Bioengineered models to study tumor dormancy [PDF]
Journal of Biological Engineering, 2019 The onset of cancer metastasis is the defining event in cancer progression when the disease is considered lethal. The ability of metastatic cancer cells to stay dormant for extended time periods and reawaken at later stages leading to disease recurrence ...
Shreyas S. Rao +2 more
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The Relationship Between Mesenchymal Stem Cells and Tumor Dormancy [PDF]
Frontiers in Cell and Developmental Biology, 2021 Tumor dormancy, a state of tumor, is clinically undetectable and the outgrowth of dormant tumor cells into overt metastases is responsible for cancer-associated deaths.
Linxian Zhao +6 more
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Remodeling the tumor dormancy ecosystem to prevent recurrence and metastasis [PDF]
Signal Transduction and Targeted TherapyDormant tumor cells, major contributors to tumor recurrence and metastasis, are characterized by cell cycle arrest and reactivation potential. Tumor dormancy arises from the dynamic interplay between intrinsic tumor properties and extrinsic factors ...
Yu Liang +3 more
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Tumor Dormancy and Reactivation: The Role of Heat Shock Proteins [PDF]
CellsTumors are a heterogeneous group of cell masses originating in various organs or tissues. The cellular composition of the tumor cell mass interacts in an intricate manner, influenced by humoral, genetic, molecular, and tumor microenvironment cues that ...
Haneef Ahmed Amissah +2 more
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Sleepyhead, deadly awakening: the dynamics of metastatic organotropism, tumor dormancy and therapeutic implications [PDF]
Frontiers in OncologyAs per the global mortality-related data, metastasis and tumor-related relapse are the major determinants of cancer-related deaths. This phenomenon is largely driven by tumor dormancy - a state in which disseminated tumor cells (DTCs) persist in a non ...
Soumyajit Sarkar, Suresh P. K.
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Tumor dormancy and relapse: understanding the molecular mechanisms of cancer recurrence [PDF]
Military Medical ResearchCancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have the ability to evade detection and treatment, leading to relapse.
Muhammad Tufail, Can-Hua Jiang, Ning Li
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Advances in the molecular regulation mechanism of tumor dormancy and its therapeutic strategy [PDF]
Discover OncologyTumor dormancy is a stage in the growth and development of malignant cells and is one of the biological characteristics of malignant cells. Complex transitions involving dormant tumor cells between quiescent and proliferative states pose challenges for ...
Yuan Wang +7 more
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Local and distant tumor dormancy during early stage breast cancer are associated with the predominance of infiltrating T effector subsets [PDF]
Breast Cancer Research, 2020 Background Although breast cancer mortality is a result of distant recurrences associated with the establishment of tumor dormancy, current clinical practice guidelines recommend a wait and watch approach for tumor recurrences.
Hussein F. Aqbi +13 more
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Engineered In Vitro Models of Tumor Dormancy and Reactivation [PDF]
Journal of Biological Engineering, 2018 Metastatic recurrence is a major hurdle to overcome for successful control of cancer-associated death. Residual tumor cells in the primary site, or disseminated tumor cells in secondary sites, can lie in a dormant state for long time periods, years to ...
Shantanu Pradhan +3 more
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Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy [PDF]
Cells, 2020 Here, we provide an overview of the importance of cellular fate in cancer as a group of diseases of abnormal cell growth. Tumor development and progression is a highly dynamic process, with several phases of evolution.
Francisco Triana-Martínez +2 more
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