Results 21 to 30 of about 18,366 (207)

Molecular identification of Trypanosoma brucei gambiense in naturally infected pigs, dogs and small ruminants confirms domestic animals as potential reservoirs for sleeping sickness in Chad. [PDF]

Parasite, 2020
Human African trypanosomiasis (HAT) has been targeted for zero transmission to humans by 2030. Animal reservoirs of gambiense-HAT could jeopardize these elimination goals.
Vourchakbé J, Tiofack ZAA, Kante TS, Mpoame M, Simo G.   +4 more
europepmc   +2 more sources

A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense. [PDF]

PLoS Negl Trop Dis, 2016
Humans are protected against infection from most African trypanosomes by lipoprotein complexes present in serum that contain the trypanolytic pore-forming protein, Apolipoprotein L1 (APOL1). The human-infective trypanosomes, Trypanosoma brucei rhodesiense in East Africa and T. b.
Cooper A, Capewell P, Clucas C, Veitch N, Weir W, Thomson R, Raper J, MacLeod A.   +7 more
europepmc   +6 more sources

Immunoinformatic design of a putative multi-epitope vaccine candidate against Trypanosoma brucei gambiense. [PDF]

Comput Struct Biotechnol J, 2022
Danazumi AU, Iliyasu Gital S, Idris S, Bs Dibba L, Balogun EO, Górna MW.   +5 more
europepmc   +2 more sources

Prospective evaluation of a rapid diagnostic test for Trypanosoma brucei gambiense infection developed using recombinant antigens. [PDF]

PLoS Negl Trop Dis, 2018
Background Diagnosis and treatment are central elements of strategies to control Trypanosoma brucei gambiense human African trypanosomiasis (HAT). Serological screening is a key entry point in diagnostic algorithms.
Lumbala C, Biéler S, Kayembe S, Makabuza J, Ongarello S, Ndung'u JM.   +5 more
europepmc   +2 more sources

Efficacy and safety of acoziborole in patients with human African trypanosomiasis caused by Trypanosoma brucei gambiense: a multicentre, open-label, single-arm, phase 2/3 trial. [PDF]

Lancet Infect Dis, 2023
Betu Kumeso VK, Kalonji WM, Rembry S, Valverde Mordt O, Ngolo Tete D, Prêtre A, Delhomme S, Ilunga Wa Kyhi M, Camara M, Catusse J, Schneitter S, Nusbaumer M, Mwamba Miaka E, Mahenzi Mbembo H, Makaya Mayawula J, Layba Camara M, Akwaso Massa F, Kaninda Badibabi L, Kasongo Bonama A, Kavunga Lukula P, Mutanda Kalonji S, Mariero Philemon P, Mokilifi Nganyonyi R, Embana Mankiara H, Asuka Akongo Nguba A, Kobo Muanza V, Mulenge Nasandhel E, Fifi Nzeza Bambuwu A, Scherrer B, Strub-Wourgaft N, Tarral A.   +30 more
europepmc   +2 more sources

Unusual MRI Findings in African Trypanosoma brucei gambiense Trypanosomiasis: Dentate Nuclei and Hypothalamic Lesions. [PDF]

Am J Trop Med Hyg, 2020
Monique Boukobza,* Sylvie Lariven, Sandrine Houzé, and Jean-Pierre Laissy Department of Radiology, Assistance Publique-Hôpitaux de Paris, Bichat University Hospital, Paris, France; Infectious and Tropical Diseases Department, Assistance Publique-Hôpitaux
Boukobza M, Lariven S, Houzé S, Laissy JP.   +3 more
europepmc   +2 more sources

A multicentre, randomised, non-inferiority clinical trial comparing a nifurtimox-eflornithine combination to standard eflornithine monotherapy for late stage Trypanosoma brucei gambiense human African trypanosomiasis in Uganda [PDF]

Parasites & Vectors, 2018
BackgroundWhile the combination of nifurtimox and eflornithine (NECT) is currently recommended for the treatment of the late stage human African trypansomiasis (HAT), single-agent eflornithine was still the treatment of choice when this trial commenced ...
Freddie Kansiime, Seraphine Adibaku, C. Wamboga, F. Idi, C. Kato, L. Yamuah, M. Vaillant, D. Kioy, P. Olliaro, E. Matovu   +9 more
semanticscholar   +3 more sources

Development of a camelid single-domain antibody-based antigen detection assay for the pan-specific diagnosis of active human and animal Trypanosoma brucei infections [PDF]

Journal of Clinical Microbiology
Trypanosoma brucei infections cause African trypanosomiasis, also known as sleeping sickness in humans and nagana in animals, presenting a significant global health and economic burden, especially in sub-Saharan Africa.
Zeng Li, Bo-kyung Jin, Emily Estefania Timaury Moreno, Andrés Álvarez-Rodríguez, Jo A. Van Ginderachter, Magdalena Radwanska, Yann G. -J. Sterckx, Benoit Stijlemans, Stefan Magez   +8 more
doaj   +2 more sources

Trypanosoma brucei gambiense Group 2: The Unusual Suspect.

Trends in Parasitology, 2019
Trypanosoma brucei causes human African trypanosomiasis (HAT). Three subspecies were described: T. b. gambiense (Tbg) and T. b. rhodesiense (Tbr) in humans, and T. b. brucei (Tbb) in animals. Molecular markers subdivided Tbg into two groups: Tbg1 and Tbg2, of which the latter is different from Tbg1 and Tbr (absence of the SRA gene), but ...
V. Jamonneau, P. Truc, P. Grébaut, S. Herder, S. Ravel, P. Solano, T. de Meeûs   +6 more
semanticscholar   +6 more sources

Case Report: Trypanosoma brucei Gambiense Human African Trypanosomiasis as the Cause of Fever in an Inpatient with Multiple Myeloma and HIV-1 Coinfection. [PDF]

Am J Trop Med Hyg, 2019
We report the case of a 64-year-old woman found to have urban-acquired Trypanosoma brucei (T.b.) gambiense human African trypanosomiasis (HAT) as the cause of sustained fever starting 9 months after returning to Canada from Democratic Republic of the ...
Boodman C, Libman M, Ndao M, Yansouni CP.   +3 more
europepmc   +2 more sources