Results 1 to 10 of about 9,819 (155)

Development of Novel Isoindolone‐Based Compounds against Trypanosoma brucei rhodesiense [PDF]

ChemistryOpen, 2021
This study identified the isoindolone ring as a scaffold for novel agents against Trypanosoma brucei rhodesiense and explored the structure‐activity relationships of various aromatic ring substitutions.
Dr. Daniel G. Silva, Pim‐Bart Feijens, Rik Hendrickx, An Matheeussen, Lucie Grey, Prof. Dr. Guy Caljon, Prof. Dr. Louis Maes, Prof. Dr. Flavio S. Emery, Dr. Anna Junker   +8 more
doaj   +7 more sources

Reemergence of Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense, Ethiopia [PDF]

Emerging Infectious Diseases
We report 4 cases of human African trypanosomiasis that occurred in Ethiopia in 2022, thirty years after the last previously reported case in the country. Two of 4 patients died before medicine became available.
Adugna Abera, Tihitina Mamecha, Ebise Abose, Belachew Bokicho, Agune Ashole, Tesfahun Bishaw, Abinet Mariyo, Buzayehu Bogale, Haileyesus Terefe, Henok Tadesse, Mahlet Belachew, Hailemariam Difabachew, Araya Eukubay, Solomon Kinde, Abraham Ali, Feyesa Regasa, Fikre Seife, Zeyede Kebede, Mesfin Wossen, Getachew Tollera, Mesay Hailu, Nigus Manaye, Nick Van Reet, Gerardo Priotto, Johan van Griensven, Myrthe Pareyn, Geremew Tasew   +26 more
doaj   +4 more sources

C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. [PDF]

PLoS Pathogens, 2009
Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T.
Laurence Lecordier, Benoit Vanhollebeke, Philippe Poelvoorde, Patricia Tebabi, Françoise Paturiaux-Hanocq, Fabienne Andris, Laurence Lins, Etienne Pays   +7 more
doaj   +5 more sources

Development of a camelid single-domain antibody-based antigen detection assay for the pan-specific diagnosis of active human and animal Trypanosoma brucei infections [PDF]

Journal of Clinical Microbiology
Trypanosoma brucei infections cause African trypanosomiasis, also known as sleeping sickness in humans and nagana in animals, presenting a significant global health and economic burden, especially in sub-Saharan Africa.
Zeng Li, Bo-kyung Jin, Emily Estefania Timaury Moreno, Andrés Álvarez-Rodríguez, Jo A. Van Ginderachter, Magdalena Radwanska, Yann G. -J. Sterckx, Benoit Stijlemans, Stefan Magez   +8 more
doaj   +2 more sources

Haemoparasitic Infections in Cattle from a Trypanosoma brucei Rhodesiense Sleeping Sickness Endemic District of Eastern Uganda [PDF]

Tropical Medicine and Infectious Disease, 2020
We carried out a baseline survey of cattle in Kaberamaido district, in the context of controlling the domestic animal reservoir of Trypanosoma brucei rhodesiense human African trypanosomiasis (rHAT) towards elimination.
Enock Matovu, Claire Mack Mugasa, Peter Waiswa, Annah Kitibwa, Alex Boobo, Joseph Mathu Ndung’u   +5 more
doaj   +2 more sources

Therapeutic Strategies against Leishmania and Trypanosoma

Pathogens, 2023
Human African trypanosomiasis (also known as sleeping sickness, with Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense as etiological agents), American trypanosomiasis (also known as Chagas disease, with Trypanosoma cruzi as the etiological
André L. S. Santos, Igor A. Rodrigues, Claudia M. d’Avila-Levy, Cátia L. Sodré, Koert Ritmeijer, Marta H. Branquinha   +5 more
doaj   +1 more source

Epidemiology of Trypanosomiasis in Wildlife—Implications for Humans at the Wildlife Interface in Africa

Frontiers in Veterinary Science, 2021
While both human and animal trypanosomiasis continue to present as major human and animal public health constraints globally, detailed analyses of trypanosome wildlife reservoir hosts remain sparse.
Keneth Iceland Kasozi, Keneth Iceland Kasozi, Gerald Zirintunda, Fred Ssempijja, Bridget Buyinza, Khalid J. Alzahrani, Kevin Matama, Helen N. Nakimbugwe, Helen N. Nakimbugwe, Luay Alkazmi, David Onanyang, Paul Bogere, Juma John Ochieng, Saher Islam, Wycliff Matovu, David Paul Nalumenya, Gaber El-Saber Batiha, Lawrence Obado Osuwat, Mahmoud Abdelhamid, Tianren Shen, Tianren Shen, Leonard Omadang, Susan Christina Welburn, Susan Christina Welburn   +23 more
doaj   +1 more source

Suramin action in African trypanosomes involves a RuvB-like DNA helicase

International Journal for Parasitology: Drugs and Drug Resistance, 2023
Suramin is one of the oldest drugs in use today. It is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense, and it is also used for surra in camels caused by Trypanosoma evansi ...
Anna Albisetti, Silvan Hälg, Martin Zoltner, Pascal Mäser, Natalie Wiedemar   +4 more
doaj   +1 more source

Recommendations for control of East African sleeping sickness in Uganda

Journal of Global Infectious Diseases, 2010
East African sleeping sickness, caused by Trypanosoma brucei rhodesiense, is prominent in Uganda and poses a serious public health challenge in the region.
Simon Kotlyar
doaj   +3 more sources

Whole-Genome Sequencing of Trypanosoma brucei Reveals Introgression between Subspecies That Is Associated with Virulence

mBio, 2013
Human African trypanosomiasis is caused by two subspecies of Trypanosoma brucei. Trypanosoma brucei rhodesiense is found in East Africa and frequently causes acute disease, while Trypanosoma brucei gambiense is found in West Africa and is associated with
Ian Goodhead, Paul Capewell, J. Wendi Bailey, Tanja Beament, Michael Chance, Suzanne Kay, Sarah Forrester, Annette MacLeod, Mark Taylor, Harry Noyes, Neil Hall   +10 more
doaj   +1 more source