Ontogeny of Tumor-Associated Macrophages [PDF]
Frontiers in Immunology, 2019 Tumor-associated macrophages (TAM) represent the main immune cell population of the tumor microenvironment in most cancer. For decades, TAM have been the focus of intense investigation to understand how they modulate the tumor microenvironment and their ...
Marie Laviron, Alexandre Boissonnas
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Immunotherapy Targeting Tumor-Associated Macrophages [PDF]
Frontiers in Medicine, 2020 Macrophages are phagocytic cells that play a broad role in maintaining body homeostasis and defense against foreign pathogens; whereas tumor-associated macrophages (TAMs) support tumor growth and metastasis by promoting cancer cell proliferation and ...
Yafei Liu, Rongsi Wang
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Targeting Tumor-Associated Macrophages for Imaging
Pharmaceutics, 2022 As an important component of the tumor immune microenvironment (TIME), tumor-associated macrophages (TAMs) occupy a significant niche in tumor margin aggregation and respond to changes in the TIME.
Jiahao Hu, Xiaoling Xu, Yongzhong Du
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Tumor Associated Macrophages in Kidney Cancer [PDF]
Analytical Cellular Pathology, 2016 Tumor associated macrophages (TAMs) are an important element of tumor stroma. They originate from blood monocytes attracted by chemokines and cytokines produced by tumor cells and, being instructed by tumor microenvironment, develop into potent tumor ...
Olga V. Kovaleva +3 more
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Tumor-associated macrophages [PDF]
Current Biology, 2020 Cassetta and Pollard introduce tumor-associated macrophages and discuss their origin, diversity, function and plasticity.
Cassetta, Luca, Pollard, Jeffrey
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Tumor‐associated macrophages in immunotherapy [PDF]
The FEBS Journal, 2021 Tumor‐associated macrophages (TAMs) are essential components of the tumor microenvironment involved in the progression and metastasis of cancer. They are intimately involved in angiogenesis and immunosuppression in normal and malignant tissues, as well as pro‐fibrotic activities.
Shijia Yan, Guohui Wan
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Tumor-associated macrophages in osteosarcoma
Journal of Zhejiang University-SCIENCE B, 2021 Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. It is an aggressive tumor with a tendency to spread to the lung, which is the most common site of metastasis. Patients with advanced OS with metastases have poor prognoses despite the application of chemotherapy, thus highlighting the need for novel therapeutic targets.
Yi Zhao +4 more
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Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L [PDF]
, 2014 Solid tumors are infiltrated by immune cells where macrophages and senescent T cells are highly represented. Within the tumor microenvironment, a cross-talk between the infiltrating cells may occur conditioning the characteristic of the in situ immune ...
Acosta Rodriguez, Eva Virginia +8 more
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Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]
, 2019 Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong +14 more
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Tissue Microenvironments Define and Get Reinforced by Macrophage Phenotypes in Homeostasis or during Inflammation, Repair and Fibrosis [PDF]
, 2012 Current macrophage phenotype classifications are based on distinct in vitro culture conditions that do not adequately mirror complex tissue environments.
Weidenbusch, Marc, Anders, Hans-Joachim
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