Results 21 to 30 of about 504,978 (306)

Tryptophan Metabolism in Depression: A Narrative Review with a Focus on Serotonin and Kynurenine Pathways

International Journal of Molecular Sciences, 2022
Depression is a common and serious disorder, characterized by symptoms like anhedonia, lack of energy, sad mood, low appetite, and sleep disturbances.
A. Correia, N. Vale
semanticscholar   +1 more source

Disruption of GPR35 Signaling in Bone Marrow-Derived Cells Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice

Metabolites, 2021
G-protein-coupled receptor-35 (GPR35) has been identified as a receptor for the tryptophan metabolite kynurenic acid (KynA) and suggested to modulate macrophage polarization in metabolic tissues.
Roland Baumgartner, Felipe B. Casagrande, Randi B. Mikkelsen, Martin Berg, Konstantinos A. Polyzos, Maria J. Forteza, Aastha Arora, Thue W. Schwartz, Siv A. Hjorth, Daniel F. J. Ketelhuth   +9 more
doaj   +1 more source

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Journal for ImmunoTherapy of Cancer, 2023
Background Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan-dioxygenase (TDO) are enzymes catabolizing the essential amino acid tryptophan into kynurenine.
M. Solvay, Pauline Holfelder, Simon Klaessens, L. Pilotte, V. Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, R. Frédérick, E. de Plaen, C. Sers, C. Opitz, B. J. Van den Eynde, Jing-Jing Zhu   +13 more
semanticscholar   +1 more source

Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis

Gut microbes, 2022
Gut microbial disturbance affects allergic diseases including asthma, atopic dermatitis (AD) via the aberrant immune response. Some Bifidobacterial species and strains have been reported to improve AD via modulating immune-microbe interactions in ...
Zhifeng Fang, Tong Pan, Lingzhi Li, Hongchao Wang, Jinlin Zhu, Hao Zhang, Jianxin Zhao, Wei Chen, Wenwei Lu   +8 more
semanticscholar   +1 more source

Glycated Tryptophan in the Plasma of Chickens Fed Tryptophan-excess Diets

The Journal of Poultry Science, 2015
When tryptophan is glycated with glucose, it results in forming two types of glycated tryptophan, glucose-tryptophan Amadori product and (1R, 3S)-1-(D- gluco-1,2,3,4,5-pentahydroxypentyl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (PHP-THβC ...
Ryosuke Makino, Yoshimi Kawashima, Yuki Kajita, Toshiharu Namauo, Satoshi Ogawa, Hiroki Muraoka, Shinobu Fujimura, Kazumi Kita   +7 more
doaj   +1 more source

Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease

International Journal of Molecular Sciences, 2022
Actions of symbiotic gut microbiota are in dynamic balance with the host’s organism to maintain homeostasis. Many different factors have an impact on this relationship, including bacterial metabolites.
P. Konopelski, I. Mogilnicka
semanticscholar   +1 more source

Metformin reprograms tryptophan metabolism to stimulate CD8+ T cell function in colorectal cancer.

Cancer Research, 2023
Colorectal carcinogenesis coincides with immune cell dysfunction. Metformin has been reported to play a role in stimulating anti-tumor immunity, suggesting it could be used to overcome immunosuppression in colorectal cancer (CRC).
Xiaowen Huang, T. Sun, Jilin Wang, Xialu Hong, Huimin Chen, Tingting Yan, Chengbei Zhou, Danfeng Sun, Chen Yang, TaChung Yu, Wenyu Su, W. Du, H. Xiong   +12 more
semanticscholar   +1 more source

A comprehensive analysis of the importance of translation initiation factors for Haloferax volcanii applying deletion and conditional depletion mutants [PDF]

, 2013
Translation is an important step in gene expression. The initiation of translation is phylogenetically diverse, since currently five different initiation mechanisms are known.
Gäbel, Katrin, Näther, Daniela, Schmitt, Jessica, Schulz, Sebastian, Soppa, Jörg   +4 more
core   +7 more sources

Detection of Two Types of Glycated Tryptophan Compounds in the Plasma of Chickens Fed Tryptophan Excess Diets

The Journal of Poultry Science, 2013
When tryptophan is glycated with glucose, it results in forming two types of glycated tryptophan compounds, glucose-tryptophan Amadori product and (1R, 3S)-1-(D-gluco-1,2,3,4,5-pentahydroxypentyl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (PHP ...
Kazumi Kita, Yoshimi Kawashima, Ryosuke Makino, Toshiharu Namauo, Satoshi Ogawa, Hiroki Muraoka, Shinobu Fujimura   +6 more
doaj   +1 more source

Ginsenoside Rg1 Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Microbial Tryptophan Metabolism

Frontiers in Immunology, 2022
Ulcerative colitis (UC) is a chronic and recurrent inflammatory disorder in the gastrointestinal tract. Here, we examined the pharmacological effects of ginsenoside Rg1, a natural compound with low bioavailability, on the acute experimental colitis mice ...
Hao Cheng, Juan Liu, Dandan Zhang, Jing Wang, Yuzhu Tan, Yuzhu Tan, Wuwen Feng, Wuwen Feng, Cheng Peng, Cheng Peng   +9 more
doaj   +1 more source