Results 1 to 10 of about 187,096 (216)

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Nature, 2022
AbstractActivated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme1–4. Here we show that despite tryptophan depletion, in-frame protein synthesis continues across tryptophan codons.
Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos, Justine Michaux, Hui Song Pak, Onno B. Bleijerveld, Kelly Mordente, Jasmine Montenegro Navarro, Naomi Blommaert, Morten M. Nielsen, Domenica Lovecchio, Everett Stone, George Georgiou, Mark C. de Gooijer, Olaf van Tellingen, Maarten Altelaar, Robbie P. Joosten, Anastassis Perrakis, Johanna Olweus, Michal Bassani-Sternberg, Daniel S. Peeper, Reuven Agami   +23 more
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Tryptophan to Tryptophan Hole Hopping in an Azurin Construct

The Journal of Physical Chemistry B, 2023
Electron transfer (ET) between neutral and cationic tryptophan residues in the azurin construct [ReI(H126)(CO)3(dmp)](W124)(W122)CuI (dmp = 4,7-Me2-1,10-phenanthroline) was investigated by Born-Oppenheimer quantum-mechanics/molecular mechanics/molecular dynamics (QM/MM/MD) simulations.
Martin Melčák, Filip Šebesta, Jan Heyda, Harry B. Gray, Stanislav Záliš, Antonín Vlček   +5 more
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Tryptophan and depression

The Lancet, 1997
Correspondence
BARBUI, Corrado, Garattini S.
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Interactions of Tryptophan, Tryptophan Peptides, and Tryptophan Alkyl Esters at Curved Membrane Interfaces [PDF]

Biochemistry, 2006
Motivated by ongoing efforts to understand the mechanism of membrane protein crystallogenesis and transport in the lipidic cubic phase, the nature of the interaction between tryptophan and the bilayer/aqueous interface of the cubic phase has been investigated.
Martin Caffrey, Wei Liu
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Systemic tryptophan homeostasis

Frontiers in Molecular Biosciences, 2022
Tryptophan is an essential amino acid, which is not only a building block for protein synthesis, but also a precursor for the biosynthesis of co-enzymes and neuromodulators, such as NAD/NADP(H), kynurenic acid, melatonin and serotonin. It also plays a role in immune homeostasis, as local tryptophan catabolism impairs T-lymphocyte mediated immunity ...
Simon Klaessens, Simon Klaessens, Vincent Stroobant, Vincent Stroobant, Etienne De Plaen, Etienne De Plaen, Benoit J. Van den Eynde, Benoit J. Van den Eynde, Benoit J. Van den Eynde, Benoit J. Van den Eynde   +9 more
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Tryptophan in Nutrition and Health

International Journal of Molecular Sciences, 2022
Tryptophan is a rate-limiting essential amino acid and a unique building block of peptides and proteins [...]
Poeggeler, Burkhard, Singh, Sandeep Kumar, Pappolla, Miguel A., Poeggeler, Burkhard; 1Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, Faculty of Biology and Psychology, Georg-August-University of Göttingen, Am Türmchen 3, 33332 Gütersloh, Germany, Singh, Sandeep Kumar; 2Indian Scientific Education and Technology Foundation, Lucknow 226002, India; sandeeps.bhu@gmail.com, Pappolla, Miguel A.; 3Department of Neurology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA; pappolla@aol.com   +5 more
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Tryptophan catabolism by tryptophan pyrrolase in rat liver. The effect of tryptophan loads and changes in tryptophan pyrrolase activity.

Journal of Biological Chemistry, 1975
We investigated how changes in tryptophan pyrrolase activity and tryptophan loads affect the breakdown of tryptophan was estimated by injecting rats with [ring-2-14-C]tryptophan and measuring respiratory 14-CO2. We concluded, contrary to previous reports, that induction of tryptophan pyrrolase definitely will increase the rate of tryptophan breakdown ...
S N Young, T L Sourkes
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ROTATIONAL SPECTRUM OF TRYPTOPHAN [PDF]

Proceedings of the 69th International Symposium on Molecular Spectroscopy, 2014
The rotational spectrum of the natural amino acid tryptophan has been observed for the first time using a combination of laser ablation, molecular beams, and Fourier transform microwave spectroscopy. Independent analysis of the rotational spectra of individual conformers has conducted to a definitive identification of two different conformers of ...
Sanz, Maria Eugenia, Cabezas, Carlos, Mata, Santiago, Alonso, Josè L   +3 more
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Tryptophan Catabolites and Migraine [PDF]

Current Pharmaceutical Design, 2016
Migraine is a highly disabling neurological condition affecting around 15% of the population worldwide. Decades of intensive research shed some light on diseases pathomechanism, but information is still missing about the initiation of the attack. In the past century, serotonin emerged as the main target of both basic and therapeutic research.
Bohár Zsuzsanna, Párdutz Árpád, Vécsei László   +2 more
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Tryptophan Metabolism in Alcoholism [PDF]

Nutrition Research Reviews, 1999
Studies of tryptophan (Trp) metabolism in relation to the serotonin status in alcoholism are of 2 types: (1) those related to the pharmacological effects of ethanol; (2) those concerning the serotonin status in the absence of alcohol intake. In experimental animals, acute and chronic ethanol administration and subsequent withdrawal exert a variety of ...
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