Results 11 to 20 of about 18,054 (201)

Is the elimination of 'sleeping sickness' affordable? Who will pay the price? Assessing the financial burden for the elimination of human African trypanosomiasis Trypanosoma brucei gambiense in sub-Saharan Africa. [PDF]

BMJ Glob Health, 2019
Introduction Programme to eliminate neglected tropical diseases (NTDs) have gained global recognition, and may allow for improvements to universal health coverage and poverty alleviation. It is hoped that elimination of human African trypanosomiasis (HAT)
Sutherland CS, Tediosi F.
europepmc   +4 more sources

Unusual MRI Findings in African Trypanosoma brucei gambiense Trypanosomiasis: Dentate Nuclei and Hypothalamic Lesions. [PDF]

Am J Trop Med Hyg, 2020
Monique Boukobza,* Sylvie Lariven, Sandrine Houzé, and Jean-Pierre Laissy Department of Radiology, Assistance Publique-Hôpitaux de Paris, Bichat University Hospital, Paris, France; Infectious and Tropical Diseases Department, Assistance Publique-Hôpitaux
Boukobza M, Lariven S, Houzé S, Laissy JP.   +3 more
europepmc   +4 more sources

The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of Côte d'Ivoire identifies pigs and cattle as potential reservoirs of Trypanosoma brucei gambiense. [PDF]

PLoS Neglected Tropical Diseases, 2017
BACKGROUND:Important control efforts have led to a significant reduction of the prevalence of human African trypanosomiasis (HAT) in Côte d'Ivoire, but the disease is still present in several foci.
Martial Kassi N'Djetchi, Hamidou Ilboudo, Mathurin Koffi, Jacques Kaboré, Justin Windingoudi Kaboré, Dramane Kaba, Fabrice Courtin, Bamoro Coulibaly, Pierre Fauret, Lingué Kouakou, Sophie Ravel, Stijn Deborggraeve, Philippe Solano, Thierry De Meeûs, Bruno Bucheton, Vincent Jamonneau   +15 more
doaj   +3 more sources

Trypanosoma brucei gambiense Infections in Mice Lead to Tropism to the Reproductive Organs, and Horizontal and Vertical Transmission. [PDF]

PLoS Negl Trop Dis, 2016
Trypanosoma brucei gambiense, transmitted by the tsetse fly, is the main causative agent of Human African trypanosomosis in West Africa and poses a significant health risk to 70 million people.
Biteau N, Asencio C, Izotte J, Rousseau B, Fèvre M, Pillay D, Baltz T.   +6 more
europepmc   +4 more sources

Target product profile: <i>Trypanosoma brucei gambiense</i> test for low-prevalence settings. [PDF]

Bull World Health Organ, 2023
Having caused devastating epidemics during the 20th century, the incidence of life-threatening human African trypanosomiasis has fallen to historically low levels as a result of sustained and coordinated efforts over the past 20 years.
Priotto G, Franco JR, Lejon V, Büscher P, Matovu E, Ndung'u J, Biéler S, Mumba D, Van Reet N, Verlé P, Jamonneau V, Simarro PP, Ebeja AK, Sankara D, Dagne DA.   +14 more
europepmc   +2 more sources

Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. [PDF]

Nat Commun, 2023
African Trypanosomes have developed elaborate immune evasion mechanisms. Here, the authors present the cryoelectron microscopy structures of a trypanosome surface receptor with human complement C3 and C3b, revealing several modes of complement ...
Sülzen H, Began J, Dhillon A, Kereïche S, Pompach P, Votrubova J, Zahedifard F, Šubrtova A, Šafner M, Hubalek M, Thompson M, Zoltner M, Zoll S.   +12 more
europepmc   +2 more sources

Modelling host- Trypanosoma brucei gambiense interactions in vitro using human induced pluripotent stem cell-derived cortical brain organoids. [PDF]

F1000Res, 2023
Background: Sleeping sickness is caused by the extracellular parasite Trypanosoma brucei and is associated with neuroinflammation and neuropsychiatric disorders, including disruption of sleep/wake patterns, and is now recognised as a circadian disorder ...
Chandrasegaran P, Nabilla Lestari A, Sinton MC, Gopalakrishnan J, Quintana JF.   +4 more
europepmc   +2 more sources

The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense. [PDF]

PLoS Pathogens, 2013
Trypanosoma brucei gambiense causes 97% of all cases of African sleeping sickness, a fatal disease of sub-Saharan Africa. Most species of trypanosome, such as T. b.
Paul Capewell, Caroline Clucas, Eric DeJesus, Rudo Kieft, Stephen Hajduk, Nicola Veitch, Pieter C Steketee, Anneli Cooper, William Weir, Annette MacLeod   +9 more
doaj   +8 more sources

Deep kinetoplast genome analyses result in a novel molecular assay for detecting Trypanosoma brucei gambiense-specific minicircles. [PDF]

NAR Genom Bioinform, 2022
The World Health Organization targeted Trypanosoma brucei gambiense (Tbg) human African trypanosomiasis for elimination of transmission by 2030. Sensitive molecular markers that specifically detect Tbg type 1 (Tbg1) parasites will be important tools to ...
Geerts M, Chen Z, Bebronne N, Savill NJ, Schnaufer A, Büscher P, Van Reet N, Van den Broeck F.   +7 more
europepmc   +2 more sources

Experimental evidence that immune trypanolysis using the LiTat 1.3 and LiTat 1.5 variant antigen types is not specific to Trypanosoma brucei gambiense in pigs. [PDF]

Parasite, 2022
In the context of the human African trypanosomiasis elimination process, reliable and accurate diagnostic tools are crucial for exploring the role of a potential animal reservoir of Trypanosoma brucei gambiense.
Ilboudo K, Hounyeme RE, Kabore J, Boulangé A, Gimonneau G, Salou E, Belem AGM, Lejon V, Compaoré CFA, Bucheton B, Koffi M, Solano P, Berthier D, Thevenon S, Jamonneau V.   +14 more
europepmc   +2 more sources