Results 151 to 160 of about 22,217 (248)

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer, Agbe, Bruhn, Brun, Cristodero, Dean, Deterding, Herbert, Hoare, Holmes, Kaminsky, Lai, Lanteri, M. K. Gould, Mathis, Mukherjee, Painter, Priest, Roy Chowdhury, Räz, Schnaufer, Schnaufer, Schnaufer, Shapiro, Stuart, Tang, Thuita, Ward, Wenzler, Wenzler, Wilson, Zhang, Zuma   +32 more
core   +1 more source

Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents

Marine Drugs, 2013
Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC50 3.1 μM) and Plasmodium falciparum (K1 dual drug resistant ...
Marcel Kaiser, Brent R. Copp, A. Norrie Pearce, Shen H. Tan, Cary F. C. Lam   +4 more
doaj   +1 more source

Dipeptide Nitrile CD34 with Curcumin: A New Improved Combination Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense. [PDF]

Int J Mol Sci, 2023
Di Chio C, Previti S, Totaro N, De Luca F, Allegra A, Schirmeister T, Zappalà M, Ettari R.   +7 more
europepmc   +1 more source

Factors associated with acquisition of human infective and animal infective trypanosome infections in domestic livestock in Western Kenya.

PLoS Neglected Tropical Diseases, 2011
BackgroundTrypanosomiasis is regarded as a constraint on livestock production in Western Kenya where the responsibility for tsetse and trypanosomiasis control has increasingly shifted from the state to the individual livestock owner.
Beatrix von Wissmann, Noreen Machila, Kim Picozzi, Eric M Fèvre, Barend M deC Bronsvoort, Ian G Handel, Susan C Welburn   +6 more
doaj   +1 more source

Efficacy of common laboratory disinfectants and heat on killing trypanosomatid parasites [PDF]

, 2008
The disinfectants TriGene, bleach, ethanol and liquid hand soap, and water and temperature were tested for their ability to kill bloodstream forms of Trypanosoma brucei, epimastigotes of Trypanosoma rangeli and promastigotes of Leishmania major.
Dietmar Steverding, Kevin M Tyler, Momodou Jobe, Wang, Xia, Xia Wang   +4 more
core   +2 more sources

The kinetics of gene expression and maturation of IL-1 alpha after induction with the surface coat of Trypanosoma brucei rhodesiense or lipopolysaccharide. [PDF]

, 1990
Álvaro Luiz Mathias, Ramon Lopez Perez, Peter Diffley   +2 more
openalex   +1 more source

Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response. [PDF]

Int J Mol Sci, 2022
Costa TFR, Goundry A, Morrot A, Grab DJ, Mottram JC, Lima APCA.   +5 more
europepmc   +1 more source

Stellungnahme der ZKBS zur Einstufung der Parasiten Leishmania brasiliensis, Leishmania donovani, Plasmodium falciparum und Trypanosoma brucei rhodesiense als Empfängerorganismen bei gentechnischen Arbeiten [PDF]

, 2001

openalex   +1 more source

High frequency of antigenic variation inTrypanosoma brucei rhodesienseinfections

Parasitology, 1989
SUMMARYRates at whichTrypanosoma bruceirhodesiense trypanosomes switch from expression of one variable antigen type (VAT) to that of another have been determined in cloned populations that have been recently tsetse-fly transmitted. Switching rates have been determined between several, specific pairs of VATs in each population.
James D. Barry, C. M. R. Turner
openaire   +3 more sources

Trypanocidal Activity of Marine Natural Products

Marine Drugs, 2013
Marine natural products are a diverse, unique collection of compounds with immense therapeutic potential. This has resulted in these molecules being evaluated for a number of different disease indications including the neglected protozoan diseases, human
Amy J. Jones, Tanja Grkovic, Melissa L. Sykes, Vicky M. Avery   +3 more
doaj   +1 more source