Results 11 to 20 of about 18,366 (207)

Evaluation of two candidate molecules-TCTP and cecropin-on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis. [PDF]

Insect Sci
Trypanosomiasis, transmitted by tsetse flies (Glossina spp.), poses a significant health threat in 36 sub‐Saharan African countries. Current control methods targeting tsetse flies, while effective, allow reinfestation.
Ngambia Freitas FS, De Vooght L, Njiokou F, Abeele JVD, Bossard G, Tchicaya B, Corrales RM, Ravel S, Geiger A, Berthier-Teyssedre D.   +9 more
europepmc   +5 more sources

Is the elimination of 'sleeping sickness' affordable? Who will pay the price? Assessing the financial burden for the elimination of human African trypanosomiasis Trypanosoma brucei gambiense in sub-Saharan Africa. [PDF]

BMJ Glob Health, 2019
Introduction Programme to eliminate neglected tropical diseases (NTDs) have gained global recognition, and may allow for improvements to universal health coverage and poverty alleviation. It is hoped that elimination of human African trypanosomiasis (HAT)
Sutherland CS, Tediosi F.
europepmc   +4 more sources

The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of Côte d'Ivoire identifies pigs and cattle as potential reservoirs of Trypanosoma brucei gambiense. [PDF]

PLoS Neglected Tropical Diseases, 2017
BACKGROUND:Important control efforts have led to a significant reduction of the prevalence of human African trypanosomiasis (HAT) in Côte d'Ivoire, but the disease is still present in several foci.
Martial Kassi N'Djetchi, Hamidou Ilboudo, Mathurin Koffi, Jacques Kaboré, Justin Windingoudi Kaboré, Dramane Kaba, Fabrice Courtin, Bamoro Coulibaly, Pierre Fauret, Lingué Kouakou, Sophie Ravel, Stijn Deborggraeve, Philippe Solano, Thierry De Meeûs, Bruno Bucheton, Vincent Jamonneau   +15 more
doaj   +3 more sources

Trypanosoma brucei gambiense group 2 experimental in vivo life cycle: from procyclic to bloodstream form. [PDF]

Parasite, 2023
Trypanosoma brucei gambiense (Tbg) group 2 is a subgroup of trypanosomes able to infect humans in West and Central Africa. Unlike other agents causing sleeping sickness such as Tbg group 1 and Trypanosoma brucei rhodesiense, Tbg2 lacks the typical ...
Juban P, Bart JM, Ségard A, Jamonneau V, Ravel S.   +4 more
europepmc   +2 more sources

Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. [PDF]

Nat Commun, 2023
African Trypanosomes have developed elaborate immune evasion mechanisms. Here, the authors present the cryoelectron microscopy structures of a trypanosome surface receptor with human complement C3 and C3b, revealing several modes of complement ...
Sülzen H, Began J, Dhillon A, Kereïche S, Pompach P, Votrubova J, Zahedifard F, Šubrtova A, Šafner M, Hubalek M, Thompson M, Zoltner M, Zoll S.   +12 more
europepmc   +2 more sources

Modelling host- Trypanosoma brucei gambiense interactions in vitro using human induced pluripotent stem cell-derived cortical brain organoids. [PDF]

F1000Res, 2023
Background: Sleeping sickness is caused by the extracellular parasite Trypanosoma brucei and is associated with neuroinflammation and neuropsychiatric disorders, including disruption of sleep/wake patterns, and is now recognised as a circadian disorder ...
Chandrasegaran P, Nabilla Lestari A, Sinton MC, Gopalakrishnan J, Quintana JF.   +4 more
europepmc   +2 more sources

Experimental evidence that immune trypanolysis using the LiTat 1.3 and LiTat 1.5 variant antigen types is not specific to Trypanosoma brucei gambiense in pigs. [PDF]

Parasite, 2022
In the context of the human African trypanosomiasis elimination process, reliable and accurate diagnostic tools are crucial for exploring the role of a potential animal reservoir of Trypanosoma brucei gambiense.
Ilboudo K, Hounyeme RE, Kabore J, Boulangé A, Gimonneau G, Salou E, Belem AGM, Lejon V, Compaoré CFA, Bucheton B, Koffi M, Solano P, Berthier D, Thevenon S, Jamonneau V.   +14 more
europepmc   +2 more sources

Molecular Identification of Trypanosome Diversity in Domestic Animals Reveals the Presence of Trypanosoma brucei gambiense in Historical Foci of Human African Trypanosomiasis in Gabon. [PDF]

Pathogens, 2022
Human African Trypanosomiasis (HAT) is an infectious disease caused by protozoan parasites belonging to the Trypanosoma genus. In sub-Saharan Africa, there is a significant threat as many people are at risk of infection.
Boundenga L, Mombo IM, Augustin MO, Barthélémy N, Nzassi PM, Moukodoum ND, Rougeron V, Prugnolle F.   +7 more
europepmc   +2 more sources

The effect of livestock density on Trypanosoma brucei gambiense and T. b. rhodesiense: A causal inference-based approach. [PDF]

PLoS Negl Trop Dis, 2022
Domestic and wild animals are important reservoirs of the rhodesiense form of human African trypanosomiasis (rHAT), however quantification of this effect offers utility for deploying non-medical control activities, and anticipating their success when ...
Meisner J, Kato A, Lemerani MM, Mwamba Miaka E, Ismail Taban A, Wakefield J, Rowhani-Rahbar A, Pigott DM, Mayer JD, Rabinowitz PM.   +9 more
europepmc   +2 more sources

Trypanosoma brucei gambiense-iELISA: A Promising New Test for the Post-Elimination Monitoring of Human African Trypanosomiasis. [PDF]

Clin Infect Dis, 2021
Background The World Health Organization targeted Trypanosoma brucei gambiense human African trypanosomiasis (gHAT) for elimination as a public health problem and for elimination of transmission. To measure gHAT elimination success with prevalences close
Geerts M, Van Reet N, Leyten S, Berghmans R, Rock KS, Coetzer THT, Eyssen LE, Büscher P.   +7 more
europepmc   +2 more sources