Results 51 to 60 of about 436,973 (328)

Serotonin and Tryptophan Serum Concentrations in Shelter Dogs Showing Different Behavioural Responses to a Potentially Stressful Procedure

Veterinary Sciences, 2020
In mammals, serotonin (5-HT) levels depend on the availability of tryptophan (TRP). Low 5-HT concentrations have been linked to behavioural disorders in dogs.
Giacomo Riggio, Chiara Mariti, Valeria Sergi, Silvana Diverio, Angelo Gazzano   +4 more
doaj   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Dip2a regulates stress susceptibility in the basolateral amygdala

Neural Regeneration Research
Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters.
Jing Li, Zixuan He, Weitai Chai, Meng Tian, Huali Yu, Xiaoxiao He, Xiaojuan Zhu   +6 more
doaj   +1 more source

Distinct mechanisms of Drosophila CRYPTOCHROME-mediated light-evoked membrane depolarization and in vivo clock resetting. [PDF]

, 2019
Drosophila CRYPTOCHROME (dCRY) mediates electrophysiological depolarization and circadian clock resetting in response to blue or ultraviolet (UV) light.
Au, David D, Baik, Lisa S, Enrriquez-Villalva, Wendy K, Foden, Alexander J, Holmes, Todd C, Nave, Ceazar   +5 more
core   +1 more source

Tryptophan in Nutrition and Health

International Journal of Molecular Sciences, 2022
Tryptophan is a rate-limiting essential amino acid and a unique building block of peptides and proteins [...]
Poeggeler, Burkhard, Singh, Sandeep Kumar, Pappolla, Miguel A., Poeggeler, Burkhard; 1Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, Faculty of Biology and Psychology, Georg-August-University of Göttingen, Am Türmchen 3, 33332 Gütersloh, Germany, Singh, Sandeep Kumar; 2Indian Scientific Education and Technology Foundation, Lucknow 226002, India; sandeeps.bhu@gmail.com, Pappolla, Miguel A.; 3Department of Neurology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA; pappolla@aol.com   +5 more
openaire   +3 more sources

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Impact of Substance Use Disorder on Tryptophan Metabolism Through the Kynurenine Pathway: A Narrative Review

Metabolites
Background/Objectives: Substance use disorder is a crisis impacting many people in the United States. This review aimed to identify the effect addictive substances have on the kynurenine pathway.
Lindsey Contella, Christopher L. Farrell, Luigi Boccuto, Alain H. Litwin, Marion L. Snyder   +4 more
doaj   +1 more source

The relationship between Type D personality with atherosclerotic plaque and cardiovascular events: The mediation effect of inflammation and kynurenine/tryptophan metabolism

Frontiers in Cardiovascular Medicine, 2022
PurposeCardiovascular events and coronary plaque vulnerability are linked to Type D personality. However, the fundamental mechanism has not been clarified.
Yini Wang, Yini Wang, Guojie Liu, Zhenjuan Zhao, Ling Li, Shi Yin, Xiao Sun, Bo Yu, Xueqin Gao, Ping Lin, Yanjie Yang   +10 more
doaj   +1 more source

2014 REU Poster: Measuring Tryptophan Metabolism Using Analogs of Tryptophan [PDF]

, 2014
Poster presentation at REU Summer's End Research Symposium, 2014, by REU participant Thierno Diallo, Roxbury Community College - John "Chip" Celenza group, Sanda Zolj lab mentorNSF ...
Diallo, Thierno
core   +1 more source

An expanding range of targets for kynurenine metabolites of tryptophan [PDF]

, 2013
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail, Stone, Trevor W., Stoy, Nicholas   +2 more
core   +1 more source