Results 81 to 90 of about 7,933 (178)

Behandlung der mukokutanen Leishmaniose – eine systematische Übersicht

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 22, Issue 6, Page 763-774, June 2024.
Zusammenfassung Die mukokutane Leishmaniose ist eine schwere Infektionskrankheit, die überwiegend in Zentral‐ und Südamerika endemisch ist und sich klinisch mit granulomatösen, destruierenden Schleimhautläsionen im Mund‐Nasen‐Rachenraum manifestiert. Sie wird durch Protozoen, Leishmania spp., ausgelöst, die durch Sandmücken auf den Menschen übertragen ...
Theresa Fischer, Marcellus Fischer, Sibylle Schliemann, Peter Elsner   +3 more
wiley   +1 more source

Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific [PDF]

, 2007
Background: In a mammalian host, the cell surface of African trypanosomes is protected by a monolayer of a single variant surface glycoprotein (VSG). The VSG is central to antigenic variation; one VSG gene is expressed at any one time and there is a low ...

core   +1 more source

Nanobodies as tools to understand, diagnose, and treat African trypanosomiasis [PDF]

, 2017
African trypanosomes are strictly extracellular protozoan parasites that cause diseases in humans and livestock and significantly affect the economic development of sub-Saharan Africa.
Caljon, Guy, De Baetselier, Patrick, Magez, Stefan, Stijlemans, Benoit, Van Den Abbeele, Jan, Van Ginderachter, Jo A   +5 more
core   +1 more source

Isolation and analysis of the genetic diversity of repertoires of VSG expression site containing telomeres from Trypanosoma brucei gambiense, T. b. brucei and T. equiperdum

BMC Genomics, 2008
Background African trypanosomes (including Trypanosoma brucei) are unicellular parasites which multiply in the mammalian bloodstream. T. brucei has about twenty telomeric bloodstream form Variant Surface Glycoprotein (VSG) expression sites (BESs), of ...
Becker Marion, Kurioka Ayako, Taylor Jesse E, Young Rosanna, Louis Edward J, Rudenko Gloria   +5 more
doaj   +1 more source

Tractable Quinolone Hydrazides Exhibiting Sub‐Micromolar and Broad Spectrum Antitrypanosomal Activities

ChemMedChem, Volume 19, Issue 9, May 2, 2024.
Several (sub)species of Trypanosoma are responsible for human African trypanosomiasis (HAT), Chagas disease, and Nagana. These (sub)species have different drug susceptibility profiles. This work reports several easily accessed quinolone hydrazides exhibiting sub‐micromolar activities against multiple (sub)species of Trypanosoma.
Kgothatso A. Chirwa, Karol R. Francisco, Phelelisiwe S. Dube, Hayoung Park, Lesetja J. Legoabe, Thaiz Rodrigues Teixeira, Conor R. Caffrey, Richard M. Beteck   +7 more
wiley   +1 more source

Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis [PDF]

, 2017
Although Trypanosoma brucei spp. was first detected by Aldo Castellani in CSF samples taken from sleeping sickness patients over a century ago there is still a great deal of debate surrounding the timing, route and effects of transmigration of the ...
Bradley, Barbara, Kennedy, Peter G.E., Rodgers, Jean   +2 more
core   +1 more source

In vitro anti‐trypanosomal activity of synthetic nitrofurantoin‐triazole hybrids against Trypanosoma species causing human African trypanosomosis

Fundamental &Clinical Pharmacology, Volume 38, Issue 1, Page 72-83, February 2024.
Abstract Human African trypanosomosis (HAT) which is also known as sleeping sickness is caused by Trypanosoma brucei gambiense that is endemic in western and central Africa and T. b. rhodesiense that is endemic in eastern and southern Africa. Drugs used for treatment against HAT first stage have limited effectiveness, and the second stage drugs have ...
Anna Seetsi, David D. N'da, Nthatisi Molefe‐Nyembe, Keisuke Suganuma, Tsepo Ramatla, Oriel Thekisoe   +5 more
wiley   +1 more source

Recherche du réservoir animal sauvage de Trypanosoma sp chez les mammifères de N'Djili-Brasseries à  Kinshasa en République Démocratique du Congo (RDC)

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2017
Durant 6 mois, 201 spécimens de mammifères sauvages représentant 7 espèces réparties en 6 genres, 4 familles et 3 ordres, dont 2 Genetta angolensis, 3 Nandinia binotata, 10 Galagoides demidoff, 35 Protoxerus strangeri, 73 Funisciurus congicus, 15 Rattus
Matthieu Willy KABAMBA MWAMBA, Curé Georges TSHILENGE MBUYI, J. MALEKANI   +2 more
doaj  

African Trypanosomiasis Gambiense, Italy

Emerging Infectious Diseases, 2005
African trypanosomiasis caused by Trypanosoma brucei gambiense has not been reported in Italy. We report 2 cases diagnosed in the summer of 2004. Theses cases suggest an increased risk for expatriates working in trypanosomiasis-endemic countries.
Zeno Bisoffi, Anna Beltrame, Geraldo Monteiro, Alessandra Arzese, Stefania Marocco, Giada Rorato, Mariella Anselmi, Pierluigi Viale   +7 more
doaj   +1 more source

Quercetin as a Promising Antiprotozoan Phytochemical: Current Knowledge and Future Research Avenues

BioMed Research International, Volume 2024, Issue 1, 2024.
Despite tremendous advances in the prevention and treatment of infectious diseases, only few antiparasitic drugs have been developed to date. Protozoan infections such as malaria, leishmaniasis, and trypanosomiasis continue to exact an enormous toll on public health worldwide, underscoring the need to discover novel antiprotozoan drugs. Recently, there
Hamed Memariani, Mojtaba Memariani, Abdolmajid Ghasemian, Rahul Shivahare   +3 more
wiley   +1 more source