Results 61 to 70 of about 8,052 (225)

Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro, Janine Aucamp, Christina Kannigadu, Helena D. Janse van Rensburg, Keisuke Suganuma, David D. N'Da   +5 more
wiley   +1 more source

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei.

PLoS Pathogens, 2014
Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Sam Alsford, Rachel B Currier, José Afonso Guerra-Assunção, Taane G Clark, David Horn   +4 more
doaj   +1 more source

Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection

mBio, 2016
African trypanosomes, except Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, which cause human African trypanosomiasis, are lysed by the human serum protein apolipoprotein L1 (ApoL1).
Bart Cuypers, Laurence Lecordier, Conor J. Meehan, Frederik Van den Broeck, Hideo Imamura, Philippe Büscher, Jean-Claude Dujardin, Kris Laukens, Achim Schnaufer, Caroline Dewar, Michael Lewis, Oliver Balmer, Thomas Azurago, Sardick Kyei-Faried, Sally-Ann Ohene, Boateng Duah, Prince Homiah, Ebenezer Kofi Mensah, Francis Anleah, Jose Ramon Franco, Etienne Pays, Stijn Deborggraeve   +21 more
doaj   +1 more source

Exploration of Novel “Ferroxazide/Ferrazone” Derivatives as Antitrypanosomatid Agents: Design, Synthesis, and Biological Efficacy

Applied Organometallic Chemistry, Volume 39, Issue 1, January 2025.
A series of novel ferrocene derivatives, mimics of the clinical antibiotics, nifuroxazide and nitrofurazone, termed ferroxazides and ferrazones, respectively, were synthesized and evaluated for antitrypanosomatid activities. The ferroxazide 15 bearing dimethylamino moiety was identified in vitro as hit against Trypanosoma congolense strain but ...
Christina Kannigadu, Helena D. Janse van Rensburg, Janine Aucamp, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source

Case of Nigeria-Acquired Human African Trypanosomiasis in United Kingdom, 2016

Emerging Infectious Diseases, 2017
Human African trypanosomiasis has not been reported in Nigeria since 2012. Nevertheless, limitations of current surveillance programs mean that undetected infections may persist.
Akish Luintel, Patricia Lowe, Anneli Cooper, Annette MacLeod, Philippe Büscher, Tim Brooks, Mike Brown   +6 more
doaj   +1 more source

Diagnostic accuracy of loopamp Trypanosoma brucei detection kit for diagnosis of human African trypanosomiasis in clinical samples. [PDF]

PLoS Neglected Tropical Diseases, 2013
BACKGROUND: Molecular methods have great potential for sensitive parasite detection in the diagnosis of human African trypanosomiasis (HAT), but the requirements in terms of laboratory infrastructure limit their use to reference centres.
Patrick Mitashi, Epco Hasker, Dieudonné Mumba Ngoyi, Pati Patient Pyana, Veerle Lejon, Wim Van der Veken, Pascal Lutumba, Philippe Büscher, Marleen Boelaert, Stijn Deborggraeve   +9 more
doaj   +1 more source

Plasma neuronal specific enolase : a potential stage diagnostic marker in human African trypanosomiasis [PDF]

, 2014
© The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Mitchell, Julia A, Sternberg, Jeremy M
core   +1 more source

Neglected Tropical Diseases and Female Infertility: Possible Pathophysiological Mechanisms

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
Battling female infertility has posed a global challenge, where neglected tropical diseases (NTDs) are nonetheless a notable contributing factor. NTDs affect a variety of diseases, often of a chronic nature, which are often cited as some of the most lethal diseases operating against the most economically disadvantaged populations across the globe.
Moses Agbomhere Hamed, Olabanji Ahmed Surakat, Victor Olukayode Ekundina, Kabirat Bolajoko Jimoh, Adetomiwa Ezekiel Adeogun, Nafisat Omolola Akanji, Oluwafemi Joshua Babalola, Patrick Chukwunonso Eya, Rajib Chowdhury   +8 more
wiley   +1 more source

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]

, 2009
Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Adams, B. Bradley, Clark, Eastman, Eastman, Giles, Gonzalez, Guidetti, Hirumi, J. Rodgers, Jennings, Jennings, Jhamandas, Kamleh, Kennedy, Kennedy, Kennedy, Kennedy, M. P. Barrett, Moffett, Okuda, Okuda, P. G. E. Kennedy, Pepin, Perkins, Pfefferkorn, P  pin, R  z, Sanni, Schroten, Schwarcz, Smith, Sternberg, Stone, Stone, Stone, T. W. Stone, Vincendeau   +37 more
core   +2 more sources

ESI MS Studies of T. Brucei Trypanothione Reductase and its Reactions With Selected Metal Compounds

European Journal of Inorganic Chemistry, Volume 27, Issue 36, December 20, 2024.
The study investigates the interactions between Trypanothione reductase from Trypanosoma brucei (TbTR) and selected metal compounds using ESI‐MS measurements. The findings describe how these compounds bind to TbTR, highlighting their potential as novel anti‐parasitic agents by targeting this crucial enzyme, which is essential for the parasite's ...
Stefano Zineddu, Andrea Geri, Andrea Ilari, Gianni Colotti, Cécile Exertier, Annarita Fiorillo, Lorenzo Antonelli, Luigi Messori   +7 more
wiley   +1 more source