Results 21 to 30 of about 612,424 (282)

Identification and manipulation of tumor associated macrophages in human cancers [PDF]

, 2011
Evading immune destruction and tumor promoting inflammation are important hallmarks in the development of cancer. Macrophages are present in most human tumors and are often associated with bad prognosis.
A Algars, A Corthay, A Mantovani, A Mantovani, A Mantovani, A Puig-Kroger, A Rigo, A Takahashi, A Terlou, A Tzankov, AM Figel, B Caillou, BM Burt, BZ Qian, C Bailey, C Lonnroth, C Murdoch, C Porta, C Steidl, C van Kooten, CH Lee, CJ Melief, CM Ohri, CM Ohri, D Azambuja, D Duluc, D Hanahan, D Kabelitz, D Nagorsen, D Niino, D Pilling, D Wang, DG DeNardo, DG DeNardo, DI Gabrilovich, DM Kuang, DM Kuang, DM Mosser, E Choy, E Schmitt, E Zeni, EM Verdegaal, ES Jordanova, F Avila-Moreno, F Pages, F Porcheray, FA Verreck, FO Martinez, FO Martinez, GL Beatty, H Dalwadi, H Hasita, H Kurahara, H Roca, H Takayama, H Van Gorp, H Yu, HJ Zijlmans, I Espinosa, I Kryczek, I Kryczek, I Shabo, IH Bronkhorst, J Chen, J Coward, J Forssell, J Gadiot, J Ma, J Pander, J Zhang, JA Webster, JC Kang, JR Brown, JS Pettersen, K Kawamura, K Movahedi, L Apetoh, L Bingle, L Sanchez-Martin, LS Hammes, M Herfs, M Heusinkveld, M Ryder, M van Dongen, MB Maniecki, MD Martin, MH McLean, MJ Campbell, MJ Edelman, MJ Welters, MM Tiemessen, Moniek Heusinkveld, N Nonomura, N Obermajer, NN Hunder, PJ de Vos van Steenwijk, PJ Murray, R Bos, R Karim, RB Mailliard, RD Stout, RD Stout, RM Steinman, RS Freedman, S Banerjee, S Gordon, S Osinsky, S Wirths, SJ Piersma, Sjoerd H van der Burg, SK Biswas, T Krausgruber, T Kreider, T Lawrence, TJ Curiel, TO Jensen, W Xu, X Yang, Y Komohara, Y Nakanishi, YS Shieh   +120 more
core   +3 more sources

Notch Signaling in Macrophages in the Context of Cancer Immunity

Frontiers in Immunology, 2018
Macrophages play both tumor-suppressing and tumor-promoting roles depending on the microenvironment. Tumor-associated macrophages (TAMs) are often associated with poor prognosis in most, but not all cancer.
Tanapat Palaga, Tanapat Palaga, Wipawee Wongchana, Wipawee Wongchana, Patipark Kueanjinda, Patipark Kueanjinda   +5 more
doaj   +1 more source

Tumor-Associated Macrophages Affect the Tumor Microenvironment and Radioresistance via the Upregulation of CXCL6/CXCR2 in Hepatocellular Carcinoma

Biomedicines, 2023
Background: Hepatocellular carcinoma is the sixth most diagnosed malignancy and the fourth most common cause of cancer-related mortality globally. Despite progress in the treatment of liver cancer, nonsurgical treatments remain unsatisfactory, and only ...
Hsin-Lun Lee, Yi-Chieh Tsai, Narpati Wesa Pikatan, Chi-Tai Yeh, Vijesh Kumar Yadav, Ming-Yao Chen, Jo-Ting Tsai   +6 more
doaj   +1 more source

Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. [PDF]

