Results 71 to 80 of about 14,712 (223)

Potential of entomopathogenic fungi for Glossina austeni control: insights into microbiome alterations and implications on sustainable management of the pest

Insect Science, Volume 32, Issue 5, Page 1691-1712, October 2025.
Abstract Glossina austeni Newstead (Diptera: Glossinidae) is a competent vector of the trypanosomes causing human African trypanosomiasis and the African animal trypanosomosis. Management of this pest has primarily involved trapping methods, Sterile Insect Technique, and research into vector competence–symbiotic interactions.
Fidelis Levi Odhiambo Ombura, Imna Malele, Adly MM Abd‐Alla, Komivi Senyo Akutse, Inusa Jacob Ajene, Fathiya Mbarak Khamis   +5 more
wiley   +1 more source

PLS-Prediction and Confirmation of Hydrojuglone Glucoside as the Antitrypanosomal Constituent of Juglans Spp.

Molecules, 2015
Naphthoquinones (NQs) occur naturally in a large variety of plants. Several NQs are highly active against protozoans, amongst them the causative pathogens of neglected tropical diseases such as human African trypanosomiasis (sleeping sickness), Chagas ...
Therese Ellendorff, Reto Brun, Marcel Kaiser, Jandirk Sendker, Thomas J. Schmidt   +4 more
doaj   +1 more source

Through the dark continent: African trypanosome development in the tsetse fly [PDF]

, 2013
African trypanosomes are unicellular flagellated parasites causing trypanosomiases in Africa, a group of severe diseases also known as sleeping sickness in human and nagana in cattle.
Rotureau, Brice, Van Den Abbeele, Jan
core   +4 more sources

Glutathione Derivatives Active against Trypanosoma brucei rhodesiense and T. brucei brucei In Vitro [PDF]

Antimicrobial Agents and Chemotherapy, 2002
ABSTRACT Diesters based on N -benzyloxycarbonyl- S -(2,4-dinitrophenyl) GSH (CBzGSDNP) containing linear alcohols 3 to 9, branched alcohols 10 to 20, or heteroatom linear alcohols 21 to 25, were investigated as in vitro inhibitors of pathogenic parasites.
Sylvie, Daunes, Claudius, D'Silva
openaire   +2 more sources

Spiroplasma infection in colonized Glossina fuscipes fuscipes: impact on mass rearing and the sterile insect technique

Insect Science, Volume 32, Issue 5, Page 1761-1776, October 2025.
Abstract Tsetse flies (Glossina spp.) can vector the parasites (Trypanosoma spp.) that cause the socioeconomically devastating neglected tropical diseases human and animal African trypanosomoses. In addition to this parasite, tsetse can harbor four genera of endosymbiotic bacteria, including Wigglesworthia, Sodalis, Wolbachia, and Spiroplasma, which ...
Kiswend‐sida M. Dera, Daouda Tande Barro, Bénéwendé Aristide Kaboré, Fabian Gstöttenmayer, Mouhamadou M. Dieng, Soumaïla Pagabeleguem, Brian L. Weiss, Giulia Fiorenza, Riccardo Piccinno, Anna R. Malacrida, Serap Aksoy, Chantel J. de Beer, Robert L. Mach, Marc J. B. Vreysen, Adly M. M. Abd‐Alla   +14 more
wiley   +1 more source

Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1. [PDF]

PLoS Pathogens, 2018
In contrast to Trypanosoma brucei gambiense and T. b. rhodesiense (the causative agents of human African trypanosomiasis), T. b. brucei is lysed by apolipoprotein-L1 (apoL1)-containing human serum trypanolytic factors (TLF), rendering it non-infectious ...
Rachel B Currier, Anneli Cooper, Hollie Burrell-Saward, Annette MacLeod, Sam Alsford   +4 more
doaj   +1 more source

A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome [PDF]

, 2014
<i>Trypanosoma brucei</i> is the causative agent of African sleeping sickness in humans and one of several pathogens that cause the related veterinary disease Nagana.
Capewell, Paul, Clucas, Caroline, Cooper, Anneli, MacLeod, Annette, Weir, William   +4 more
core   +1 more source

New tsetse (Glossina fuscipes fuscipes) genomes generated from wild and laboratory‐reared specimens

Insect Science, Volume 32, Issue 5, Page 1588-1596, October 2025.
Abstract Tsetse (Glossina spp.) are vectors of African trypanosomes that cause devastating human and animal African trypanosomiases. While much of the research to better understand tsetse genetics and physiology relies on colony‐reared flies, these flies may not represent the genetic diversity found in natural wild populations due to their long‐term ...
Daniel J. Bruzzese, Brian L. Weiss, Richard Echodu, Paul O. Mireji, Adly M.M Abd‐Alla, Serap Aksoy   +5 more
wiley   +1 more source

Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection

mBio, 2016
African trypanosomes, except Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, which cause human African trypanosomiasis, are lysed by the human serum protein apolipoprotein L1 (ApoL1).
Bart Cuypers, Laurence Lecordier, Conor J. Meehan, Frederik Van den Broeck, Hideo Imamura, Philippe Büscher, Jean-Claude Dujardin, Kris Laukens, Achim Schnaufer, Caroline Dewar, Michael Lewis, Oliver Balmer, Thomas Azurago, Sardick Kyei-Faried, Sally-Ann Ohene, Boateng Duah, Prince Homiah, Ebenezer Kofi Mensah, Francis Anleah, Jose Ramon Franco, Etienne Pays, Stijn Deborggraeve   +21 more
doaj   +1 more source

In Vitro Leishmanicidal Efficacy of Synthesized Arylidene Analogues of Glitazone

Drug Development Research, Volume 86, Issue 5, August 2025.
ABSTRACT Diabetes is a fast‐growing health issue in low‐ and middle‐income countries, with ~80% of diabetics living in the tropics and sub‐tropics. It is a deadly condition claiming the lives of millions of individuals annually, with no therapeutic treatment available to date. The management of diabetes is thus limited to symptomatic relief by glycemic
Janine Aucamp, Helena D. Janse van Rensburg, Simon S. Mnyakeni‐Moleele, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source