Results 11 to 20 of about 222,637 (336)
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls+9 more
wiley +1 more source
Indoleamine 2, 3-dioxygenase 1 inhibitory compounds from natural sources
L-tryptophan metabolism is involved in the regulation of many important physiological processes, such as, immune response, inflammation, and neuronal function.
Ying Tan+4 more
doaj +1 more source
Biochemical and physicochemical indicators of the quality of milk and meat obtained from cows with brucellosis [PDF]
Background and Aim: Brucellosis is a disease occurring worldwide. Although it is mainly a cattle disease, it is extremely dangerous for humans. Milk and meat can be contaminated with Brucella.
Valeriy Alexandrovich Agoltsov+4 more
doaj +1 more source
Ulcerative colitis (UC) is a chronic and recurrent inflammatory disorder in the gastrointestinal tract. Here, we examined the pharmacological effects of ginsenoside Rg1, a natural compound with low bioavailability, on the acute experimental colitis mice ...
Hao Cheng+9 more
doaj +1 more source
Glycated Tryptophan in the Plasma of Chickens Fed Tryptophan-excess Diets
When tryptophan is glycated with glucose, it results in forming two types of glycated tryptophan, glucose-tryptophan Amadori product and (1R, 3S)-1-(D- gluco-1,2,3,4,5-pentahydroxypentyl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (PHP-THβC ...
Ryosuke Makino+7 more
doaj +1 more source
Ultraviolet superradiance from mega-networks of tryptophan in biological architectures [PDF]
Networks of tryptophan -- an aromatic amino acid with strong fluorescent response -- are ubiquitous in biological systems, forming diverse architectures in transmembrane proteins, cytoskeletal filaments, sub-neuronal elements, photoreceptor complexes, virion capsids, and other cellular structures.
arxiv +1 more source
PurposeCardiovascular events and coronary plaque vulnerability are linked to Type D personality. However, the fundamental mechanism has not been clarified.
Yini Wang+10 more
doaj +1 more source
Tryptophan to Tryptophan Hole Hopping in an Azurin Construct
Electron transfer (ET) between neutral and cationic tryptophan residues in the azurin construct [ReI(H126)(CO)3(dmp)](W124)(W122)CuI (dmp = 4,7-Me2-1,10-phenanthroline) was investigated by Born-Oppenheimer quantum-mechanics/molecular mechanics/molecular dynamics (QM/MM/MD) simulations.
Martin Melčák+5 more
openaire +4 more sources
When tryptophan is glycated with glucose, it results in forming two types of glycated tryptophan compounds, glucose-tryptophan Amadori product and (1R, 3S)-1-(D-gluco-1,2,3,4,5-pentahydroxypentyl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (PHP ...
Kazumi Kita+6 more
doaj +1 more source
States of quinolinic acid excess in urine: A systematic review of human studies
IntroductionQuinolinic acid is an intermediate compound derived from the metabolism of dietary tryptophan. Its accumulation has been reported in patients suffering a broad spectrum of diseases and conditions. In this manuscript, we present the results of
Marie Christelle Saade+4 more
doaj +1 more source