Spatially and genetically distinct African trypanosome virulence variants defined by host interferon-g response [PDF]
We describe 2 spatially distinct foci of human African trypansomiasis in eastern Uganda. The Tororo and Soroti foci of <i>Trypanosoma brucei rhodesiense</i> infection were genetically distinct as characterized by 6 microsatellite and 1 ...
Anneli Cooper+19 more
core +1 more source
Bioactive peptides (BAPs) obtained from plants and microbes have been thoroughly explored and studied due to their prophylactic properties. The use of BAPs seems to be a promising substitute for several currently available antibiotics because of their antimicrobial properties against foodborne pathogens.
Anowar Khasru Parvez+9 more
wiley +1 more source
Restriction of the alternative pathway of human complement by intact Trypanosoma brucei subsp. gambiense. [PDF]
Dana V. Devine+2 more
openalex +3 more sources
Discovery of mating in the major African livestock pathogen Trypanosoma congolense [PDF]
The protozoan parasite, Trypanosoma congolense, is one of the most economically important pathogens of livestock in Africa and, through its impact on cattle health and productivity, has a significant effect on human health and well being.
A MacLeod+63 more
core +3 more sources
Human African Trypanosomiasis Transmission, Kinshasa, Democratic Republic of Congo
To investigate the epidemiology of human African trypanosomiasis (sleeping sickness) in Kinshasa, Democratic Republic of Congo, 2 entomologic surveys were conducted in 2005.
Gustave Simo+7 more
doaj +1 more source
The use of Multiple Displacement Amplification to increase the detection and genotyping of Trypanosoma samples immobilised on FTA filters. [PDF]
Whole genome amplification methods are a recently developed tool for amplifying DNA from limited template. We report its application in trypanosome infections, characterized by low parasitemias.
Likeufack, A.C.L.+7 more
core
Eflornithine is Safer Than Melarsoprol for the Treatment of Second-Stage Trypanosoma Brucei Gambiense Human African Trypanosomiasis. [PDF]
Patients with second-stage human African trypanosomiasis treated with eflornithine (n = 251) in 2003 in Kiri, southern Sudan, had an adjusted relative risk of death of 0.2 and experienced significantly fewer cutaneous and neurological adverse effects ...
A. Meussen+10 more
core +2 more sources
Background In a mammalian host, the cell surface of African trypanosomes is protected by a monolayer of a single variant surface glycoprotein (VSG). The VSG is central to antigenic variation; one VSG gene is expressed at any one time and there is a low ...
Sharma Reuben+6 more
doaj +1 more source
Epidemiology of human African trypanosomiasis
Jose R Franco,1 Pere P Simarro,1 Abdoulaye Diarra,2 Jean G Jannin1 1World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland; 2World Health Organization, Inter Country Support ...
Franco JR+3 more
doaj
Target product profile: diagnostic test for Trypanosoma brucei gambiense. [PDF]
Priotto G+14 more
europepmc +1 more source