PLoS Neglected Tropical Diseases, 2011 BackgroundAnimal and human trypanosomiasis are constraints to both animal and human health in Sub-Saharan Africa, but there is little recent evidence as to how these parasites circulate in wild hosts in natural ecosystems.
Neil E Anderson +6 more
doaj +1 more source
Through the dark continent: African trypanosome development in the tsetse fly [PDF]
, 2013 African trypanosomes are unicellular flagellated parasites causing trypanosomiases in Africa, a group of severe diseases also known as sleeping sickness in human and nagana in cattle.
Rotureau, Brice, Van Den Abbeele, Jan
core +4 more sources
Mathematical models of trypanosoma brucei rhodesiense disease transmission and control strategies [PDF]
, 2021 Mlyashimbi Helikumi
openalex +1 more source
Examining marginal sequence similarities between bacterial type III secretion system and Trypanosoma cruzi surface proteins: Horizontal gene transfer or convergent evolution? [PDF]
arXiv, 2012 The cell invasion mechanism of Trypanosoma cruzi has similarities with some intracellular bacterial taxa especially regarding calcium mobilization. This mechanism is not observed in other trypanosomatids, suggesting that the molecules involved in this type of cell invasion were a product of (1) acquired by horizontal gene transfer; (2) secondary loss ...
arxiv
Natural Product Research, 2018 Recently, it was suggested that curcumin is an irreversible inhibitor of rhodesain, a cathepsin L-like cysteine protease found in the lysosome of the protozoan parasite Trypanosoma brucei.
D. Steverding
semanticscholar +1 more source
Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents
Pharmaceuticals, 2016 A series of 15 alkanediamide-linked bisbenzamidines and related analogs was synthesized and tested in vitro against two Trypanosoma brucei (T.b.) subspecies: T.b. brucei and T.b.
Jean J. Vanden Eynde +7 more
doaj +1 more source
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]
, 2009 Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Adams +37 more
core +2 more sources
A model for African trypanosome cell motility and quantitative description of flagellar dynamics [PDF]
arXiv, 2004 A quantitative description of the flagellar dynamics in the procyclic T. brucei is presented in terms of stationary oscillations and traveling waves. By using digital video microscopy to quantify the kinematics of trypanosome flagellar waveforms. A theoretical model is build starting from a Bernoulli-Euler flexural-torsional model of an elastic string ...
arxiv
Analysis of dysautonomia in patients with Chagas Cardiomyopathy [PDF]
arXiv, 2019 Chagas disease American trypanosomiasis is caused by a flagellated parasite: trypanosoma cruzi, transmitted by an insect of the genus Triatoma and also by blood transfusions. In Latin America the number of infected people is approximately 6 million, with a population exposed to the risk of infection of 550000.
arxiv
Development of a safer laboratory vervet monkey model for the study of human African trypanosomiasis
African Journal of Laboratory Medicine, 2014 Background: There are three subspecies of Trypanosoma brucei: T. b. gambiense, T. b. rhodesiense and T. b. brucei. The first two are infectious to humans, whilst T. b. brucei is not. Identifying an animal model of T. b.
Maxwell Waema +5 more
doaj +1 more source