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Tumor-Associated Macrophages: Protumoral Macrophages in Inflammatory Tumor Microenvironment [PDF]

Advanced Pharmaceutical Bulletin, 2020
Tumor microenvironment consists of malignant and non-malignant cells. The interaction of these dynamic and different cells is responsible for tumor progression at different levels.
Somaiyeh Malekghasemi, Jafar Majidi, Amir Baghbanzadeh, Jalal Abdolalizadeh, Behzad Baradaran, Leili Aghebati-Maleki   +5 more
doaj   +3 more sources

Tumor-Associated Macrophages in Tumor Immunity [PDF]

Frontiers in Immunology, 2020
Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two functionally contrasting subtypes, namely classical activated M1 macrophages and alternatively activated ...
Yueyun Pan, Yueyun Pan, Yinda Yu, Xiaojian Wang, Ting Zhang, Ting Zhang   +5 more
doaj   +3 more sources

Progress in targeting tumor-associated macrophages in cancer immunotherapy [PDF]

Guangxi Yike Daxue xuebao
As the member of immune cells, macrophages are necessary to fight against pathogenic invasion and activate T cell-mediated adaptive immune responses.
ZHANG Siyu, ZHOU Qiong
doaj   +2 more sources

Morphological heterogeneity of intratumoral macrophages in prostate tumors

Сибирский онкологический журнал, 2023
Background. Prostate cancer (PCa) is the most common human cancer worldwide. In the progression of prostate cancer, the total number of macrophages in the tumor tissue is associated with poor prognosis and increased risk of metastasis.
K. V. Danilko, K. I. Enikeeva, I. R. Kabirov, S. Y. Maksimova, D. S. Vishnyakov, J. G. Kzhyshkowska, V. N. Pavlov   +6 more
doaj   +1 more source

Tumor-Associated Macrophages: A Potential Target for Cancer Therapy

Frontiers in Oncology, 2021
Macrophages, an important class of innate immune cells that maintain body homeostasis and ward off foreign pathogens, exhibit a high degree of plasticity and play a supportive role in different tissues and organs.
Yifan Tan, Min Wang, Yang Zhang, Shengyang Ge, Fan Zhong, Guowei Xia, Chuanyu Sun   +6 more
doaj   +1 more source

The role of macrophages-mediated communications among cell compositions of tumor microenvironment in cancer progression

Frontiers in Immunology, 2023
Recent studies have revealed that tumor-associated macrophages are the most abundant stromal cells in the tumor microenvironment and play an important role in tumor initiation and progression.
Mengyuan Li, Ping Jiang, Shuhua Wei, Junjie Wang, Chunxiao Li   +4 more
doaj   +1 more source

Tumor-Associated Macrophages: Critical Players in Drug Resistance of Breast Cancer

Frontiers in Immunology, 2021
Drug resistance is one of the most critical challenges in breast cancer (BC) treatment. The occurrence and development of drug resistance are closely related to the tumor immune microenvironment (TIME).
Maoyu Xiao, Jun He, Liyang Yin, Xiguan Chen, Xuyu Zu, Yingying Shen   +5 more
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Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy

Frontiers in Oncology, 2020
Osteosarcoma is a malignant primary bone tumor commonly occurring in children and adolescents. The treatment of local osteosarcoma is mainly based on surgical resection and chemotherapy, whereas the improvement of overall survival remains stagnant ...
Zhong-Wei Luo, Zhong-Wei Luo, Pan-Pan Liu, Zhen-Xing Wang, Zhen-Xing Wang, Chun-Yuan Chen, Chun-Yuan Chen, Hui Xie, Hui Xie, Hui Xie, Hui Xie, Hui Xie, Hui Xie   +12 more
doaj   +1 more source

Tumor-Associated Neutrophils and Macrophages—Heterogenous but Not Chaotic

Frontiers in Immunology, 2020
Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) have been extensively studied. Their pleotropic roles were observed in multiple steps of tumor progression and metastasis, and sometimes appeared to be inconsistent across ...
Ling Wu, Ling Wu, Ling Wu, Xiang H.-F. Zhang, Xiang H.-F. Zhang, Xiang H.-F. Zhang, Xiang H.-F. Zhang   +6 more
doaj   +1 more source

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]

, 2011
Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2).
AB Al-Mehdi, AD Borowsky, AJ Minn, AM Havens, B Brandt, B Qian, Bin-Zhi Qian, BS Nielsen, DR Getts, DR Rhodes, Elizabeth A. Kaiser, F Geissmann, F Geissmann, F Geissmann, FK Swirski, H Saji, HP Gerber, Hui Zhang, Jeffrey W. Pollard, JH Im, Jinghang Zhang, Jiufeng Li, JM Carton, Liam R. Campion, Linda A. Snyder, MD Abramoff, P Stern, P Tsui, RT Palframan, T Ueno, T Valkovic, Takanori Kitamura, Y Huang   +32 more
core   +2 more sources