Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense [PDF]
Int J Mol Sci, 2022 Rhodesain is a cysteine protease that is crucial for the life cycle of Trypanosoma brucei rhodesiense, a parasite causing the lethal form of Human African Trypanosomiasis.
Carla Di Chio +8 more
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Decolonising Parasitology: The Case of Trypanosoma brucei rhodesiense.
Trends in Parasitology, 2021 Trypanosoma brucei rhodesiense was named after Rhodesia which, in turn, was named after the British imperialist and white supremacist Cecil Rhodes. In the light of the Black Lives Matter movement and contemporary consciousness of postcolonial legacy, it seems opportune to reconsider the subspecies name. Pros and cons of renaming T. b.
D. Steverding, K. Tyler
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Trypanosoma brucei rhodesiense [PDF]
Definitions, 2020 This datasheet on Trypanosoma brucei rhodesiense covers Identity.
R. Ringelmann, B. Heym
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Research, Society and Development, 2021 Molecular electrostatic potential (MEP) and pattern recognition (PR) were used to draw potentially active pentamidine derivatives against Trypanosome brucei rhodesiense (T. b. rhodesiense). PR models: Principal Component Analysis, PCA model; Hierarchical
Luã Felipe Souza de Oliveira +11 more
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The Alkaloid-Enriched Fraction of Pachysandra terminalis (Buxaceae) Shows Prominent Activity against Trypanosoma brucei rhodesiense [PDF]
Molecules, 2021 In the course of our studies on antiprotozoal natural products and following our recent discovery that certain aminosteroids and aminocycloartanoid compounds from Holarrhena africana A. DC. (Apocynaceae) and Buxus sempervirens L. (Buxaceae), respectively,
Dagmar Flittner +4 more
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Plasma cytokines quantification among Trypanosoma brucei rhodesiense sleeping sickness cases and controls in Rumphi, Malawi [PDF]
Malawi Med J, 2021 Introduction Trypanosoma brucei (T.b.) rhodesiense is the cause of the acute form of human African trypanosomiasis (HAT) in eastern and southern African countries, including Malawi. For a long time, untreated HAT infections were believed to be 100% fatal.
K. Kamoto +7 more
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Drug Synergism: Studies of Combination of RK-52 and Curcumin against Rhodesain of Trypanosoma brucei rhodesiense. [PDF]
ACS Med Chem Lett, 2020 Rhodesain is an enzyme essential for the life of Trypanosoma brucei rhodesiense, a parasite causing a rapid-onset form of Human African Trypanosomiasis. RK-52 is a synthetic inhibitor of rhodesain, characterized by an impressive k second value (k second =
R. Ettari +6 more
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Phagocytosis of Trypanosoma brucei rhodesiense by peritoneal macrophages: a study by scanning electronmicroscopy [PDF]
Journal of Medical Microbiology, 1983 Phagocytosis of Trypanosoma brucei rhodesiense by peritoneal macrophages takes place by seizure of the trypomastigote by either end but usually by the anterior. A lamellar sheath similar to that seen in phagocytosis of the promastigote of Leishmania is observed, but it is smaller and does not proceed to envelop the living parasite.
M.O. Abolarin, W.E. Ormerod, P M Rowles
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Glutathione Derivatives Active against Trypanosoma brucei rhodesiense and T. brucei brucei In Vitro [PDF]
Antimicrobial Agents and Chemotherapy, 2002 ABSTRACT Diesters based on N -benzyloxycarbonyl- S -(2,4-dinitrophenyl) GSH (CBzGSDNP) containing linear alcohols 3 to 9, branched alcohols 10 to 20, or heteroatom linear alcohols 21 to 25, were investigated as in vitro inhibitors of pathogenic parasites.
Sylvie Daunes, Claudius D’Silva
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The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense. [PDF]
American Journal of Tropical Medicine and Hygiene, 2002 In the search for new diagnostic methods that would distinguish Trypanosoma brucei rhodesiense from T. b. brucei and T. b. gambiense, we have developed two polymerase chain reaction (PCR) primer sets.
Magdalena Radwanska +8 more
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