Results 11 to 20 of about 26,025 (289)
Molecular Oncology, 2017 Metastasis is the primary cause of death in cancer patients and current treatments fail to provide durable responses. Efforts to treat metastatic disease are hindered by the fact that metastatic cells often remain dormant for prolonged intervals of years,
Aceto +119 more
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Tumor dormancy and disease recurrence. [PDF]
Cancer Metastasis Rev, 2023 Kirkland JL.
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Tumor Dormancy: Biologic and Therapeutic Implications. [PDF]
World J Oncol, 2022 Metastatic cancer can arise years after treatment of the primary tumor because residual tumor cells can enter dormancy and evade elimination by anti-neoplastic therapies. The mechanisms underlying this phenomenon have been investigated and a number of hypotheses have been proposed.
Balayan V, Guddati AK.
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Cancer Rep (Hoboken), 2020 AbstractBackgroundBone marrow is a common site of metastasis for a number of tumor types, including breast, prostate, and lung cancer, but the mechanisms controlling tumor dormancy in bone are poorly understood. In breast cancer, while advances in drug development, screening practices, and surgical techniques have dramatically improved survival rates ...
Mayhew V, Omokehinde T, Johnson RW.
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Tumor Dormancy: Implications for Invasion and Metastasis. [PDF]
Int J Mol Sci, 2021 Tumor dormancy refers to a critical stage of cancer development when tumor cells are present, but cancer does not progress. It includes both the concept of cellular dormancy, indicating the reversible switch of a cancer cell to a quiescent state, and that of tumor mass dormancy, indicating the presence of neoplastic masses that have reached cell ...
Gomatou G +3 more
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Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma
Journal of Experimental & Clinical Cancer Research, 2021 Background Patients were prone to have poor prognosis once dormant tumor cells being reactivated. However, the molecular mechanism of tumor cell dormancy remains poorly understood.
Xiao Yang +10 more
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Pan-Cancer Survey of Tumor Mass Dormancy and Underlying Mutational Processes
Frontiers in Cell and Developmental Biology, 2021 Tumor mass dormancy is the key intermediate step between immune surveillance and cancer progression, yet due to its transitory nature it has been difficult to capture and characterize. Little is understood of its prevalence across cancer types and of the
Anna Julia Wiecek +4 more
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Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer. [PDF]
PLoS ONE, 2012 Breast cancers can recur after removal of the primary tumor and treatment to eliminate remaining tumor cells. Recurrence may occur after long periods of time during which there are no clinical symptoms.
Ryung S Kim +6 more
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Journal of Experimental & Clinical Cancer Research, 2023 Background Disseminated tumor cells (DTCs) can enter a dormant state and cause no symptoms in cancer patients. On the other hand, the dormant DTCs can reactivate and cause metastases progression and lethal relapses.
Ruihua Liu +10 more
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A cellular automaton model for tumor dormancy: emergence of a proliferative switch. [PDF]
PLoS ONE, 2014 Malignant cancers that lead to fatal outcomes for patients may remain dormant for very long periods of time. Although individual mechanisms such as cellular dormancy, angiogenic dormancy and immunosurveillance have been proposed, a comprehensive ...
Duyu Chen, Yang Jiao, Salvatore Torquato
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