Results 11 to 20 of about 24,896 (176)

6-Nitrodopamine Potentiates Catecholamine-Induced Ca²⁺ _i Release in Human Aortic Smooth Muscle and Modulates Vascular Smooth Muscle Contractility. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Background In vascular smooth muscle, rises in intracellular calcium [Ca2+]i drive contraction downstream of α1‐adrenoceptor activation via IP3. Endothelium‐derived 6‐nitrodopamine (6‐ND) augments cardiac catecholamine actions; however, its effect on [Ca2+]i is unknown.
Britto-Júnior J, Lima AT, Qiao S, Tang HF, Cardenas V, Antunes E, De Nucci G, Ferro A.   +7 more
europepmc   +2 more sources

ttX calculations and modeling [PDF]

Proceedings of The Ninth Annual Conference on Large Hadron Collider Physics — PoS(LHCP2021), 2021
In this talk, we review the status of calculations for the associated production of a top pair and a Higgs, $W$ or $Z$ boson at the Large Hadron Collider. In particular, we focus on the resummation of soft gluon emission effects and on their combination with the complete set of next-to-leading-order corrections of both QCD and electroweak origin, in ...
Andrea Ferroglia, Alessandro Broggio, Rikkert Frederix, Davide Pagani, Benjamin D. Pecjak, Ioannis Tsinikos   +5 more
openaire   +1 more source

Alternative Pathways of Acetylcholine Release in the Colon: Role of High-Affinity Choline Transporters. [PDF]

Neurogastroenterol Motil
Mechanisms of Acetylcholine release, including typical and atypical release under neuronal blockade. Left panel illustrates the classical (quantal) cholinergic transmission and the right panel the mechanism described in the present study. High‐Affinity Choline Transporter (HCT), Acetylcholine (ACh), Acetylcholinesterase (ACE), and Tetrodotoxin (TTX ...
Martinez-Daunis A, Yordanova B, Traserra S, Vergara P, Jimenez M.   +4 more
europepmc   +2 more sources

The Excelsatoxin A-Receptor TMEM233 Modulates Nav1.8. [PDF]

FASEB J
TMEM233 is a largely uncharacterized transmembrane protein that enables the sensitivity of Nav1.8 to Excelasatoxin A, a naturally occurring peptide that can significantly reduce the fast inactivation of this ion channel (left) expressed in sensory neurons or different cell lines. Moreover, its presence enhances the use dependent block of Nav1.8 induced
Oprita G, Meyer MJA, Rudolf D, Pombeiro Stein ICA, Deuis JR, Tran HNT, Durek T, Tabea K, Sina J, Waxman SG, Dib-Hajj SD, Babes A, Vetter I, Leffler A.   +13 more
europepmc   +2 more sources

Transcriptome analysis revealed gene expression feminization of testis after exogenous tetrodotoxin administration in pufferfish Takifugu flavidus

BMC Genomics, 2022
Tetrodotoxin (TTX) is a deadly neurotoxin and usually accumulates in large amounts in the ovaries but is non-toxic or low toxic in the testis of pufferfish. The molecular mechanism underlying sexual dimorphism accumulation of TTX in ovary and testis, and
Xue He, Hexing Wu, Yaping Ye, Xiaolin Gong, Baolong Bao   +4 more
doaj   +1 more source

An almost nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an odorant for the grass puffer

Scientific Reports, 2022
Toxic puffers contain the potent neurotoxin, tetrodotoxin (TTX). Although TTX is considered to serve as a defense substance, previous behavioral studies have demonstrated that TTX acts as an attractive pheromone for some toxic puffers.
Yoshihisa Noguchi, Takehisa Suzuki, Keigo Matsutani, Ryo Sakakibara, Ryota Nakahigashi, Masaatsu Adachi, Toshio Nishikawa, Hideki Abe   +7 more
doaj   +1 more source

The Chemical and Evolutionary Ecology of Tetrodotoxin (TTX) Toxicity in Terrestrial Vertebrates

Marine Drugs, 2010
Tetrodotoxin (TTX) is widely distributed in marine taxa, however in terrestrial taxa it is limited to a single class of vertebrates (Amphibia). Tetrodotoxin present in the skin and eggs of TTX-bearing amphibians primarily serves as an antipredator ...
Charles T. Hanifin
doaj   +1 more source

Tetrodotoxin (TTX) as a Therapeutic Agent for Pain

Marine Drugs, 2012
Tetrodotoxin (TTX) is a potent neurotoxin that blocks voltage-gated sodium channels (VGSCs). VGSCs play a critical role in neuronal function under both physiological and pathological conditions.
Cruz Miguel Cendán, Cristina Sánchez-Fernández, Rafael González-Cano, Miguel Ángel Tejada, Enrique José Cobos, Francisco Rafael Nieto   +5 more
doaj   +1 more source

Response Surface Methodology for the Optimization of Ultrasound-Assisted Extraction of Tetrodotoxin from the Liver of Takifugu pseudommus

Toxins, 2018
Tetrodotoxin (TTX) is a marine biotoxin that has high scientific value. However, the lack of efficient TTX extraction and preparation methods has led to a scarcity of TTX samples for clinical application.
Xiaojun Zhang, Chengcheng Han, Si Chen, Le Li, Jingjing Zong, Junjie Zeng, Guangming Mei   +6 more
doaj   +1 more source

The skin microbiome facilitates adaptive tetrodotoxin production in poisonous newts

eLife, 2020
Rough-skinned newts (Taricha granulosa) use tetrodotoxin (TTX) to block voltage-gated sodium (Nav) channels as a chemical defense against predation.
Patric M Vaelli, Kevin R Theis, Janet E Williams, Lauren A O'Connell, James A Foster, Heather L Eisthen   +5 more
doaj   +1 more source