Results 1 to 10 of about 222,637 (336)

Systemic tryptophan homeostasis

Frontiers in Molecular Biosciences, 2022
Tryptophan is an essential amino acid, which is not only a building block for protein synthesis, but also a precursor for the biosynthesis of co-enzymes and neuromodulators, such as NAD/NADP(H), kynurenic acid, melatonin and serotonin.
Simon Klaessens, Simon Klaessens, Vincent Stroobant, Vincent Stroobant, Etienne De Plaen, Etienne De Plaen, Benoit J. Van den Eynde, Benoit J. Van den Eynde, Benoit J. Van den Eynde, Benoit J. Van den Eynde   +9 more
doaj   +4 more sources

ON THE EMISSION OF TRYPTOPHAN [PDF]

Proceedings of the National Academy of Sciences, 1958
Irvin Isenberg, Albert Szent‐Györgyi
openalex   +5 more sources

Immunomodulatory, behavioral, and nutritional response of tryptophan application on poultry [PDF]

Veterinary World, 2021
Tryptophan is an essential amino acid for all animals that was discovered through casein hydrolysis. The use of tryptophan as feed additives has been attracting the attention of many nutritionists because it cannot be synthesized enough in an animal's ...
Nguyen Thuy Linh, Budi Guntoro, Nguyen Hoang Qui   +2 more
doaj   +1 more source

Effect of Varying Levels of Dietary Tryptophan on Aggression and Abnormal Behavior in Growing Pigs

Frontiers in Veterinary Science, 2022
Body lesions, resulting from tail-biting and ear-biting, can result in decreased health and welfare in pigs. Tryptophan, an indispensable amino acid, is needed to support protein deposition, and the synthesis of the neurotransmitter serotonin, which is ...
Maggie Henry, Anna Kate Shoveller, Terri L. O'Sullivan, Lee Niel, Robert Friendship   +4 more
doaj   +1 more source

Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation

Journal for ImmunoTherapy of Cancer, 2021
Background Tryptophan catabolites suppress immunity. Therefore, blocking tryptophan catabolism with indoleamine 2,3-dioxygenase (IDO) inhibitors is pursued as an anticancer strategy.Methods The intracellular level of tryptophan and kynurenine was ...
Yan Huang, Wei Xu, Chen Zhao, Yan Lin, Yao Li, Rui Qin, Chen-Ji Wang, Jian-Yuan Zhao, Yi-Yuan Yuan, Peng-Cheng Lin, Shimin Zhao   +10 more
doaj   +1 more source

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Nature, 2022
AbstractActivated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme1–4. Here we show that despite tryptophan depletion, in-frame protein synthesis continues across tryptophan codons.
Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos, Justine Michaux, Hui Song Pak, Onno B. Bleijerveld, Kelly Mordente, Jasmine Montenegro Navarro, Naomi Blommaert, Morten M. Nielsen, Domenica Lovecchio, Everett Stone, George Georgiou, Mark C. de Gooijer, Olaf van Tellingen, Maarten Altelaar, Robbie P. Joosten, Anastassis Perrakis, Johanna Olweus, Michal Bassani-Sternberg, Daniel S. Peeper, Reuven Agami   +23 more
openaire   +8 more sources

Determination of tryptophan in milk

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького. Серія: Харчові технології, 2023
Tryptophan or L-tryptophan is one of the essential amino acids for the human body. An important component of the human diet, L-tryptophan is not only involved in protein synthesis in the body, but is also crucial for a number of metabolic functions.
N. P. Kvitkovskaya, V. M. Ischenko, O. V. Kochubei-Lytvynenko, M. V. Ischenko   +3 more
doaj   +1 more source

Supplementary Tryptophan Fed to Sows Prior to and after Farrowing to Improve Piglet Growth and Survival

Animals, 2021
Tryptophan indirectly increases plasma calcium levels, which may improve sow health, and melatonin production, which may improve piglet survival when supplemented during late gestation and lactation.
Amy L. Munn, Alice C. Weaver, William H. E. J. van Wettere   +2 more
doaj   +1 more source

AhR/IL-22 pathway as new target for the treatment of post-infectious irritable bowel syndrome symptoms

Gut Microbes, 2022
Alterations in brain/gut/microbiota axis are linked to Irritable Bowel Syndrome (IBS) physiopathology. Upon gastrointestinal infection, chronic abdominal pain and anxio-depressive comorbidities may persist despite pathogen clearance leading to Post ...
Maëva Meynier, Elodie Baudu, Nathalie Rolhion, Manon Defaye, Marjolène Straube, Valentine Daugey, Morgane Modoux, Ivan Wawrzyniak, Frédéric Delbac, Romain Villéger, Mathieu Méleine, Esther Borras Nogues, Catherine Godfraind, Nicolas Barnich, Denis Ardid, Philippe Poirier, Harry Sokol, Jean-Marc Chatel, Philippe Langella, Valérie Livrelli, Mathilde Bonnet, Frédéric Antonio Carvalho   +21 more
doaj   +1 more source

Ultraviolet Nanophotonics Enables Autofluorescence Correlation Spectroscopy on Label-Free Proteins With a Single Tryptophan [PDF]

, 2023
Using the ultraviolet autofluorescence of tryptophan aminoacids offers fascinating perspectives to study single proteins without the drawbacks of fluorescence labelling. However, the low autofluorescence signals have so far limited the UV detection to large proteins containing several tens of tryptophan residues.
arxiv   +1 more source