Results 81 to 90 of about 28,049 (192)
Parasites & Vectors, 2019 African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa.
Mathieu Cayla +4 more
doaj +1 more source
Tropical Medicine and Infectious Disease, 2020 Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs.
Srinivasa P S Rao +13 more
doaj +1 more source
Weaving knowledges to support wildlife health surveillance in Kenya's pastoral rangelands
Conservation Biology, Volume 40, Issue 1, February 2026.Abstract In wildlife–livestock–human interfaces, pathogens capable of spreading between wild and domestic animals and humans have important implications for conservation outcomes, economics, and public health. Robust wildlife health surveillance can help address these risks.
Brock Bersaglio +4 more
wiley +1 more source
Anilinoquinoline based inhibitors of trypanosomatid proliferation.
PLoS Neglected Tropical Diseases, 2018 We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum.
Lori Ferrins +11 more
doaj +1 more source
The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa
The FEBS Journal, Volume 293, Issue 4, Page 948-958, February 2026.Metacaspases are Ca2+‐dependent cysteine proteases whose structural characteristics, particularly calcium binding and autocatalytic processing, govern their activation and biological functions. These enzymes differ among microorganisms and regulate their cell cycles, making them excellent targets for drug development.
Ane C. M. Duarte +9 more
wiley +1 more source
Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune system [PDF]
, 2020 Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Magez, Stefan +3 more
core +1 more source
Artificial intelligence‐powered microscopy: Transforming the landscape of parasitology
Journal of Microscopy, Volume 301, Issue 2, Page 280-329, February 2026.Abstract Microscopy and image analysis play a vital role in parasitology research; they are critical for identifying parasitic organisms and elucidating their complex life cycles. Despite major advancements in imaging and analysis, several challenges remain. These include the integration of interdisciplinary data; information derived from various model
Mariana De Niz +4 more
wiley +1 more source
A murine model of Trypanosoma brucei-induced myocarditis and cardiac dysfunction
Microbiology SpectrumTrypanosoma brucei is a protozoan parasite that causes human and animal African trypanosomiases (HAT and AAT). Cardiac symptoms are commonly reported in HAT patients, and intracardiac parasites with accompanying myocarditis have been observed in both ...
Nathan P. Crilly +7 more
doaj +1 more source
Pharmacological Approaches to Antitrypanosomal Chemotherapy
Memorias do Instituto Oswaldo Cruz, 1999 There is an urgent need for new drugs for the chemotherapy of human African trypanosomiasis, Chagas disease and leishmaniasis. Progress has been made in the identification and characterization of novel drug targets for rational chemotherapy and ...
Simon L Croft
doaj +1 more source