Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. [PDF]
Cell Mol Life Sci, 2016 Trypanosoma brucei rhodesiense is one of the causative agents of human sleeping sickness, a fatal disease that is transmitted by tsetse flies and restricted to Sub-Saharan Africa. Here we investigate two independent lines of T. b.
Graf FE +13 more
europepmc +8 more sources
De Novo Genome Assembly Shows Genome Wide Similarity between Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. [PDF]
PLoS ONE, 2016 BACKGROUND:Trypanosoma brucei is a eukaryotic pathogen which causes African trypanosomiasis. It is notable for its variant surface glycoprotein (VSG) coat, which undergoes antigenic variation enabled by a large suite of VSG pseudogenes, allowing for ...
Mark Sistrom +5 more
doaj +7 more sources
The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness. [PDF]
Allergy Asthma Clin Immunol, 2016 Human African trypanosomiasis due to Trypanosoma brucei rhodesiense is invariably fatal if untreated with up to 12.3 million people at a risk of developing the disease in Sub-Saharan Africa.
Kato CD +4 more
europepmc +6 more sources
Localization of serum resistance-associated protein in Trypanosoma brucei rhodesiense and transgenic Trypanosoma brucei brucei. [PDF]
Cell Microbiol, 2015 African trypanosomes infect a broad range of mammals, but humans and some higher primates are protected by serum trypanosome lytic factors that contain apolipoprotein L1 (ApoL1). In the human‐infective subspecies of Trypanosoma brucei, Trypanosoma brucei
Bart JM +8 more
europepmc +9 more sources
Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense. [PDF]
Int J Mol Sci, 2022 Rhodesain is a cysteine protease that is crucial for the life cycle of Trypanosoma brucei rhodesiense, a parasite causing the lethal form of Human African Trypanosomiasis.
Di Chio C +8 more
europepmc +2 more sources
The Alkaloid-Enriched Fraction of Pachysandra terminalis (Buxaceae) Shows Prominent Activity against Trypanosoma brucei rhodesiense. [PDF]
Molecules, 2021 In the course of our studies on antiprotozoal natural products and following our recent discovery that certain aminosteroids and aminocycloartanoid compounds from Holarrhena africana A. DC. (Apocynaceae) and Buxus sempervirens L. (Buxaceae), respectively,
Flittner D +4 more
europepmc +2 more sources
Persistently High Incidences of Trypanosoma brucei rhodesiense Sleeping Sickness With Contrasting Focus-Dependent Clinical Phenotypes in Malawi [PDF]
Frontiers in Tropical Diseases, 2022 Background Human African trypanosomiasis (HAT) has caused social–economic burden in remote rural communities mostly in sub-Saharan Africa for over a century.
P. Nambala +8 more
semanticscholar +2 more sources
Plasma cytokines quantification among Trypanosoma brucei rhodesiense sleeping sickness cases and controls in Rumphi, Malawi. [PDF]
Malawi Med J, 2021 Introduction Trypanosoma brucei (T.b.) rhodesiense is the cause of the acute form of human African trypanosomiasis (HAT) in eastern and southern African countries, including Malawi. For a long time, untreated HAT infections were believed to be 100% fatal.
Kamoto K +7 more
europepmc +2 more sources
Decolonising Parasitology: The Case of Trypanosoma brucei rhodesiense.
Trends in Parasitology, 2021 Trypanosoma brucei rhodesiense was named after Rhodesia which, in turn, was named after the British imperialist and white supremacist Cecil Rhodes. In the light of the Black Lives Matter movement and contemporary consciousness of postcolonial legacy, it seems opportune to reconsider the subspecies name. Pros and cons of renaming T. b.
D. Steverding, K. Tyler
semanticscholar +6 more sources
Drug Synergism: Studies of Combination of RK-52 and Curcumin against Rhodesain of Trypanosoma brucei rhodesiense. [PDF]
ACS Med Chem Lett, 2020 Rhodesain is an enzyme essential for the life of Trypanosoma brucei rhodesiense, a parasite causing a rapid-onset form of Human African Trypanosomiasis. RK-52 is a synthetic inhibitor of rhodesain, characterized by an impressive k second value (k second =
Ettari R +6 more
europepmc +2 more sources