective evaluation of a rapid diagnostic test for Trypanosoma brucei gambiense infection developed using recombinant antigens. [PDF]
PLoS Negl Trop Dis, 2018 Background Diagnosis and treatment are central elements of strategies to control Trypanosoma brucei gambiense human African trypanosomiasis (HAT). Serological screening is a key entry point in diagnostic algorithms.
Lumbala C +5 more
europepmc +4 more sources