C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. [PDF]
PLoS Pathogens, 2009 Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T.
Laurence Lecordier +7 more
doaj +6 more sources
Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. [PDF]
Cell Mol Life Sci, 2016 Trypanosoma brucei rhodesiense is one of the causative agents of human sleeping sickness, a fatal disease that is transmitted by tsetse flies and restricted to Sub-Saharan Africa. Here we investigate two independent lines of T. b. rhodesiense that have been selected with the drugs melarsoprol and pentamidine over the course of 2 years, until they ...
Graf FE +13 more
europepmc +8 more sources
De Novo Genome Assembly Shows Genome Wide Similarity between Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. [PDF]
PLoS ONE, 2016 BACKGROUND:Trypanosoma brucei is a eukaryotic pathogen which causes African trypanosomiasis. It is notable for its variant surface glycoprotein (VSG) coat, which undergoes antigenic variation enabled by a large suite of VSG pseudogenes, allowing for ...
Mark Sistrom +5 more
doaj +5 more sources
Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host. [PDF]
PLoS Negl Trop Dis, 2021 Levy DJ +7 more
europepmc +3 more sources
Haemoparasitic Infections in Cattle from a Trypanosoma brucei Rhodesiense Sleeping Sickness Endemic District of Eastern Uganda [PDF]
Tropical Medicine and Infectious Disease, 2020 We carried out a baseline survey of cattle in Kaberamaido district, in the context of controlling the domestic animal reservoir of Trypanosoma brucei rhodesiense human African trypanosomiasis (rHAT) towards elimination.
Enock Matovu +5 more
doaj +2 more sources
Target product profile: diagnostic test for <i>Trypanosoma brucei rhodesiense</i>. [PDF]
Bull World Health Organ, 2023 Rhodesiense human African trypanosomiasis is a lethal parasitic infection caused by Trypanosoma brucei rhodesiense and transmitted by tsetse flies in eastern and southern Africa. It accounts for around 5% of all cases of human African trypanosomiasis.
Priotto G +14 more
europepmc +3 more sources
Plasma Neuron-Specific Enolase is not a reliable biomarker for staging Trypanosoma brucei rhodesiense sleeping sickness patients. [PDF]
BMC Res Notes, 2022 Kato CD +6 more
europepmc +3 more sources
Association of APOL1 renal disease risk alleles with Trypanosoma brucei rhodesiense infection outcomes in the northern part of Malawi. [PDF]
PLoS Negl Trop Dis, 2019 Kamoto K +14 more
europepmc +3 more sources
Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense. [PDF]
Molecules, 2017 Nnadi CO +4 more
europepmc +3 more sources