Mutational analysis of the carbohydrate binding activity of the tobacco lectin [PDF]
, 2010 At present the three-dimensional structure of the tobacco lectin, further referred to as Nictaba, and its carbohydrate-binding site are unresolved. In this paper, we propose a three-dimensional model for the Nictaba domain based on the homology between ...
Barre, Annick +6 more
core +2 more sources
Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas
Nature Cancer, 2021 The dynamics and phenotypes of intratumoral myeloid cells during tumor progression are poorly understood. Here we define myeloid cellular states in gliomas by longitudinal single-cell profiling and demonstrate their strict control by the tumor genotype ...
M. Friedrich +37 more
semanticscholar +1 more source
Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain.
Advances in Nutrition, 2019 The gut-brain axis (GBA) is a bilateral communication network between the gastrointestinal (GI) tract and the central nervous system. The essential amino acid tryptophan contributes to the normal growth and health of both animals and humans and ...
K. Gao, C. Mu, A. Farzi, Weiyun Zhu
semanticscholar +1 more source
The role of human and microbial metabolites of triptophane in severe diseases and critical ill (review) [PDF]
Клиническая практика, 2020 The growing interest to metabolites circulating in the blood is associated with the accumulation of factual material on the involvement of low-molecular compounds in the development of a number of serious diseases.
M. L. Getsina +2 more
doaj +1 more source
Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects
International Journal of Tryptophan Research, 2017 Regulatory and functional aspects of the kynurenine (K) pathway (KP) of tryptophan (Trp) degradation are reviewed. The KP accounts for ~95% of dietary Trp degradation, of which 90% is attributed to the hepatic KP.
A. Badawy
semanticscholar +1 more source
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
Nature, 2022 Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme1–4.
Abhijeet Pataskar +23 more
semanticscholar +1 more source
Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle.
PLoS Biology, 2007 Mammalian cells rely on cellular uptake of the essential amino acid tryptophan. Tryptophan sequestration by up-regulation of the key enzyme for tryptophan degradation, indoleamine 2,3-dioxygenase (IDO), e.g., in cancer and inflammation, is thought to ...
Thijs Kaper +5 more
doaj +1 more source
Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism
Frontiers in Cellular and Infection Microbiology, 2018 The gut microbiota influences the health of the host, especially with regard to gut immune homeostasis and the intestinal immune response. In addition to serving as a nutrient enhancer, L-tryptophan (Trp) plays crucial roles in the balance between ...
Jing Gao +7 more
semanticscholar +1 more source
Tryptophan metabolism: Mechanism-oriented therapy for neurological and psychiatric disorders
Frontiers in Immunology, 2022 Neurological and psychiatric disorders are a category of chronic diseases that are widespread and pose serious mental and physical health problems for patients.
Dan Li +12 more
semanticscholar +1 more source
Animals, 2019 The objective of this study was to assess the impact of different dietary Trp concentrations on the stress and metabolism response of juvenile Senegalese soles (Solea senegalensis).
Marcelino Herrera +6 more
doaj +1 more source