Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target
Frontiers in Immunology, 2019 Inflammation aims to restore tissue homeostasis after injury or infection. Age-related decline of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype known as inflammaging that is involved in many age-related diseases ...
Freek J. H. Sorgdrager +4 more
semanticscholar +1 more source
Frontiers in Molecular Biosciences, 2018 Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a variety of secondary metabolites, a subset of which are involved in ...
Anutthaman Parthasarathy +6 more
doaj +1 more source
, 2006 Buchnera aphidicola, the primary endosymbiont of aphids, has undergone important genomic and biochemical changes as an adaptation to intracellular life.
Gil, Rosario +4 more
core +1 more source
Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline. [PDF]
, 2018 Cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are both effective treatments for some patients with obsessive-compulsive disorder (OCD), yet little is known about the neurochemical changes related to these ...
Barsoum, Amir +11 more
core +2 more sources
Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]
, 2010 Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
Berfelo, M. W. +6 more
core +2 more sources
Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis
Frontiers in Neuroscience, 2019 The link between gut microbiome and brain is being slowly acknowledged due to the speculated role of resident gut microbial community in altering the functions of gut-brain axis (GBA).
Harrisham Kaur, Chandra Bose, S. Mande
semanticscholar +1 more source
Inflammation-Induced Tryptophan Breakdown is Related With Anemia, Fatigue, and Depression in Cancer
Frontiers in Immunology, 2020 Many patients with cancer suffer from anemia, depression, and an impaired quality of life (QoL). These patients often also show decreased plasma tryptophan levels and increased kynurenine concentrations in parallel with elevated concentrations of Th1 ...
L. Lanser +6 more
semanticscholar +1 more source
From ab initio quantum mechanics to molecular neurobiology: A cation-pi binding site in the nicotinic receptor [PDF]
, 1998 The nicotinic acetylcholine receptor is the prototype ligand-gated ion channel. A number of aromatic amino acids have been identified as contributing to the agonist binding site, suggesting that cation-pi interactions may be involved in binding the ...
Dougherty, Dennis A. +5 more
core
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]
, 2009 Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Adams +37 more
core +2 more sources
Tryptophan metabolism in health and disease.
Cell Metabolism, 2023 Chen Xue +10 more
semanticscholar +1 more source