Results 81 to 90 of about 18,054 (201)

Potential Trypanocidal Activity of Glycerol Analogues

ChemistryOpen, Volume 13, Issue 12, December 2024.
Trypanosoma brucei is a unicellular parasitic flagellate protozoa causing human African trypanosomiasis and animal African trypanosomiasis. Synthesised glycerol analogues were tested for their potential trypanocidal affects. They caused morphological changes, including detached flagella, cytokinesis defects and ‘big‐eye’ phenotype.
R. A. Humann, T. K. Smith
wiley   +1 more source

Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by trypanolytic factor 1.

PLoS Neglected Tropical Diseases, 2011
BackgroundThe three sub-species of Trypanosoma brucei are important pathogens of sub-Saharan Africa. T. b. brucei is unable to infect humans due to sensitivity to trypanosome lytic factors (TLF) 1 and 2 found in human serum. T. b. rhodesiense and T.
Paul Capewell, Nicola J Veitch, C Michael R Turner, Jayne Raper, Matthew Berriman, Stephen L Hajduk, Annette MacLeod   +6 more
doaj   +1 more source

P-type transport ATPases in Leishmania and Trypanosoma

Parasite, 2019
P-type ATPases are critical to the maintenance and regulation of cellular ion homeostasis and membrane lipid asymmetry due to their ability to move ions and phospholipids against a concentration gradient by utilizing the energy of ATP hydrolysis.
Meade John C.
doaj   +1 more source

Vector competence of sterile male Glossina fuscipes fuscipes for Trypanosoma brucei brucei: implications for the implementation of the sterile insect technique in a sleeping sickness focus in Chad

Parasites & Vectors, 2023
Background Human African trypanosomiasis (HAT) is a neglected tropical disease caused by Trypanosoma brucei gambiense transmitted by tsetse flies in sub-Saharan West Africa. In southern Chad the most active and persistent focus is the Mandoul focus, with
Mahamat Hissene Mahamat, Adeline Ségard, Jean-Baptiste Rayaisse, Rafael Argiles-Herrero, Andrew Gordon Parker, Philippe Solano, Adly Mohamed Mohamed Abd-Alla, Jérémy Bouyer, Sophie Ravel   +8 more
doaj   +1 more source

Synthesis and photodynamic activity of new 5‐[(E)‐2‐(3‐alkoxy‐1‐phenyl‐1H‐pyrazol‐4‐yl)ethenyl]‐2‐phenyl‐3H‐indoles

Archiv der Pharmazie, Volume 357, Issue 10, October 2024.
Upon blue light irradiation, the indole‐pyrazole hybrid 8d induces a massive generation of reactive oxygen species in breast cancer cells, leading to different types of cell death depending on the concentration of 8d and the intensity of irradiation. Abstract A series of new indole‐pyrazole hybrids 8a–m were synthesized through the palladium‐catalyzed ...
Gabrielė Varvuolytė, Eva Řezníčková, Aurimas Bieliauskas, Neringa Kleizienė, Veronika Vojáčková, Alena Opichalová, Asta Žukauskaitė, Vladimír Kryštof, Algirdas Šačkus   +8 more
wiley   +1 more source

Comparative analysis of cerebrospinal fluid from the meningo-encephalitic stage of T. b. gambiense and rhodesiense sleeping sickness patients using TMT quantitative proteomics

Data in Brief, 2015
The quantitative proteomics data here reported are part of a research article entitled “Increased acute immune response during the meningo-encephalitic stage of Trypanosoma brucei rhodesiense sleeping sickness compared to Trypanosoma brucei gambiense ...
Natalia Tiberti, Jean-Charles Sanchez
doaj   +1 more source

Identification of Peptide Mimotopes of Trypanosoma brucei gambiense Variant Surface Glycoproteins

PLoS Neglected Tropical Diseases, 2011
The current antibody detection tests for the diagnosis of gambiense human African trypanosomiasis (HAT) are based on native variant surface glycoproteins (VSGs) of Trypanosoma brucei (T.b.) gambiense. These native VSGs are difficult to produce, and contain non-specific epitopes that may cause cross-reactions. We aimed to identify mimotopic peptides for
Van Nieuwenhove, Liesbeth, Roge, Stijn, Balharbi, Fatima, Dieltjens, Tessa, Laurent, Thierry, Guisez, Yves, Buscher, Philippe, Lejon, Veerle   +7 more
openaire   +6 more sources

Hydrazinated geraniol derivatives as potential broad‐spectrum antiprotozoal agents

Archiv der Pharmazie, Volume 357, Issue 10, October 2024.
Hydrazinated geraniol derivatives were synthesised and tested in vitro against different parasitic protozoans of clinical relevance, including Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense, Trypanosoma cruzi and Leishmania infantum. Compounds 6, 8, 13, 14 and 15 demonstrated low micromolar activity against the different parasites.
Joelien Jooste, Lesetja J. Legoabe, Kayhan Ilbeigi, Guy Caljon, Richard M. Beteck   +4 more
wiley   +1 more source

Search for the wild animal reservoir of Trypanosoma sp in mammals of N’Djili-Brasseries (Kinshasa, Democratic Republic of Congo)

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2018
During 6 months, 201 specimens of wild mammals representing 7 species divided into 6 genera, 4 families and 3 orders, of which 2 Genetta angolensis, 3 Nandinia binotata, 10 Galagoides demidoff, 35 Protoxerus strangeri, 73 Funisciurus congicus, 15 Rattus ...
M.W. Kabamba Mwamba, G. Tshilenge, J. Malekani   +2 more
doaj  

Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model. [PDF]

PLoS Neglected Tropical Diseases, 2016
Trypanosoma brucei gambiense is the main causative agent of Human African Trypanosomiasis (HAT), also known as sleeping sickness. Because of limited alternatives and treatment toxicities, new therapeutic options are urgently needed for patients with HAT.
Frédéric-Antoine Dauchy, Mélanie Bonhivers, Nicolas Landrein, Denis Dacheux, Pierrette Courtois, Florian Lauruol, Sylvie Daulouède, Philippe Vincendeau, Derrick R Robinson   +8 more
doaj   +1 more source