Results 11 to 20 of about 229,751 (309)

ON THE EMISSION OF TRYPTOPHAN [PDF]

Proceedings of the National Academy of Sciences, 1958
Irvin Isenberg, Albert Szent‐Györgyi
openalex   +5 more sources

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Nature, 2022
AbstractActivated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme1–4. Here we show that despite tryptophan depletion, in-frame protein synthesis continues across tryptophan codons.
Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos, Justine Michaux, Hui Song Pak, Onno B. Bleijerveld, Kelly Mordente, Jasmine Montenegro Navarro, Naomi Blommaert, Morten M. Nielsen, Domenica Lovecchio, Everett Stone, George Georgiou, Mark C. de Gooijer, Olaf van Tellingen, Maarten Altelaar, Robbie P. Joosten, Anastassis Perrakis, Johanna Olweus, Michal Bassani-Sternberg, Daniel S. Peeper, Reuven Agami   +23 more
openaire   +8 more sources

Glycated Tryptophan in the Plasma of Chickens Fed Tryptophan-excess Diets

The Journal of Poultry Science, 2015
When tryptophan is glycated with glucose, it results in forming two types of glycated tryptophan, glucose-tryptophan Amadori product and (1R, 3S)-1-(D- gluco-1,2,3,4,5-pentahydroxypentyl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (PHP-THβC ...
Ryosuke Makino, Yoshimi Kawashima, Yuki Kajita, Toshiharu Namauo, Satoshi Ogawa, Hiroki Muraoka, Shinobu Fujimura, Kazumi Kita   +7 more
doaj   +1 more source

Tryptophan to Tryptophan Hole Hopping in an Azurin Construct

The Journal of Physical Chemistry B, 2023
Electron transfer (ET) between neutral and cationic tryptophan residues in the azurin construct [ReI(H126)(CO)3(dmp)](W124)(W122)CuI (dmp = 4,7-Me2-1,10-phenanthroline) was investigated by Born-Oppenheimer quantum-mechanics/molecular mechanics/molecular dynamics (QM/MM/MD) simulations.
Martin Melčák, Filip Šebesta, Jan Heyda, Harry B. Gray, Stanislav Záliš, Antonín Vlček   +5 more
openaire   +4 more sources

Detection of Two Types of Glycated Tryptophan Compounds in the Plasma of Chickens Fed Tryptophan Excess Diets

The Journal of Poultry Science, 2013
When tryptophan is glycated with glucose, it results in forming two types of glycated tryptophan compounds, glucose-tryptophan Amadori product and (1R, 3S)-1-(D-gluco-1,2,3,4,5-pentahydroxypentyl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (PHP ...
Kazumi Kita, Yoshimi Kawashima, Ryosuke Makino, Toshiharu Namauo, Satoshi Ogawa, Hiroki Muraoka, Shinobu Fujimura   +6 more
doaj   +1 more source

Tryptophan and depression

The Lancet, 1997
Correspondence
BARBUI, Corrado, Garattini S.
openaire   +2 more sources

Interactions of Tryptophan, Tryptophan Peptides, and Tryptophan Alkyl Esters at Curved Membrane Interfaces [PDF]

Biochemistry, 2006
Motivated by ongoing efforts to understand the mechanism of membrane protein crystallogenesis and transport in the lipidic cubic phase, the nature of the interaction between tryptophan and the bilayer/aqueous interface of the cubic phase has been investigated.
Martin Caffrey, Wei Liu
openaire   +5 more sources

Ginsenoside Rg1 Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Microbial Tryptophan Metabolism

Frontiers in Immunology, 2022
Ulcerative colitis (UC) is a chronic and recurrent inflammatory disorder in the gastrointestinal tract. Here, we examined the pharmacological effects of ginsenoside Rg1, a natural compound with low bioavailability, on the acute experimental colitis mice ...
Hao Cheng, Juan Liu, Dandan Zhang, Jing Wang, Yuzhu Tan, Yuzhu Tan, Wuwen Feng, Wuwen Feng, Cheng Peng, Cheng Peng   +9 more
doaj   +1 more source

One-step of tryptophan attenuator inactivation and promoter swapping to improve the production of L-tryptophan in Escherichia coli

Microbial Cell Factories, 2012
Background L-tryptophan is an aromatic amino acid widely used in the food, chemical and pharmaceutical industries. In Escherichia coli, L-tryptophan is synthesized from phosphoenolpyruvate and erythrose 4-phosphate by enzymes in the shikimate pathway and
Gu Pengfei, Yang Fan, Kang Junhua, Wang Qian, Qi Qingsheng   +4 more
doaj   +1 more source

Indoleamine 2, 3-dioxygenase 1 inhibitory compounds from natural sources

Frontiers in Pharmacology, 2022
L-tryptophan metabolism is involved in the regulation of many important physiological processes, such as, immune response, inflammation, and neuronal function.
Ying Tan, Miaomiao Liu, Ming Li, Yujuan Chen, Meng Ren   +4 more
doaj   +1 more source