Results 81 to 90 of about 9,505,976 (163)

Macrophages as Potential Therapeutic Targets in Acute Myeloid Leukemia

Biomedicines
Acute myeloid leukemia (AML) is a heterogenous malignant hemopathy, and although new drugs have emerged recently, current treatment options still show limited efficacy.
Oana Mesaros, Madalina Onciul, Emilia Matei, Corina Joldes, Laura Jimbu, Alexandra Neaga, Oana Serban, Mihnea Zdrenghea, Ana Maria Nanut   +8 more
doaj   +1 more source

Engineering T cells to overcome the hostile tumour microenvironment [PDF]

, 2015
Adoptive immunotherapy with autologous T lymphocytes transduced with anti-tumour antigen-specific T cell receptors (TCRs) has emerged as a promising anti-cancer therapy.
Alvares, B
core  

Mitochondrial Regulation of Tumor-associated Macrophages

Shengwu huaxue yu shengwu wuli jinzhan
Tumor immune microenvironment is an important microecology for tumor development, where tumor-associated macrophages are the most abundant immune cells in the tumor immune microenvironment, with high plasticity and heterogeneity.
CAI Xiu-E, SU Shi-Cheng, LI Jiang
doaj   +1 more source

Reprogramming tumor-associated macrophages in gastric cancer: a pathway to enhanced immunotherapy

Frontiers in Immunology
Gastric cancer (GC) remains a significant global health concern due to its poor prognosis and limited therapeutic options, particularly in advanced stages.
Yibo He, Qianran Hong, Shiliang Chen, Jiayi Zhou, Shengliang Qiu   +4 more
doaj   +1 more source

Comprehensive scRNA-seq analysis to identify new markers of M2 macrophages for predicting the prognosis of prostate cancer

Annals of Medicine
Background Prostate cancer (PCa) has become the highest incidence of malignant tumor among men in the world. Tumor microenvironment (TME) is necessary for tumor growth. M2 macrophages play an important role in many solid tumors.
Yitian Ou, Chengxing Xia, Chunwei Ye, Mingming Liu, Haiyang Jiang, Yong Zhu, Delin Yang   +6 more
doaj   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science
Background Building upon our previous finding that tumor‐derived lactate activates DESMIN+ cancer‐associated fibroblasts (CAFs) to secrete interleukin‐8 (IL‐8), this study investigates the downstream IL‐8/C‐X‐C motif chemokine receptor 2 (CXCR2) axis in ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
doaj   +1 more source

Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]

, 2013
Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
core  

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science
Polybromo 1 (PBRM1) ranks as the second most commonly mutated gene in clear cell renal cell carcinoma (ccRCC), while its role in immune escape remains elusive.
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
doaj   +1 more source

Tumor-associated macrophages contribute to tumor hypoxia and glycolysis

, 2017
1
Bok, Seoyeon, AHN, G ONE, 김영은, BUMJOO, HONG, HOI, BIN JEONG   +4 more
core  

The Role Of Tumor-Associated Macrophages In Human Skin Cancer [PDF]

, 2013
Inflammation has long been associated with tumorigenesis. Macrophages are cells of the innate immune system, whose density within tumors correlates with a worsening clinical prognosis in most types of tumors.
Cyrus, Nika
core