, 2017
Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects.
Albert Lo, Andrey Loboda, Ashani T. Weeraratna, Ayumi Hashimoto, Brian Nam, Butowski, Carus, Challacombe, Chao, Charles Mulligan, Chunsheng Zhang, Condamine, Conway, Coussens, David W. Speicher, DeNardo, Dmitry I. Gabrilovich, Douglas Marvel, Ellen Puré, Fang Wang, Fearon, Feig, Finke, Fred Denstman, Gabrilovich, Gabrilovich, Gascard, Genovese, Gentles, Greenberg, Grivennikov, Guleria, Huang, Kato, Kumar, Ladanyi, Laxminarasimha Donthireddy, Lin, Linda A. Snyder, Lo, Lokeshwar, Lucas, Lucia R. Languino, MacDonald, Manuel A. Sepulveda, Mao, Marlee A. Goins, Messmer, Meyer, Mishra, Mitchem, Mok, Mok, Neil Hockstein, Newman, Noman, Obermajer, Ohno, Orimo, Peter Ordentlich, Pixley, Prashanthi Vonteddu, Pyonteck, Qin Liu, Ramachandran, Reeti Behera, Ries, Ries, Robert H. Vonderheide, Sasse, Sergio Lavilla-Alonso, Shanti Shakamuri, Sionov, Sluijter, Solito, Strachan, Szkandera, Talmadge, Tap, Thomas Condamine, Timothy Chao, Vetsika, Vinit Kumar, Wang, Weber, Xiaowei Xu, Xu, Yang, Zhang, Zhang, Zhu   +90 more
core   +2 more sources

A unidirectional transition from migratory to perivascular macrophage is required for tumor cell intravasation [PDF]

, 2018
Summary: Tumor-associated macrophages (TAMs) are critical for tumor metastasis. Two TAM subsets support cancer cell intravasation: migratory macrophages guide cancer cells toward blood vessels, where sessile perivascular macrophages assist their entry ...
Arwert, Esther, Condeelis, John S, Entenberg, David, Harney, Allison, Pollard, Jeffrey, Sahai, Erik, Wang, Yarong   +6 more
core   +2 more sources

Influencing Factors and Significance of Tumor-associated Macrophage Polarization 
in Tumor Microenvironment

Chinese Journal of Lung Cancer, 2023
Tumor-associated macrophages (TAMs), characterized by high plasticity, are the most abundant immune cells in the tumor microenvironment (TME). TAMs are recruited to tumor region in response to various TME components such as cytokines, chemokines as well ...
Wenke GE, Weibing WU
doaj   +1 more source

Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages [PDF]

, 2007
Genetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)‐induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy.
Barleon, Cho, de Felipe, Dong, Donnelly, Dvorak, Elaine Y. Lin, Eubank, Ferrara, Ferrara, Folkman, Gabriel Bricard, Giraudo, Gouon-Evans, Grunewald, Gunther, Guy, Hanahan, Jain, Jeffrey W. Pollard, Jiu-feng Li, Keyt, Kumaraswamy, Leek, Leek, Leek, Leung, Lewis, Lin, Lin, Lin, Lin, Lobov, Mok, Naumov, Pollard, Rani Sellers, Ross, Sasmono, Schoeffner, Scholl, Shima, Steven A. Porcelli, Sunderkotter, Varney, Weigang Wang, Yan Deng, Yoshida   +47 more
core   +1 more source

Metabolic reprograming of tumor-associated macrophages [PDF]

Annals of Translational Medicine, 2020
A large body of scientific evidence corroborated by clinical and animal model experiments indicates that tumor-associated macrophages (TAMs) play a crucial role in tumor development and progression. TAMs are a key immune cell type present in tumor microenvironment (TME) and associated with poor prognosis, drug resistance, enhanced angiogenesis and ...
Puthenveetil, Abhishek, Dubey, Shweta
openaire   +2 more sources

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]

, 2018
Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D, Chavez, Michael, Davis, Ryan R, Ferrara, Katherine W, Fite, Brett Z, Hubbard, Neil E, Ilovitsh, Asaf, Ingham, Elizabeth S, Mahakian, Lisa M, Monjazeb, Arta M, Murphy, William J, Silvestrini, Matthew T, Tam, Sarah M, Tepper, Clifford G   +13 more
core   +1 more source

CD169+ Macrophages Residing in the Draining Lymph Nodes and Infiltrating the Tumor Play Opposite Roles in the Pathogenesis of Bladder Cancer

Research and Reports in Urology, 2023
Masakazu Nagata,1 Kazuhiro Ishizaka,1 Touko Asano1,2 1Department of Urology, Teikyo University Hospital Mizonokuchi, Kawasaki, Kanagawa, Japan; 2Department of Urology, Omori Red Cross Hospital, Ota, Tokyo, JapanCorrespondence: Touko Asano, Department of ...
Nagata M, Ishizaka K, Asano T
doaj