Tryptase and tumor angiogenesis [PDF]
Frontiers in OncologyTryptases represent the most abundant constituent of human mast cells, involved in extracellular matrix degradation, contributing to wound healing and metastasis. Moreover, most recently, it has been demonstrated that tryptase is angiogenic both in vitro
Domenico Ribatti
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Changes in tryptase levels during cardiac surgery in patients at low risk for allergic reactions
Medičnì Perspektivi, 2022 Tryptase test can be used as a clinical marker of mast cell activation. The present study is was aimed to identify variations in serum tryptase levels and their possible relationships with allergic reactions to protamine in low-risk patients undergoing ...
Menekse Oksar +5 more
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PLoS ONE, 2021 Ruminants have a very complex digestive system adapted for the digestion of cellulose rich food. Gene duplications have been central in the process of adapting their digestive system for this complex food source.
Zhirong Fu +8 more
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Brazilian Oral Research, 2021 : Inflammatory periapical lesions are characterized by infiltration of different immune cell types, the functions of which depend on an effective vascular network. This study aimed to evaluate the mast cells density (MCD) in inflamatory odontogenic cysts
Hugo Costa Neto +4 more
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Adult mastocytosis: a review of the Santo António Hospital 's experience and an evaluation of World Health Organization criteria for the diagnosis of systemic disease [PDF]
Anais Brasileiros de Dermatologia, 2014 BACKGROUND: Mastocytosis is a clonal disorder characterized by the accumulation of abnormal mast cells in the skin and/or in extracutaneous organs. OBJECTIVES: To present all cases of mastocytosis seen in the Porto Hospital Center and evaluate the ...
Iolanda Conde Fernandes +5 more
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Generation of a new congenic mouse strain with enhanced chymase expression in mast cells. [PDF]
PLoS ONE, 2013 Mast cells are effector cells best known for their roles in IgE-associated allergy, but they also play a protective role in defense against pathogens. These cells express high levels of proteases including chymase, tryptase and carboxypeptidase.
Xi Jin +4 more
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Implantation serine proteinase 1 exhibits mixed substrate specificity that silences signaling via proteinase-activated receptors. [PDF]
PLoS ONE, 2011 Implantation S1 family serine proteinases (ISPs) are tryptases involved in embryo hatching and uterine implantation in the mouse. The two different ISP proteins (ISP1 and ISP2) have been detected in both pre- and post-implantation embryo tissue. To date,
Navneet Sharma +8 more
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Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge
Nature Communications, 2020 β-tryptases are responsible for most of the proteolytic activity during mast cell activation. Here, the authors develop β-tryptase-inhibiting antibodies and provide structural and biochemical evidence that the bivalency of the antibodies is a ...
Henry R. Maun +17 more
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A simple, sensitive and safe method to determine the human α/β-tryptase genotype. [PDF]
PLoS ONE, 2014 The human tryptase locus on chromosome 16 contains one gene encoding only β-tryptase and another encoding either β-tryptase or the homologous α-tryptase, providing α:β gene ratios of 0:4, 1:3 or 2:2 in the diploid genome, these genotypes being of ...
Quang Trong Le +3 more
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Expression of mast cell proteases correlates with mast cell maturation and angiogenesis during tumor progression. [PDF]
PLoS ONE, 2012 Tumor cells are surrounded by infiltrating inflammatory cells, such as lymphocytes, neutrophils, macrophages, and mast cells. A body of evidence indicates that mast cells are associated with various types of tumors.
Devandir Antonio de Souza +5 more
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