Silent Human Trypanosoma brucei gambiense Infections around the Old Gboko Sleeping Sickness Focus in Nigeria [PDF]
Journal of Parasitology Research, 2016 Trypanosoma brucei gambiense causes Gambian trypanosomosis, a disease ravaging affected rural parts of Sub-Saharan Africa. We screened 1200 human blood samples for T. b.
Karshima Solomon Ngutor +2 more
doaj +4 more sources
Molecular Identification of Trypanosome Diversity in Domestic Animals Reveals the Presence of Trypanosoma brucei gambiense in Historical Foci of Human African Trypanosomiasis in Gabon. [PDF]
Pathogens, 2022 Human African Trypanosomiasis (HAT) is an infectious disease caused by protozoan parasites belonging to the Trypanosoma genus. In sub-Saharan Africa, there is a significant threat as many people are at risk of infection.
Boundenga L +7 more
europepmc +2 more sources
The effect of livestock density on Trypanosoma brucei gambiense and T. b. rhodesiense: A causal inference-based approach. [PDF]
PLoS Negl Trop Dis, 2022 Domestic and wild animals are important reservoirs of the rhodesiense form of human African trypanosomiasis (rHAT), however quantification of this effect offers utility for deploying non-medical control activities, and anticipating their success when ...
Meisner J +9 more
europepmc +2 more sources
The elimination of Trypanosoma brucei gambiense? Challenges of reservoir hosts and transmission cycles: Expect the unexpected. [PDF]
Parasite Epidemiol Control, 2019 Mehlitz D, Molyneux DH.
europepmc +3 more sources
Molecular identification of Trypanosoma brucei gambiense in naturally infected pigs, dogs and small ruminants confirms domestic animals as potential reservoirs for sleeping sickness in Chad. [PDF]
Parasite, 2020 Human African trypanosomiasis (HAT) has been targeted for zero transmission to humans by 2030. Animal reservoirs of gambiense-HAT could jeopardize these elimination goals.
Vourchakbé J +4 more
europepmc +2 more sources
A pilot study demonstrating the identification of Trypanosoma brucei gambiense and T. b. rhodesiense in vectors using a multiplexed high-resolution melt qPCR. [PDF]
PLoS Negl Trop Dis, 2020 Human African Trypanosomiasis (HAT) is a potentially fatal parasitic infection caused by the trypanosome sub-species Trypanosoma brucei gambiense and T. b. rhodesiense transmitted by tsetse flies. Currently, global HAT case numbers are reaching less than
Garrod G +5 more
europepmc +2 more sources
Phospholipase A2fromTrypanosoma brucei gambienseandTrypanosoma brucei brucei: Inhibition by Organotins [PDF]
Journal of Enzyme Inhibition, 2001 Activity and kinetics of phospholipase A2 (PLA2) from Trypanosoma brucei gambiense (Wellcome strain) and Trypanosoma brucei brucei (GUTat 3.1) were examined using two different fluorescent substrates. The activity in the supernatants of sonicated parasites was Ca2+-independent, strongly stimulated by Triton X-100 with optimum activity at 37 degrees C ...
Mohammed Nasir Shuaibu +5 more
openalex +4 more sources
A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense. [PDF]
PLoS Negl Trop Dis, 2016 Humans are protected against infection from most African trypanosomes by lipoprotein complexes present in serum that contain the trypanolytic pore-forming protein, Apolipoprotein L1 (APOL1). The human-infective trypanosomes, Trypanosoma brucei rhodesiense in East Africa and T. b.
Cooper A +7 more
europepmc +7 more sources
Immunoinformatic design of a putative multi-epitope vaccine candidate against Trypanosoma brucei gambiense. [PDF]
Comput Struct Biotechnol J, 2022 Danazumi AU +5 more
europepmc +2 more sources
Efficacy and safety of acoziborole in patients with human African trypanosomiasis caused by Trypanosoma brucei gambiense: a multicentre, open-label, single-arm, phase 2/3 trial. [PDF]
Lancet Infect Dis, 2023 Betu Kumeso VK +30 more
europepmc +2 more sources