Results 111 to 120 of about 187,096 (216)

Tryptophan-Derived Metabolites and Glutamate Dynamics in Fatal Insulin Poisoning: Mendelian Randomization of Human Cohorts and Experimental Validation in Rat Models. [PDF]

Int J Mol Sci
Yuan Y, Liu Y, Wang S, Zhang J, Gao X, Li Y, Yu Z, Zhou Y.   +7 more
europepmc   +1 more source

TRYPTOPHAN, OXYGEN, AND SLEEP [PDF]

Annual Review of Biochemistry, 1994
openaire   +3 more sources

Advances in Cytosolic Delivery of Proteins: Approaches, Challenges, and Emerging Technologies

Chemistry &Biodiversity, EarlyView.
Proteins regulate almost all biological processes, and overcoming the protein's natural membrane inpermeability will provide a unique opportunity for intracellular targeting of related therapeutic proteins. Chemical modification of proteins and different types of delivery vectors can mediate intracellular transport of proteins, providing new ideas for ...
Wenyan Zhang, Huiling Liu, Bingdong Zhu, Wen Li, Xue Han, Jiaojiao Fu, Renjie Luo, Haiyan Wang, Jinxia Wang   +8 more
wiley   +1 more source

ALE reveals a surprising link between [Fe-S] cluster formation, tryptophan biosynthesis and the potential regulatory protein TrpP in Corynebacterium glutamicum. [PDF]

BMC Microbiol
Zuchowski R, Schito S, Mack C, Wirtz A, Bott M, Polen T, Noack S, Baumgart M.   +7 more
europepmc   +1 more source

Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition

Chemistry &Biodiversity, EarlyView.
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Morkoss M. Fakhry, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source

Untargeted metabolomics reveals key metabolic alterations in pediatric epilepsy with insights into Tryptophan metabolism and the gut-brain axis. [PDF]

Sci Rep
Chojnowski K, Opiełka M, Urbanowicz K, Zawadzka M, Wangin K, Smoleński RT, Mazurkiewicz-Bełdzińska M.   +6 more
europepmc   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Plasma levels of immune system activation markers Neopterin and Kynurenine-to-Tryptophan Ratio, and oral health among community-dwelling adults in Norway: a population-based, cohort study. [PDF]

Acta Odontol Scand
Banjara S, Berggreen E, Igland J, Åstrøm AK, Midttun Ø, Bunæs D, Sulo G.   +6 more
europepmc   +1 more source

Boron‐Based Functionalities Enhance the Potency of 2,5‐Dimethylfuran‐Based IDO1 Inhibitors

ChemBioChem, EarlyView.
Indoleamine‐2,3‐dioxygenase‐1 (IDO1), a key immunoregulatory enzyme, is inhibited by novel boron derivatives (closo‐1,2‐ and 1,7‐carborane, boronic acids and esters, and benzoxaboroles) of 2,5‐dimethylfuran, each displaying low μM affinity for the human recombinant enzyme.
Thomas J. C. Carraro, Samrat Dasgupta, Jacqueline Ku, Shane R. Thomas, Louis M. Rendina   +4 more
wiley   +1 more source