Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase [PDF]
Antimicrobial Agents and Chemotherapy, 1990 A structural analog, 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxy adenosine (MDL 73811), of decarboxy S-adenosyl-L-methionine, the product of the reaction catalyzed by S-adenosyl-L-methionine (AdoMet) decarboxylase (DC), was found to inhibit Trypanosoma brucei brucei AdoMet DC.
Alan J. Bitonti +7 more
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C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. [PDF]
PLoS Pathogens, 2009 Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T.
Laurence Lecordier +7 more
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Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense [PDF]
Natural Product Research, 2018 Curcumin and genistein are two natural products obtained from Curcuma longa L. and soybeans, endowed with many biological properties. Within the last years they were shown to possess also a promising antitrypanosomal activity.
Roberta Ettari +6 more
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Cell-Mediated Hypersensitivity in Rabbits Infected with Trypanosoma brucei and Trypanosoma rhodesiense [PDF]
Infection and Immunity, 1971 Animals infected with strains of Trypanosoma brucei and T. rhodesiense exhibited cutaneous hypersensitivity to intradermal administration of antigen. This reactivity was of two types, an Arthus-type, antibody-mediated reaction which reached maximum intensity 4 hr after injection and a delayed-
Ian R. Tizard, M. A. Soltys
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PLoS Neglected Tropical Diseases, 2020 Human African Trypanosomiasis (HAT) is a potentially fatal parasitic infection caused by the trypanosome sub-species Trypanosoma brucei gambiense and T. b. rhodesiense transmitted by tsetse flies. Currently, global HAT case numbers are reaching less than
Gala Garrod +5 more
doaj +3 more sources
Artemisinins Inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense In Vitro Growth [PDF]
Antimicrobial Agents and Chemotherapy, 2007 ABSTRACT Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T.
Yuliya V. Mishina +3 more
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Coenzyme Q_10 prevented Trypanosoma brucei rhodesiense-mediated breach of the blood brain barrier, inflammation and organ damage in late stage of Human African Trypanosomiasis [PDF]
J Parasit Dis, 2022 Lynn Kitwan +5 more
semanticscholar +2 more sources
Association of APOL1 renal disease risk alleles with Trypanosoma brucei rhodesiense infection outcomes in the northern part of Malawi [PDF]
PLoS Negl Trop Dis, 2019 Trypanosoma brucei (T.b.) rhodesiense is the cause of the acute form of human African trypanosomiasis (HAT) in eastern and southern African countries. There is some evidence that there is diversity in the disease progression of T.b.
K. Kamoto +11 more
semanticscholar +2 more sources
Trypanosoma brucei rhodesiense infection in a Chinese traveler returning from the Serengeti National Park in Tanzania [PDF]
Infect Dis Poverty, 2018 BackgroundHuman African trypanosomiasis (HAT) is one of the most complex parasitic diseases known to humankind. It usually occurs in endemic areas in Africa, but is occasionally detected in returning travelers and migrants in non-endemic countries.Case ...
Liu Q +10 more
semanticscholar +2 more sources
Mouse experiments demonstrate differential pathogenicity and virulence of Trypanosoma brucei rhodesiense strains [PDF]
Exp Parasitol, 2021 Limo William Kipkorir +6 more
semanticscholar +2 more sources