Results 41 to 50 of about 612,424 (282)

Dysregulation of macrophage polarization is associated with the metastatic process in osteosarcoma [PDF]

, 2016
Osteosarcoma (OS) is the most common bone sarcoma in adolescents, and has poor prognosis. A vicious cycle is established between OS cells and their microenvironment in order to facilitate the tumor growth and cell spreading.
Baldini, Blanchard, Celton-Jansen, Chou, Cleton-Jansen, Dalton, Edwards, Fan, Feistritzer, Fidler, Getty, Griffioen, Hass, Heymann, Heymann, Heymann, Heymann, Heymann, Heymann, Heymann, Heymann, Heymann, Hogendoorn, Holen, Hughes, Joyce, Lewis, Martinez, Meyers, Napoli, Napoli, Paget, Pollard, Pollard, Pollard, Pollard, Redini, Rodriguez, Rosen, Rédini, Saunders, Saunders, Schiffman, Schilham, Schwitter, The ESMO / European Sarcoma Network Working Group, Trichet, Wang, Wiedermann, Yang   +49 more
core   +9 more sources

Progress of research on the relationship between efferocytosis and tumor

Frontiers in Oncology
Tumors are genetic changes that develop in an organism as a result of many internal and external causes. They affect the biological behavior of cells, cause them to grow independently, and give rise to new, perpetually proliferating organisms.
Xuexin Yao, Ling Zhang, Siyi Sun, Aishuang Fu, Yanlei Ge   +4 more
doaj   +1 more source

Next frontier in tumor immunotherapy: macrophage-mediated immune evasion

Biomarker Research, 2021
Tumor-associated macrophages (TAMs), at the core of immunosuppressive cells and cytokines networks, play a crucial role in tumor immune evasion. Increasing evidences suggest that potential mechanisms of macrophage-mediated tumor immune escape imply ...
Yingqi Qiu, Tong Chen, Rong Hu, Ruiyi Zhu, Chujun Li, Yingchen Ruan, Xiaoling Xie, Yuhua Li   +7 more
doaj   +1 more source

Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models [PDF]

, 2017
Purpose: Glioblastoma multiforme (GBM) is the most aggressive brain tumor. The activity of vosaroxin, a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, was investigated in GBM preclinical models as a ...
Colapietro, Alessandro, Di Cesare, Ernesto, Festuccia, Claudio, Fox, Judith A., Gravina, Giovanni Luca, Mancini, Andrea, Marampon, Francesco, Mattei, Claudia, Rossi, Giulia, Ventura, Luca, Vetuschi, Antonella, Vitale, Flora   +11 more
core   +1 more source

Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies

Experimental Hematology & Oncology, 2021
Macrophages are heterogeneous cells that present as different functional phenotypes due to their plasticity. They can be classified into two categories, namely M1- and M2-like macrophages, which are involved in processes as diverse as anti-tumor activity
Shangli Zhu, Ming Yi, Yuze Wu, Bing Dong, Kongming Wu   +4 more
doaj   +1 more source

Tissue-Resident and Recruited Macrophages in Primary Tumor and Metastatic Microenvironments: Potential Targets in Cancer Therapy

Cells, 2021
Macrophages within solid tumors and metastatic sites are heterogenous populations with different developmental origins and substantially contribute to tumor progression.
Tiziana Cotechini, Aline Atallah, Arielle Grossman   +2 more
doaj   +1 more source

Targeting tumor-associated macrophages to synergize tumor immunotherapy

Signal Transduction and Targeted Therapy, 2021
The current treatment strategies in advanced malignancies remain limited. Notably, immunotherapies have raised hope for a successful control of these advanced diseases, but their therapeutic responses are suboptimal and vary considerably among ...
Xiaonan Xiang, Jianguo Wang, Di Lu, Xiao Xu   +3 more
doaj   +1 more source

Pathologic evaluation of tumor-associated macrophage density and vessel inflammation in invasive breast carcinomas [PDF]

, 2017
Tumor-associated macrophages (TAMs) are major constituents of the tumor microenvironment in solid tumors and have been implicated as mediators of tumor progression, invasion and metastasis.
Adhikari, Smita, Chervoneva, Inna, Hasan, Nafis, Leslie, Macall, Morita, Yoshihiro, Rui, Hallgeir, Tanaka, Takemi, Zhang, Roy   +7 more
core   +2 more sources

Exosomal MicroRNAs Mediating Crosstalk Between Cancer Cells With Cancer-Associated Fibroblasts and Tumor-Associated Macrophages in the Tumor Microenvironment

Frontiers in Oncology, 2021
Exosomes are small extracellular vesicles containing diverse bioactive molecules. They play essential roles in mediating bidirectional interplay between cancer and stromal cells. Specific elements are selected into different types of exosomes via various
Tong Su, Panpan Zhang, Fujun Zhao, Shu Zhang   +3 more
doaj   +1 more source

Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]

, 2019
Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C, Duan, Zhenfeng, Feng, Wenlong, Hornicek, Francis J, Shi, Huirong   +4 more
core   +2 more sources