Results 41 to 50 of about 7,933 (178)

Free-ranging pigs identified as a multi-reservoir of Trypanosoma brucei and Trypanosoma congolense in the Vavoua area, a historical sleeping sickness focus of Côte d'Ivoire.

PLoS Neglected Tropical Diseases, 2021
BackgroundThe existence of an animal reservoir of Trypanosoma brucei gambiense (T. b. gambiense), the agent of human African trypanosomiasis (HAT), may compromise the interruption of transmission targeted by World Health Organization.
Barkissa Mélika Traoré, Mathurin Koffi, Martial Kassi N'Djetchi, Dramane Kaba, Jacques Kaboré, Hamidou Ilboudo, Bernadin Ahouty Ahouty, Minayégninrin Koné, Bamoro Coulibaly, Thomas Konan, Adeline Segard, Lingué Kouakou, Thierry De Meeûs, Sophie Ravel, Philippe Solano, Jean-Mathieu Bart, Vincent Jamonneau   +16 more
doaj   +1 more source

Human and animal Trypanosomes in Côte d'Ivoire form a single breeding population.

PLoS ONE, 2013
BackgroundTrypanosoma brucei is the causative agent of African Sleeping Sickness in humans and contributes to the related veterinary disease, Nagana. T. brucei is segregated into three subspecies based on host specificity, geography and pathology. T.
Paul Capewell, Anneli Cooper, Craig W Duffy, Andy Tait, C Michael R Turner, Wendy Gibson, Dieter Mehlitz, Annette Macleod   +7 more
doaj   +1 more source

Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei [PDF]

, 2015
Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl ...
De Koning, Harry P., Munday, Jane C., Settimo, Luca   +2 more
core   +1 more source

Loop-mediated isothermal amplification (LAMP) method for rapid detection of Trypanosoma brucei rhodesiense [PDF]

, 2008
Loop-mediated isothermal amplification (LAMP) of DNA is a novel technique that rapidly amplifies target DNA under isothermal conditions. In the present study, a LAMP test was designed from the serum resistance-associated (SRA) gene of Trypanosoma brucei ...
Armstrong, T., Enyaru, J.C., Mikosza, A., Ndung'u, J.M., Njiru, Z.K., Thompson, R.C.A.   +5 more
core   +2 more sources

Human infectivity trait in Trypanosoma brucei: stability, heritability and relationship to sra expression [PDF]

, 2004
Some Trypanosoma brucei lines infect humans whereas others do not because the parasites are lysed by human serum. We have developed a robust, quantitative in vitro assay based on differential uptake of fluorescent dyes by live and dead trypanosomes to ...
Bisoni, L., Lindergard, L.A.G., MacLeod, A., McLellan, S., Tait, A., Turner, C.M.R.   +5 more
core   +1 more source

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei.

PLoS Pathogens, 2014
Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Sam Alsford, Rachel B Currier, José Afonso Guerra-Assunção, Taane G Clark, David Horn   +4 more
doaj   +1 more source

Les glossines de l'agglomération brazzavilloise. III. Rôle vecteur dans les trypanosomoses animales et humaine

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1987
Depuis l'élimination en 1985 des glossines du centre ville de la capitale congolaise, la trypanosomose animale à trypanosoma congolense y a totalement disparu. Cependant, en périphérie Sud de Brazzaville parallélement à l'épizootie à t.
F. Noireau, A. Toudic, J.P. Gouteux, N. Bissadidi, Jean-Louis Frézil, J.P. Duteurtre   +5 more
doaj   +1 more source

Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II). [PDF]

, 2005
BACKGROUND: Treatment of late-stage human African trypanosomiasis (HAT) with melarsoprol can be improved by shortening the regimen. A previous trial demonstrated the safety and efficacy of a 10-day treatment schedule.
Asumu, P, Bilenge, C M M, Burri, C, Chappuis, F, Doua, F, Josenando, T, Manthelot, C R, Nangouma, A, Richer, M, Schmid, C, Simarro, P   +10 more
core   +2 more sources

Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro, Janine Aucamp, Christina Kannigadu, Helena D. Janse van Rensburg, Keisuke Suganuma, David D. N'Da   +5 more
wiley   +1 more source

The challenging problem of disease staging in human African trypanosomiasis (sleeping sickness): a new approach to a circular question [PDF]

, 2017
Human African trypanosomiasis (HAT), also known as sleeping sickness, puts millions of people at risk in sub-Saharan Africa and is a neglected parasitic disease that is almost always fatal if untreated or inadequately treated. HAT manifests itself in two
Gettinby, George, Kennedy, Peter G.E., Njamnshi, Alfred K.   +2 more
core   +1 more source