Population genetics of Trypanosoma brucei rhodesiense: clonality and diversity within and between foci. [PDF]
PLoS Neglected Tropical Diseases, 2013 African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development.
Craig W Duffy +8 more
doaj +74 more sources
Development of Novel Isoindolone‐Based Compounds against Trypanosoma brucei rhodesiense [PDF]
ChemistryOpen, 2021 This study identified the isoindolone ring as a scaffold for novel agents against Trypanosoma brucei rhodesiense and explored the structure‐activity relationships of various aromatic ring substitutions.
Dr. Daniel G. Silva +8 more
doaj +7 more sources
Reemergence of Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense, Ethiopia [PDF]
Emerging Infectious DiseasesWe report 4 cases of human African trypanosomiasis that occurred in Ethiopia in 2022, thirty years after the last previously reported case in the country. Two of 4 patients died before medicine became available.
Adugna Abera +26 more
doaj +4 more sources
Whole-Genome Sequencing of
mBio, 2013 Human African trypanosomiasis is caused by two subspecies of Trypanosoma brucei. Trypanosoma brucei rhodesiense is found in East Africa and frequently causes acute disease, while Trypanosoma brucei gambiense is found in West Africa and is associated with
Ian Goodhead +10 more
doaj +7 more sources
PLoS Neglected Tropical Diseases, 2020 Human African Trypanosomiasis (HAT) is a potentially fatal parasitic infection caused by the trypanosome sub-species Trypanosoma brucei gambiense and T. b. rhodesiense transmitted by tsetse flies. Currently, global HAT case numbers are reaching less than
Gala Garrod +5 more
doaj +3 more sources
Dynamical and optimal control analysis of a seasonal Trypanosoma brucei rhodesiense model
Mathematical Biosciences and Engineering, 2020 The effects of seasonal variations on the epidemiology of Trypanosoma brucei rhodesiense disease is well documented. In particular, seasonal variations alter vector development rates and behaviour, thereby influencing the transmission dynamics of the ...
Mlyashimbi Helikumi +3 more
doaj +2 more sources
Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in tsetse in Serengeti, Tanzania. [PDF]
PLoS Neglected Tropical Diseases, 2012 BackgroundMeasuring the prevalence of transmissible Trypanosoma brucei rhodesiense in tsetse populations is essential for understanding transmission dynamics, assessing human disease risk and monitoring spatio-temporal trends and the impact of control ...
Harriet K Auty +5 more
doaj +8 more sources
Dipeptide Nitrile CD34 with Curcumin: A New Improved Combination Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense. [PDF]
Int J Mol Sci, 2023 Di Chio C +7 more
europepmc +3 more sources
Development of a camelid single-domain antibody-based antigen detection assay for the pan-specific diagnosis of active human and animal Trypanosoma brucei infections [PDF]
Journal of Clinical MicrobiologyTrypanosoma brucei infections cause African trypanosomiasis, also known as sleeping sickness in humans and nagana in animals, presenting a significant global health and economic burden, especially in sub-Saharan Africa.
Zeng Li +8 more
doaj +2 more sources
Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense. [PDF]
Int J Mol Sci, 2022 Di Chio C +8 more
europepmc +3 more sources