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Immunomodulatory, behavioral, and nutritional response of tryptophan application on poultry [PDF]

Veterinary World, 2021
Tryptophan is an essential amino acid for all animals that was discovered through casein hydrolysis. The use of tryptophan as feed additives has been attracting the attention of many nutritionists because it cannot be synthesized enough in an animal's ...
Nguyen Thuy Linh, Budi Guntoro, Nguyen Hoang Qui   +2 more
doaj   +1 more source

Effect of Varying Levels of Dietary Tryptophan on Aggression and Abnormal Behavior in Growing Pigs

Frontiers in Veterinary Science, 2022
Body lesions, resulting from tail-biting and ear-biting, can result in decreased health and welfare in pigs. Tryptophan, an indispensable amino acid, is needed to support protein deposition, and the synthesis of the neurotransmitter serotonin, which is ...
Maggie Henry, Anna Kate Shoveller, Terri L. O'Sullivan, Lee Niel, Robert Friendship   +4 more
doaj   +1 more source

Systemic tryptophan homeostasis

Frontiers in Molecular Biosciences, 2022
Tryptophan is an essential amino acid, which is not only a building block for protein synthesis, but also a precursor for the biosynthesis of co-enzymes and neuromodulators, such as NAD/NADP(H), kynurenic acid, melatonin and serotonin.
Simon Klaessens, Simon Klaessens, Vincent Stroobant, Vincent Stroobant, Etienne De Plaen, Etienne De Plaen, Benoit J. Van den Eynde, Benoit J. Van den Eynde, Benoit J. Van den Eynde, Benoit J. Van den Eynde   +9 more
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Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation

Journal for ImmunoTherapy of Cancer, 2021
Background Tryptophan catabolites suppress immunity. Therefore, blocking tryptophan catabolism with indoleamine 2,3-dioxygenase (IDO) inhibitors is pursued as an anticancer strategy.Methods The intracellular level of tryptophan and kynurenine was ...
Yan Huang, Wei Xu, Chen Zhao, Yan Lin, Yao Li, Rui Qin, Chen-Ji Wang, Jian-Yuan Zhao, Yi-Yuan Yuan, Peng-Cheng Lin, Shimin Zhao   +10 more
doaj   +1 more source

Disruption of GPR35 Signaling in Bone Marrow-Derived Cells Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice

Metabolites, 2021
G-protein-coupled receptor-35 (GPR35) has been identified as a receptor for the tryptophan metabolite kynurenic acid (KynA) and suggested to modulate macrophage polarization in metabolic tissues.
Roland Baumgartner, Felipe B. Casagrande, Randi B. Mikkelsen, Martin Berg, Konstantinos A. Polyzos, Maria J. Forteza, Aastha Arora, Thue W. Schwartz, Siv A. Hjorth, Daniel F. J. Ketelhuth   +9 more
doaj   +1 more source

Glycated Tryptophan in the Plasma of Chickens Fed Tryptophan-excess Diets

The Journal of Poultry Science, 2015
When tryptophan is glycated with glucose, it results in forming two types of glycated tryptophan, glucose-tryptophan Amadori product and (1R, 3S)-1-(D- gluco-1,2,3,4,5-pentahydroxypentyl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (PHP-THβC ...
Ryosuke Makino, Yoshimi Kawashima, Yuki Kajita, Toshiharu Namauo, Satoshi Ogawa, Hiroki Muraoka, Shinobu Fujimura, Kazumi Kita   +7 more
doaj   +1 more source

Detection of Two Types of Glycated Tryptophan Compounds in the Plasma of Chickens Fed Tryptophan Excess Diets

The Journal of Poultry Science, 2013
When tryptophan is glycated with glucose, it results in forming two types of glycated tryptophan compounds, glucose-tryptophan Amadori product and (1R, 3S)-1-(D-gluco-1,2,3,4,5-pentahydroxypentyl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (PHP ...
Kazumi Kita, Yoshimi Kawashima, Ryosuke Makino, Toshiharu Namauo, Satoshi Ogawa, Hiroki Muraoka, Shinobu Fujimura   +6 more
doaj   +1 more source

Memory Enhancement with Kynurenic Acid and Its Mechanisms in Neurotransmission

Biomedicines, 2022
Kynurenic acid (KYNA) is an endogenous tryptophan (Trp) metabolite known to possess neuroprotective property. KYNA plays critical roles in nociception, neurodegeneration, and neuroinflammation.
Diána Martos, Bernadett Tuka, Masaru Tanaka, László Vécsei, Gyula Telegdy   +4 more
doaj   +1 more source

One-step of tryptophan attenuator inactivation and promoter swapping to improve the production of L-tryptophan in Escherichia coli

Microbial Cell Factories, 2012
Background L-tryptophan is an aromatic amino acid widely used in the food, chemical and pharmaceutical industries. In Escherichia coli, L-tryptophan is synthesized from phosphoenolpyruvate and erythrose 4-phosphate by enzymes in the shikimate pathway and
Gu Pengfei, Yang Fan, Kang Junhua, Wang Qian, Qi Qingsheng   +4 more
doaj   +1 more source

Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle.

PLoS Biology, 2007
Mammalian cells rely on cellular uptake of the essential amino acid tryptophan. Tryptophan sequestration by up-regulation of the key enzyme for tryptophan degradation, indoleamine 2,3-dioxygenase (IDO), e.g., in cancer and inflammation, is thought to ...
Thijs Kaper, Loren L Looger, Hitomi Takanaga, Michael Platten, Lawrence Steinman, Wolf B Frommer   +5 more
doaj   +1 more source